Date published: 2026-6-6

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Sox-2 Inhibitors

Sox-2 inhibitors belong to a significant class of compounds in the realm of molecular biology and drug development. These inhibitors are specifically designed to target and modulate the activity of the transcription factor Sox-2, which is a crucial component of cellular processes. Transcription factors are proteins that play a pivotal role in regulating gene expression, controlling the synthesis of RNA from DNA. Sox-2, short for SRY (sex-determining region Y)-box 2, is part of the Sox family of transcription factors, which are known to be involved in embryonic development, cell fate determination, and maintenance of pluripotency in stem cells.

The intricate structure of Sox-2 inhibitors is designed to interact with the Sox-2 protein, ultimately influencing its binding to DNA and subsequent gene expression. The aim of these inhibitors is to modulate the function of Sox-2, which is intricately tied to various biological processes. Researchers have focused on developing potent Sox-2 inhibitors to gain a deeper understanding of the complex molecular mechanisms that regulate cellular differentiation, development, and the maintenance of cellular identity. The implications of these inhibitors extend beyond basic research, as they have the ability to shed light on the intricate network of molecular events that shape the destiny of cells, offering insights into avenues for further exploration and discovery.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$151.00
4
(1)

BIX-01294 inhibits SOX-2 expression by targeting the lysine methyltransferase G9a and inducing epigenetic modifications.

Salinomycin

53003-10-4sc-253530
sc-253530C
sc-253530A
sc-253530B
5 mg
10 mg
25 mg
100 mg
$162.00
$241.00
$406.00
$474.00
1
(1)

Salinomycin reduces SOX-2 levels by inhibiting Wnt/β-catenin signaling and inducing autophagy-mediated degradation.

Piperlongumine

20069-09-4sc-364128
10 mg
$107.00
(1)

Piperlongumine inhibits SOX-2 expression by disrupting redox signaling pathways and inducing reactive oxygen species (ROS) production.

Withaferin A

5119-48-2sc-200381
sc-200381A
sc-200381B
sc-200381C
1 mg
10 mg
100 mg
1 g
$130.00
$583.00
$4172.00
$20506.00
20
(1)

Withaferin A targets SOX-2 by inhibiting Hsp90 and disrupting the protein's stability, leading to its degradation.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG suppresses SOX-2 expression through its anti-inflammatory properties and by inhibiting the PI3K/AKT/mTOR pathway.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid inhibits SOX-2 expression by binding to retinoic acid receptors and promoting their interaction with co-repressors.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Sulforaphane downregulates SOX-2 by activating the Nrf2/ARE pathway and inhibiting NF-κB-mediated transcription.

Niclosamide

50-65-7sc-250564
sc-250564A
sc-250564B
sc-250564C
sc-250564D
sc-250564E
100 mg
1 g
10 g
100 g
1 kg
5 kg
$38.00
$79.00
$188.00
$520.00
$1248.00
$5930.00
8
(1)

Niclosamide inhibits SOX-2 expression by interfering with Wnt/β-catenin signaling and promoting proteasomal degradation.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin inhibits SOX-2 expression by suppressing NF-κB signaling and disrupting the PI3K/AKT pathway.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol downregulates SOX-2 by activating the AMPK pathway and inhibiting Wnt/β-catenin signaling.