SNM1B Activators
SNM1B activators belong to a distinctive chemical class that plays a pivotal role in modulating cellular processes associated with DNA repair and maintenance. SNM1B, also known as Apollo, is a DNA exonuclease with endonuclease activity, primarily localized in the nucleus. The activators of SNM1B are characterized by their ability to enhance the enzymatic functions of SNM1B, thereby contributing to the efficient resolution of various DNA lesions.
These small molecules interact with specific binding sites on SNM1B, inducing conformational changes that augment its catalytic activity. As a consequence, SNM1B activators participate in the intricate network of cellular mechanisms that ensure genomic stability. SNM1B involve intricate interactions between the activators and the enzyme's catalytic domains. Structural studies have revealed that these activators often bind to key residues within the active site of SNM1B, facilitating a more effective engagement with DNA substrates. This enhanced interaction promotes the precise recognition and processing of damaged DNA, supporting the overall fidelity of DNA repair pathways. Importantly, the activation of SNM1B by these compounds appears to be finely tuned, reflecting the intricate regulatory mechanisms governing DNA repair processes. Further research into the specific structural and biochemical properties of SNM1B activators holds promise for advancing our understanding of cellular DNA repair mechanisms and may have implications for the development of novel strategies to modulate DNA repair pathways for various biological applications.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is a potent ribonucleotide reductase inhibitor, inducing DNA replication stress and subsequently activating SNM1B as part of the repair response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts that distort the DNA helix and require repair, engaging SNM1B for DNA interstrand crosslink repair. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor causing an accumulation of single-strand breaks that can progress to double-strand breaks repaired by SNM1B. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor, causing DNA damage that necessitates the involvement of SNM1B. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II poison leading to double-strand breaks and activation of SNM1B. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
3′-Azido-3′-deoxythymidine incorporates into growing DNA strands and induces DNA damage, calling for SNM1B's repair activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that can cause an imbalance in nucleotide pools, leading to DNA damage and subsequent SNM1B activation. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA double-strand breaks, which require SNM1B for repair. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil incorporates into DNA and RNA, leading to damage that necessitates SNM1B involvement. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA causing double-strand breaks that activate SNM1B. | ||||||