3prime-Azido-3prime-deoxythymidine CAS: 30516-87-1
MF: C10H13N5O4
MW: 267.3
An inhibitor of HIV-1 reverse transcriptase.

3′-Azido-3′-deoxythymidine (CAS 30516-87-1)

3′-Azido-3′-deoxythymidine | CAS 30516-87-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Azidothymidine; Retrovir; Zidovudinum
Application: 3′-Azido-3′-deoxythymidine is an inhibitor of HIV-1 reverse transcriptase
CAS Number: 30516-87-1
Purity: ≥99%
Molecular Weight: 267.3
Molecular Formula: C10H13N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

3′-Azido-3′-deoxythymidine is an inhibitor of HIV-1 RT (HIV-1 reverse transcriptase) that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3′-Azido-3′-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.


References

Gomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107. Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223. Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211. Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53. Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115. R: 23/24/25; S: 36-45

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
113-115° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XP2072000
PubChem CID :
35370
Merck Index :
14: 10123
MDL Number :
MFCD00006536
Beilstein Registry :
3595791
SMILES :
CC1=CN(C(=O)NC1=O)[[email protected]]2C[[email protected]@H]([[email protected]](O2)CO)N=[N+]=[N-]

Download SDS (MSDS)

Certificate of Analysis

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3prime-Azido-3prime-deoxythymidine (CAS 30516-87-1)  Product Citations

See how others have used 3prime-Azido-3prime-deoxythymidine (CAS 30516-87-1). Click on the entry to view the PubMed entry .

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PMID: # 24487230  Thein, P. et al. 2014. Hear. Res. 310: 27-35.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Onwuamah Onwuamah, CK. et al. (PubMed 25233270) reported foetal loss and enhanced fertility in mice treated with 3 -Azido-3 -deoxythymidine. -SCBT Publication Review
Date published: 2015-07-05
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