Adenosine 5prime-Triphosphate, disodium salt CAS: 987-65-5
MF: C10H14N5O13P3•2Na
MW: 551.14
A p2 purinergicagonist.

Adenosine 5′-Triphosphate, disodium salt (CAS 987-65-5)

Adenosine 5′-Triphosphate, disodium salt | CAS 987-65-5 is rated 5.0 out of 5 by 1.
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Alternate Names: ATP disodium salt
Application: Adenosine 5′-Triphosphate, disodium salt is a p2 purinergicagonist
CAS Number: 987-65-5
Purity: ≥98%
Molecular Weight: 551.14
Molecular Formula: C10H14N5O13P32Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Adenosine 5'-Triphosphate, disodium salt is a p2 purinergic (P2X and P2Y) agonist that increases Ca2+-activated K+ channel activity. It has been found to induce a release of prostoglandin D2 and histamine from rat peritoneal mast cells in a dose-dependent manner.


References

1. Gordon, J.L. 1986. Biochem. J. 233: 309-319. PMID: 3006665
2. Guibert, C., et al. 1998. Br. J. Pharmacol. 123: 1732-1740. PMID: 9605582
3. Burnstock, G. 2006. Trends Pharmacol. Sci. 27: 166-176. PMID: 16487603

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (110 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), DMF (sparingly), and PBS pH 7.2 (~10 mg/ml).
Storage :
Store at -20° C
Melting Point :
188-190° C
Refractive Index :
n20D 1.90 (Predicted)
Optical Activity :
α20/D -19°, c = 3 in water
IC50 :
Purinergic receptor P2Y1: EC5050 = 2 nM (rat); P2X1: EC5050 = 56 nM (human); MAPKAPK-2: IC50 = 2.8 µM (human); HSP 70: IC50 = 3.37 µM (human); HSC 70: IC50 = 17.3 µM (human)
Ki Data :
P2Y4: Ki= 630.96 nM (human); Adenylate kinase 2: Ki= 90 µM (rat); GK1: Ki= 200 µM (human); Adenylate kinase 1: Ki= 570 µM (rat); Ketopantoate reductase: Ki= 610 µM (Escherichia coli K-12)
pK Values :
pKa: 4.0 (amino group), 6.5(secondary phosphate)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
AU7417000
PubChem CID :
Merck Index :
14: 155
MDL Number :
MFCD00080339
EC Number :
213-579-1
Beilstein Registry :
3585462
SMILES :
C1=NC2=C(C(=N1)N)N=CN2[[email protected]]3[[email protected]@H]([[email protected]@H]([[email protected]](O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O.[Na+].[Na+]

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Certificate of Analysis

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Adenosine 5prime-Triphosphate, disodium salt (CAS 987-65-5)  Product Citations

See how others have used Adenosine 5prime-Triphosphate, disodium salt (CAS 987-65-5). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 18813227  Cheng, A. et al. 2009. Cell Res. 19: 187-195.

PMID: # 19446543  Pouokam, E. et al. 2009. Eur. J. Pharmacol. 615: 40-49.

PMID: # 17892520  Oishi, Y. et al. 2008. Acta Physiol (Oxf). 192: 381-395.

PMID: # 16380182  Akudugu, JM. et al. 2006. Radiother Oncol. 78: 17-26.

PMID: # 16462736  Zheng, J. et al. 2006. Nat. Neurosci. 9: 363-371.

PMID: # 15118397  Strbenc, M. et al. 2004. Cells Tissues Organs (Print). 176: 178-186.

PMID: # 14631145  Beskid, S. et al. 2003. Cell. Physiol. Biochem. 13: 385-390.

PMID: # 11417220  Vennekens, R. et al. 2001. Pflugers Arch. 442: 237-242.

PMID: # 2886366  Kurose, H. et al. 1987. FEBS Lett. 219: 375-379.

Citations 1 to 9 of 9 total
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Rated 5 out of 5 by from Guibert et al Guibert et al. (PubMed ID 9605582) found that Adenosine 5'-Triphosphate, disodium salt and other P2-recepetor agonists potentiate ectonucleotidase and have a relaxant effect in rat portal vein smooth muscle. -SCBT Publication Review
Date published: 2015-05-25
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