Sox-2 inhibitors belong to a significant class of compounds in the realm of molecular biology and drug development. These inhibitors are specifically designed to target and modulate the activity of the transcription factor Sox-2, which is a crucial component of cellular processes. Transcription factors are proteins that play a pivotal role in regulating gene expression, controlling the synthesis of RNA from DNA. Sox-2, short for SRY (sex-determining region Y)-box 2, is part of the Sox family of transcription factors, which are known to be involved in embryonic development, cell fate determination, and maintenance of pluripotency in stem cells.
The intricate structure of Sox-2 inhibitors is designed to interact with the Sox-2 protein, ultimately influencing its binding to DNA and subsequent gene expression. The aim of these inhibitors is to modulate the function of Sox-2, which is intricately tied to various biological processes. Researchers have focused on developing potent Sox-2 inhibitors to gain a deeper understanding of the complex molecular mechanisms that regulate cellular differentiation, development, and the maintenance of cellular identity. The implications of these inhibitors extend beyond basic research, as they have the ability to shed light on the intricate network of molecular events that shape the destiny of cells, offering insights into avenues for further exploration and discovery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 inhibits SOX-2 expression by targeting the lysine methyltransferase G9a and inducing epigenetic modifications. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin reduces SOX-2 levels by inhibiting Wnt/β-catenin signaling and inducing autophagy-mediated degradation. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine inhibits SOX-2 expression by disrupting redox signaling pathways and inducing reactive oxygen species (ROS) production. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A targets SOX-2 by inhibiting Hsp90 and disrupting the protein's stability, leading to its degradation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG suppresses SOX-2 expression through its anti-inflammatory properties and by inhibiting the PI3K/AKT/mTOR pathway. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid inhibits SOX-2 expression by binding to retinoic acid receptors and promoting their interaction with co-repressors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane downregulates SOX-2 by activating the Nrf2/ARE pathway and inhibiting NF-κB-mediated transcription. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide inhibits SOX-2 expression by interfering with Wnt/β-catenin signaling and promoting proteasomal degradation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits SOX-2 expression by suppressing NF-κB signaling and disrupting the PI3K/AKT pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol downregulates SOX-2 by activating the AMPK pathway and inhibiting Wnt/β-catenin signaling. | ||||||