Niclosamide Niclosamide is an inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor.

Niclosamide (CAS 50-65-7)

Niclosamide | CAS 50-65-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 2′,5-Dichloro-4′-nitrosalicylanilide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Application: Niclosamide is an inhibitor of the Stat3 signaling pathway and also a FRAP inhibitor
CAS Number: 50-65-7
Molecular Weight: 327.12
Molecular Formula: C13H8Cl2N2O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.


References

1. Balgi, Aruna D., et al., 2009. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PloS one. 4(9): e7124. PMID: 19771169

2. Jin, Yanli., et al., 2010. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer research. 70(6): 2516-27. PMID: 20215516

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
225-233° C
Boiling Point :
~424.5° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
STAT3: IC50 = 0.25 µM; Wnt3a from stimulating HEK293 cellular LEF/TCF transcription activity: IC50 = 0.5 µM; DU-145: IC50 = 0.7 µM (human); Dishevelled-2 downregulation: IC50 = ~1 µM; Flg: IC50 = 13.1 µM (human)
pK Values :
pKa: 7.45 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
VN8400000
PubChem CID :
Merck Index :
14: 6519
MDL Number :
MFCD00057597
EC Number :
200-056-8
Beilstein Registry :
2820605
SMILES :
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

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Certificate of Analysis

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Niclosamide (CAS 50-65-7)  Product Citations

See how others have used Niclosamide (CAS 50-65-7). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31451218  Biochem. Biophys. Res. Commun. 518: 638-643.

PMID: # 25465182  Vet Microbiol. 438-447.

PMID: # 30500562  Metab. Clin. Exp. 43-52.

PMID: # 25746684  Vet Microbiol. 370-7.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Jin et al Jin et al. (PubMed ID 20215516) found that niclosamide inhibited DNA binding of NF-kappaB and increased reactive oxygen species in acute myelogenous leukemia cells. -SCBT Publication Review
Date published: 2015-01-25
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