Date published: 2026-1-7

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Mithramycin A (CAS 18378-89-7)

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Alternate Names:
Aureolic acid;Plicamycin
Application:
Mithramycin A is a polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA
CAS Number:
18378-89-7
Purity:
>96%
Molecular Weight:
1085.15
Molecular Formula:
C52H76O24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Mithramycin A is a compound extensively researched for its ability to bind DNA and influence gene expression. It is particularly known for its specific binding to G-C rich regions of DNA, which allows researchers to study the transcriptional regulation of genes with such sequences. Studies involving mithramycin A focus on its role in inhibiting the transcription factor Sp1, which is in the regulation of various genes involved in cell cycle control and differentiation. This has made mithramycin A useful in the field of molecular biology, where it is used to dissect the mechanisms of gene regulation. Moreover, the compound is utilized to understand the cellular response to changes in gene expression patterns, especially in the context of cellular proliferation and viability. Mithramycin A′s ability to modulate chromatin structure is also of interest as it provides a means to investigate the dynamic nature of the epigenetic landscape.


Mithramycin A (CAS 18378-89-7) References

  1. Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3.  |  Mir, MA., et al. 2003. Bioorg Med Chem. 11: 2791-801. PMID: 12788353
  2. Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression.  |  Ahn, SY., et al. 2004. Am J Pathol. 164: 1663-72. PMID: 15111313
  3. Mithramycin A activates Fas death pathway in leukemic cell lines.  |  Leroy, I., et al. 2006. Apoptosis. 11: 113-9. PMID: 16374547
  4. Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.  |  Mansilla, S., et al. 2010. Biochem Pharmacol. 79: 1418-27. PMID: 20093108
  5. Topical mithramycin-A modulates submucosal collagen deposition after esophageal burn injury in rats.  |  Davis, PL., et al. 2011. Otolaryngol Head Neck Surg. 145: 435-41. PMID: 21521900
  6. The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.  |  Zavala, K., et al. 2014. Neurosci Lett. 578: 211-6. PMID: 24468003
  7. Mithramycin blocks protein binding and function of the SV40 early promoter.  |  Ray, R., et al. 1989. J Clin Invest. 83: 2003-7. PMID: 2542379
  8. Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease.  |  Wei, C., et al. 2016. Neurochem Res. 41: 1924-38. PMID: 27072684
  9. Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach.  |  Ragheb, R., et al. 2017. Arch Dermatol Res. 309: 611-623. PMID: 28695331
  10. Mithramycin A Improves Functional Recovery by Inhibiting BSCB Disruption and Hemorrhage after Spinal Cord Injury.  |  Lee, JY., et al. 2018. J Neurotrauma. 35: 508-520. PMID: 29048243
  11. Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage.  |  Scroggins, BT., et al. 2018. Int J Radiat Oncol Biol Phys. 100: 344-352. PMID: 29157749
  12. Increased heterologous production of the antitumoral polyketide mithramycin A by engineered Streptomyces lividans TK24 strains.  |  Novakova, R., et al. 2018. Appl Microbiol Biotechnol. 102: 857-869. PMID: 29196786
  13. Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1.  |  Liu, R., et al. 2018. Sci Rep. 8: 1138. PMID: 29348684
  14. Mithramycin A Alleviates Osteoarthritic Cartilage Destruction by Inhibiting HIF-2α Expression.  |  Choi, MC. and Choi, WH. 2018. Int J Mol Sci. 19: PMID: 29747385
  15. Mithramycin A Inhibits Colorectal Cancer Growth by Targeting Cancer Stem Cells.  |  Quarni, W., et al. 2019. Sci Rep. 9: 15202. PMID: 31645574
  16. Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma.  |  Federico, A., et al. 2020. Mol Ther Oncolytics. 18: 83-99. PMID: 32637583
  17. Specific protein 1 inhibitor mithramycin A protects cardiomyocytes from myocardial infarction via interacting with PARP.  |  Geng, H., et al. 2021. In Vitro Cell Dev Biol Anim. 57: 315-323. PMID: 33580416
  18. Combination Therapy of Mithramycin A and Immune Checkpoint Inhibitor for the Treatment of Colorectal Cancer in an Orthotopic Murine Model.  |  Dutta, R., et al. 2021. Front Immunol. 12: 706133. PMID: 34381456
  19. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms.  |  Fawad, JA., et al. 2022. Gastroenterology. 163: 1377-1390.e11. PMID: 35934064

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Mithramycin A, 1 mg

sc-200909
1 mg
$55.00