SNF2L Inhibitors
SNF2L inhibitors are chemical entities that can diminish the functional activity of SNF2L, a protein involved in chromatin remodeling and DNA repair. These inhibitors primarily include DNA-binding antineoplastic antibiotics and inhibitors of histone deacetylases (HDACs) and DNA methyltransferase. By inhibiting these specific cellular processes and signaling molecules, the inhibitors can influence SNF2L's function without directly blocking its activity.
Mithramycin A, an antineoplastic antibiotic, can inhibit the transcription of a variety of genes. Given that SNF2Lparticipates in chromatin remodeling, the disruption of gene transcription by Mithramycin A can lead to a decrease in SNF2L activity. Similarly, Trichostatin A, a potent inhibitor of class I and II HDACs, can disrupt the chromatin remodeling processes that SNF2L is involved in, leading to its decreased activity. The nucleoside analogue 5-Azacytidine incorporates into DNA and RNA and inhibits DNA methyltransferase, contributing to hypomethylation. SNF2L's role in DNA methylation and chromatin remodeling can be affected by this inhibition, leading to a decrease in its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A is a DNA-binding antineoplastic antibiotic that can inhibit the transcription of a variety of genes. SNF2L is involved in DNA repair and chromatin remodeling. By inhibiting gene transcription, Mithramycin A can disrupt the normal functioning of SNF2L, potentially leading to its decreased functional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent and specific inhibitor of class I and II histone deacetylases (HDACs), which are involved in chromatin remodeling. By inhibiting HDACs, Trichostatin A can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analogue that incorporates into DNA and RNA and inhibits DNA methyltransferase, leading to hypomethylation. SNF2L is involved in DNA methylation and chromatin remodeling. By inhibiting DNA methylation, 5-Azacytidine can disrupt the normal functioning of SNF2L, potentially leading to its decreased functional activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase (HDAC) inhibitor. SNF2L is a part of chromatin remodeling complexes and by inhibiting HDACs, Vorinostat can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a potent and selective histone deacetylase (HDAC) inhibitor. By inhibiting HDACs, Romidepsin can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is a potent histone deacetylase inhibitor. By inhibiting histone deacetylases, Belinostat can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent pan-deacetylase inhibitor. By inhibiting deacetylases, Panobinostat can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is a potent class I histone deacetylase inhibitor. By inhibiting histone deacetylases, Entinostat can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
SB939 | 929016-96-6 | sc-364610 sc-364610A | 5 mg 50 mg | $205.00 $834.00 | ||
SB939 is a potent histone deacetylase inhibitor. By inhibiting histone deacetylases, Pracinostat can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
Tacedinaline is a synthetic benzamide and histone deacetylase inhibitor. By inhibiting histone deacetylases, Tacedinaline can disrupt chromatin remodeling processes that SNF2L is involved in, potentially leading to its decreased functional activity. | ||||||