SNAI 1 Inhibitors
SNAI1 inhibitors represent a category of chemical compounds that modulate the activity of the SNAI1 gene product, also known as SNAIL1. SNAIL1 is a zinc finger transcription factor that plays a pivotal role in the cellular process known as epithelial-to-mesenchymal transition (EMT). This process is fundamental to the development of many tissues and organs during embryogenesis. However, it can be reactivated under pathological conditions, such as in fibrosis and cancer progression. The activity of SNAIL1 can be modulated by various signaling pathways, including Wnt/β-catenin, TGF-β, and the NF-κB pathway. Therefore, many SNAI1 inhibitors function by interfering with these upstream signaling pathways that regulate the expression or activity of SNAIL1.
The chemical structures of SNAI1 inhibitors vary widely, and these compounds do not comprise a single, well-defined class of molecules. Instead, the category includes a diverse array of substances, including both synthetic and naturally occurring compounds. For instance, small molecules like salinomycin, a polyether antibiotic, inhibit SNAIL1 by selectively killing cancer stem cells and interfering with Wnt/β-catenin signaling. Many natural compounds, such as curcumin, resveratrol, and epigallocatechin gallate (EGCG), have been shown to downregulate SNAIL1 expression, often by inhibiting NF-κB or TGF-β signaling. Furthermore, several flavonoids, including quercetin and kaempferol, can also decrease SNAIL1 expression, likely by inhibiting the PI3K/AKT or Wnt/β-catenin pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin selectively kills cancer stem cells by inhibiting Wnt/β-catenin signaling, which indirectly downregulates SNAIL1, leading to the suppression of EMT. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide inhibits the Wnt/β-catenin pathway, leading to the downregulation of SNAIL1. This results in a reduction in EMT and inhibition of cancer cell migration and invasion. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural compound, inhibits SNAIL1 by suppressing the nuclear factor-kappa B (NF-κB) signaling pathway. This results in decreased EMT, cancer cell migration, and invasion. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol inhibits SNAIL1 by suppressing the TGF-β signaling pathway, leading to reduced EMT, cancer cell migration, and invasion. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin, a natural anthraquinone derivative, downregulates SNAIL1 by inhibiting the PI3K/AKT signaling pathway, thereby suppressing EMT, cell migration, and invasion. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol, a natural compound, inhibits SNAIL1 by suppressing the STAT3 signaling pathway, leading to decreased EMT, cell migration, and invasion. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine downregulates SNAIL1 by inhibiting the ERK signaling pathway, resulting in suppression of EMT, cancer cell migration, and invasion. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, decreases SNAIL1 expression by inhibiting the PI3K/AKT pathway, leading to reduced EMT, cancer cell migration, and invasion. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, inhibits SNAIL1 by downregulating the NF-κB signaling pathway, resulting in suppression of EMT, cancer cell migration, and invasion. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane inhibits SNAIL1 by downregulating the NF-κB signaling pathway, leading to reduced EMT, cancer cell migration, and invasion. | ||||||