Molecular structure of SB939, CAS Number: 929016-96-6
SB939 (CAS 929016-96-6)
Alternate Names:
Pracinostat
Application:
SB939 is a non-selective inhibitor of HDAC
CAS Number:
929016-96-6
Molecular Weight:
358.48
Molecular Formula:
C20H30N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
SB939 is a potent inhibitor of HDAC class I and II isoenzymes, HDAC1, HDAC2, HDAC3 HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 and HDAC10 with the IC50 values ranging from 43 nM to 140 nM. HDAC6 shows an IC50 of 1008 nM. It markedly inhibits HDAC11 of the HDAC class IV enzymes with an IC50 of 93 nM. SB939 shows significant anti-proliferative activity against a wide variety of tumor cell lines, especially Leukemia cells and cutaneous T-cell Lymphoma cells with IC50 values ranging from 50 nM (H9 cells) to 170 nM (HEL92.1.7 cells).
Inhibitor of:
ANKRD20A5, HDA1, HDA4, HDAC, MAGE-B1, MAGE-F1, Mammaglobin A, pan-Acetyl, PHF12, Ribosomal Protein S6, SNF2L, and TTC1.Activator of:
2900008C10Rik, and ATF-7IP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB939, 5 mg | sc-364610 | 5 mg | $209.00 | |||
SB939, 50 mg | sc-364610A | 50 mg | $851.00 |