SMC6 Activators
SMC6 activators primarily function by influencing the energy and phosphorylation status of the protein or its interacting partners. ATP is a crucial energy source that facilitates the DNA repair and maintenance functions of the SMC6 protein, which is a component of the ATPase SMC5/6 complex. The availability of ATP enhances the functional activity of the SMC6 protein. Similarly, adenosine can be phosphorylated to ATP within the cell, providing the necessary energy for SMC6's functions. Sodium Orthovanadate and Okadaic Acid are inhibitors of protein phosphatases. They can potentially enhance SMC6 activity by maintaining the phosphorylation status of its interacting proteins.
SMC6 activators also enhance the functional activity of the protein by modulating the phosphorylation status of the protein and its interactome. Forskolin, a known activator of adenylate cyclase, increases intracellular cAMP levels, leading to protein phosphorylation that can potentially influence SMC6 activity. Dibutyryl-cAMP, a membrane-permeable analog of cAMP, activates protein kinase A (PKA), which can phosphorylate various proteins, potentially affecting SMC6 function. IBMX, a non-specific inhibitor of phosphodiesterases, also enhances cAMP levels, indirectly leading to protein phosphorylation that may affect SMC6 function. Additionally, compounds like Epigallocatechin Gallate (EGCG), Curcumin, Resveratrol, Quercetin, and Genistein can modulate various cellular pathways, potentially affecting the DNA repair and maintenance pathways where SMC6 is involved. EGCG and Curcumin are known to interact with a broad spectrum of proteins and could enhance SMC6 function by affecting its interacting network. Resveratrol and Quercetin, known to modulate several signaling pathways, could potentially influence the functional activity of SMC6. Genistein, a tyrosine kinase inhibitor, can potentially affect the phosphorylation status of SMC6 or its interacting proteins, thereby modulating SMC6 function. Thus, the SMC6 activators work through a variety of mechanisms, primarily involving the modulation of energy availability and phosphorylation status, to enhance the functional activity of the SMC6 protein.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP is a key source of energy for cellular processes. SMC6 is a component of the SMC5/6 complex, which is an ATPase. The binding and hydrolysis of ATP by the SMC5/6 complex is essential for its function in DNA repair and maintenance. ATP availability enhances the functional activity of SMC6 by providing the necessary energy for its function. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine is a purine nucleoside that can be phosphorylated to ATP inside the cell. The increased availability of ATP enhances the functional activity of SMC6 by providing the energy required for its function in DNA repair and maintenance. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a potent inhibitor of protein tyrosine phosphatases. Given that SMC6 might interact with proteins that undergo phosphorylation, this agent can potentially enhance the activity of SMC6 by maintaining the phosphorylation status of its interacting proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it may maintain the phosphorylation status of SMC6 or its interacting proteins, thereby enhancing the functional activity of SMC6. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to an increase in intracellular cAMP levels, which can indirectly lead to the phosphorylation of proteins. This can potentially enhance the functional activity of SMC6 by affecting its phosphorylation status or that of its interacting proteins. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a membrane-permeable analog of cAMP and can activate protein kinase A (PKA) inside the cell. PKA can phosphorylate a multitude of proteins, potentially affecting the functional activity of SMC6. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels. This can potentially lead to phosphorylation of proteins affecting SMC6's function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to interact with and modulate various proteins. Given that SMC6 works in a complex network of interactions, EGCG might enhance SMC6 function by affecting its interaction network. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has multiple targets and can influence various cellular pathways, potentially affecting the DNA repair and maintenance pathways where SMC6 is involved. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to modulate several signaling pathways, potentially affecting the pathways where SMC6 is involved. | ||||||