SH3GL2 Inhibitors
SH3GL2 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of the SH3GL2 protein, also known as Endophilin A1. SH3GL2 is a vital component in the process of clathrin-mediated endocytosis, playing a significant role in synaptic vesicle recycling and membrane curvature formation. The protein contains an SH3 (Src Homology 3) domain and a BAR (Bin/Amphiphysin/Rvs) domain, which facilitate its interactions with other proteins and lipids, respectively. By binding to the SH3 domain, these inhibitors prevent SH3GL2 from interacting with its protein partners, such as dynamin and synaptojanin, thereby disrupting the assembly of the endocytic machinery. Alternatively, inhibitors may target the BAR domain to interfere with the protein's ability to induce membrane curvature, which is essential for vesicle formation.
The development of SH3GL2 inhibitors involves understanding the structural and functional aspects of the protein to design molecules that can effectively bind to its active sites. These inhibitors are valuable tools in biochemical research for elucidating the role of SH3GL2 in cellular processes like endocytosis, membrane trafficking, and synaptic function. By modulating the activity of SH3GL2, researchers can study the downstream effects on neuronal communication, signal transduction, and cellular homeostasis. The characterization of these inhibitors typically involves assays to determine their binding affinity, specificity, and impact on SH3GL2-mediated pathways. Through such studies, SH3GL2 inhibitors contribute to a deeper understanding of the molecular mechanisms governing membrane dynamics and protein-protein interactions in cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin causes DNA damage by intercalating between DNA bases and inhibiting topoisomerase II, triggering a cascade that can lead to the downregulation of SH3GL2 as cells attempt to mitigate damage. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may decrease the expression of SH3GL2 by binding to retinoic acid receptors, which can alter the transcription of genes directly involved in endocytic processes. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate impedes nucleotide synthesis by inhibiting dihydrofolate reductase, which could lead to a decrease in the transcriptional capacity for genes like SH3GL2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, through inhibition of histone deacetylase, causes increased acetylation of histones, which can repress transcription of certain genes, potentially including SH3GL2. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen binds to estrogen receptors and can alter the transcription of genes responsive to estrogen signaling, which may result in the downregulation of SH3GL2 in some tissues. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may activate the Nrf2 pathway, leading to changes in gene expression that could include the downregulation of SH3GL2 as part of a broader stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may suppress the expression of SH3GL2 by inhibiting NF-kB pathway activation, which is involved in the transcriptional control of many genes, including those related to endocytosis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuin pathways, which could decrease expression of SH3GL2 through alterations in chromatin structure and subsequent transcriptional repression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can inhibit the phosphorylation of certain kinases involved in signal transduction, which may lead to reduced expression of SH3GL2 due to lowered transcriptional activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms crosslinks within DNA, which may halt the cell cycle and lead to decreased SH3GL2 expression as part of a response to genotoxic stress. | ||||||