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Sodium Orthovanadate (CAS 13721-39-6)

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Alternate Names:
Sodium Orthovanadate is also known as Vanadate.
Application:
Sodium Orthovanadate is a potent inhibitor of several alkaline phosphatases and tyrosine phosphates with an IC50 of 10 µM.
CAS Number:
13721-39-6
Purity:
≥99%
Molecular Weight:
183.91
Molecular Formula:
Na3O4V
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium Orthovanadate is a used general inhibitor for protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP) and ATPase. Sodium Orthovanadate acts as a competitive inhibitor and is completely reversible upon the addition of EDTA or by dilution. The PTP activities of Sodium Orthovanadate are conveniently separable from the protein phosphoseryl and phosphothreonyl phosphatase (PSP) activities inhibited by Fluoride and EDTA. Sodium Orthovanadate is routinely used to preserve the protein tyrosyl phosphorylation state in cells, cell lysates, and protein tyrosine kinase assays.


Sodium Orthovanadate (CAS 13721-39-6) References

  1. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor.  |  Gordon, JA. 1991. Methods Enzymol. 201: 477-82. PMID: 1943774
  2. Sodium orthovanadate inhibits p53-mediated apoptosis.  |  Morita, A., et al. 2010. Cancer Res. 70: 257-65. PMID: 20048077
  3. Sodium orthovanadate induces the apoptosis of SH-SY5Y cells by inhibiting PIWIL2.  |  Tian, X., et al. 2016. Mol Med Rep. 13: 874-80. PMID: 26647781
  4. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway.  |  Liu, J., et al. 2016. Apoptosis. 21: 546-57. PMID: 26921179
  5. Sodium Orthovanadate Inhibits Proliferation and Triggers Apoptosis in Oral Squamous Cell Carcinoma in vitro.  |  Khalil, AA. and Jameson, MJ. 2017. Biochemistry (Mosc). 82: 149-155. PMID: 28320298
  6. Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways.  |  Jiang, W., et al. 2018. Sci Rep. 8: 9706. PMID: 29946188
  7. Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages.  |  Korbecki, J., et al. 2020. Biol Trace Elem Res. 193: 152-161. PMID: 30927246
  8. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology.  |  Akhtar, A., et al. 2020. Brain Res Bull. 164: 83-97. PMID: 32784004
  9. Sodium orthovanadate inhibits growth of acute leukemia HL60 cells and HL60/A cells in vitro.  |  Zhang, L., et al. 2020. Biosci Rep. 40: PMID: 32940655
  10. Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice.  |  Nishiyama, Y., et al. 2021. Int J Radiat Biol. 97: 1241-1251. PMID: 34125648
  11. Antidepressant-like effect of sodium orthovanadate in a mouse model of chronic unpredictable mild stress.  |  Joshi, A., et al. 2022. Eur J Pharmacol. 919: 174798. PMID: 35123977
  12. p38-dependent c-Jun degradation contributes to reduced PGE2 production in sodium orthovanadate-treated macrophages.  |  Aziz, N., et al. 2022. BMB Rep. 55: 389-394. PMID: 35410635
  13. Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells.  |  Kim, HG., et al. 2022. Toxicol Rep. 9: 1883-1893. PMID: 36518371
  14. Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate.  |  Huyer, G., et al. 1997. J Biol Chem. 272: 843-51. PMID: 8995372

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium Orthovanadate, 5 g

sc-3540
5 g
$45.00

Sodium Orthovanadate, 10 g

sc-3540B
10 g
$56.00

Sodium Orthovanadate, 50 g

sc-3540A
50 g
$183.00

Avez vous un protocol pour l utilisation de l inhibiteur sur des preparations de tissus homogenes? Merci

Asked by: Farid
Merci pour votre question. Nous n'avons pas de protocole recommandé pour cette utilisation particulière. Thank you for your question. We do not have a recommended protocol for this particular use.
Answered by: Tech Support Europe
Date published: 2023-07-12

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Sodium Orthovanadate, sc-3540, is a white to off-white solid.
Answered by: Chemical Support 4
Date published: 2017-04-21
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Rated 4 out of 5 by from Chemical worked well in our experimentsChemical worked well in our experiments, happy with purchase.
Date published: 2015-06-01
Rated 4 out of 5 by from Sodium Orthovanadate is shown to inhibitSodium Orthovanadate is shown to inhibit the action of lambda protein phosphatase, thus no change in protein expression p-Cofilin 1 in K-562 cells is observed, when compared to untreated cells. It is a known phosphatase inhibitor for protein tyrosine phosphatases. -SCBT QC
Date published: 2015-05-19
Rated 4 out of 5 by from Worked adequatelyWorked adequately.
Date published: 2015-04-08
Rated 4 out of 5 by from Working well in the labWorking well in the lab.
Date published: 2015-03-19
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Sodium Orthovanadate is rated 4.0 out of 5 by 4.
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