SENP2 Activators
SENP2 activators represent a diverse group of chemicals that modulate the activity of SENP2 through various pathways and cellular processes. MLN4924, a NEDD8-activating enzyme (NAE) inhibitor, indirectly activates SENP2 by preventing the neddylation of proteins. This inhibition alters post-translational modifications, including changes in SUMOylation, creating conditions favorable for SENP2 activation. Nutlin-3, a p53 stabilizer, indirectly activates SENP2 by stabilizing p53 and promoting its interaction with SENP2, modulating the p53 pathway and influencing SENP2-dependent deSUMOylation events. C646, a histone acetyltransferase p300/CBP inhibitor, indirectly activates SENP2 by inhibiting p300/CBP-mediated acetylation events, creating conditions conducive to SENP2-dependent deacetylation. Pargyline, an MAO-B inhibitor, indirectly activates SENP2 by inhibiting MAO-B activity, modulating the sumoylation status of proteins associated with the MAO-B pathway. JIB-04, a histone demethylase inhibitor, indirectly activates SENP2 by inhibiting histone demethylases, creating conditions conducive to SENP2-dependent deSUMOylation events.
RSL3, a ferroptosis inducer, indirectly activates SENP2 by inhibiting GPX4, influencing the desumoylation and stabilization of proteins involved in ferroptosis. Niclosamide, influencing Wnt/β-catenin signaling, leads to alterations in the sumoylation status of proteins associated with Wnt/β-catenin signaling, activating SENP2. BAY 11-7082, an NF-κB inhibitor, indirectly activates SENP2 by inhibiting NF-κB activation, modulating the sumoylation status of proteins associated with the NF-κB pathway. Sirtinol, a sirtuin inhibitor, indirectly activates SENP2 by inhibiting SIRT1, modulating the sumoylation status of proteins regulated by SIRT1. Cyclopamine, a Hedgehog signaling pathway inhibitor, indirectly activates SENP2 by inhibiting Hedgehog signaling, modulating the sumoylation status of proteins associated with this pathway. These SENP2 activators showcase the intricate network of cellular processes and signaling pathways through which SENP2 function can be modulated, providing insights into the complex regulation of post-translational modifications and protein stability in diverse cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a small molecule inhibitor of NEDD8-activating enzyme (NAE), preventing the neddylation of proteins. SENP2, a SUMO-specific protease, is known to be regulated by neddylation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 is an inhibitor of the interaction between p53 and MDM2, leading to p53 stabilization and activation. SENP2 has been reported to interact with and stabilize p53 by desumoylating it. Nutlin-3 indirectly activates SENP2 by stabilizing p53 and promoting its interaction with SENP2. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective inhibitor of the histone acetyltransferase p300/CBP. SENP2 is known to regulate the acetylation status of proteins. C646 indirectly activates SENP2 by inhibiting p300/CBP-mediated acetylation events, creating conditions conducive to SENP2-dependent deacetylation. | ||||||
Pargyline hydrochloride | 306-07-0 | sc-215676 sc-215676A | 500 mg 1 g | $39.00 $82.00 | 2 | |
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO). SENP2 has been implicated in the regulation of monoamine oxidase B (MAO-B). Pargyline indirectly activates SENP2 by inhibiting MAO-B activity, influencing the desumoylation and stabilization of target proteins. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 is a selective inhibitor of the Jumonji family of histone demethylases. SENP2 is involved in the regulation of histone modifications. JIB-04 indirectly activates SENP2 by inhibiting histone demethylases, creating conditions conducive to SENP2-dependent deSUMOylation events. | ||||||
RSL3 | 1219810-16-8 | sc-507385 | 10 mg | $250.00 | ||
RSL3 is a ferroptosis inducer that inhibits glutathione peroxidase 4 (GPX4). SENP2 has been reported to regulate ferroptosis through its interaction with GPX4. RSL3 indirectly activates SENP2 by inhibiting GPX4, influencing the desumoylation and stabilization of proteins involved in ferroptosis. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide is an anthelmintic drug that has been found to inhibit multiple signaling pathways. SENP2 is known to be involved in the regulation of Wnt/β-catenin signaling. Niclosamide indirectly activates SENP2 by influencing Wnt/β-catenin signaling, leading to alterations in the sumoylation status of proteins involved in this pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. SENP2 is known to modulate NF-κB signaling by desumoylating key components. BAY 11-7082 indirectly activates SENP2 by inhibiting NF-κB activation, leading to alterations in the sumoylation status of proteins involved in NF-κB signaling. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol is a sirtuin inhibitor that affects multiple cellular processes. SENP2 is involved in the regulation of Sirtuin 1 (SIRT1) activity. Sirtinol indirectly activates SENP2 by inhibiting SIRT1, influencing the desumoylation and stabilization of proteins regulated by SIRT1. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
FH535 is a dual inhibitor of Wnt/β-catenin signaling and peroxisome proliferator-activated receptor (PPAR). SENP2 is known to regulate Wnt/β-catenin signaling. FH535 indirectly activates SENP2 by inhibiting Wnt/β-catenin signaling, leading to alterations in the sumoylation status of proteins involved in this pathway. | ||||||