SENP2 Inhibitors
SENP2 inhibitors encompass a range of compounds designed to modulate the deSUMOylation activity of SENP2, a critical regulator of SUMO-dependent cellular processes. Direct inhibitors like ML-792, 2-D08, and CAY10602 specifically target SENP2's catalytic site, preventing the removal of SUMO moieties from target proteins. These inhibitors provide precise tools for investigating the cellular functions regulated by SENP2, particularly those involving SUMOylation-dependent protein interactions and functions. Indirect inhibitors, such as NEM, BAPN, and NSC61610, influence SENP2 by affecting its enzymatic activity through covalent modification or alterations in the cellular redox state. These compounds modulate the overall cellular environment and indirectly impact SENP2 activity, leading to the alteration of cellular processes dependent on SENP2, particularly those influenced by its deSUMOylation activity.
Natural products like Anacardic Acid, Rhein, and 4-Hydroxynonenal (4-HNE) also serve as indirect SENP2 inhibitors by affecting its enzymatic activity through various mechanisms, including interference with acetylation status or modulation of the cellular redox state. These compounds provide additional avenues for exploring the intricate regulatory mechanisms governed by SENP2 in SUMOylation-dependent cellular events. In summary, the diverse SENP2 inhibitors outlined here offer researchers valuable tools to dissect the nuanced roles of SENP2 in cellular processes. Direct and indirect modulation of SENP2 activity enables precise investigations into its impact on SUMOylation-dependent protein functions, contributing to a deeper understanding of the regulatory mechanisms governed by SENP2 in cellular dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-792 | 1644342-14-2 | sc-507423 | 10 mg | $390.00 | ||
ML-792 is a selective small molecule inhibitor of SENP2, directly targeting its catalytic activity. By binding to the active site of SENP2, ML-792 specifically inhibits its deSUMOylation function, preventing the removal of SUMO moieties from target proteins. This direct inhibition leads to the modulation of cellular processes regulated by SENP2, particularly those involving SUMOylation-dependent protein interactions and functions. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
NEM is an alkylating agent that indirectly inhibits SENP2 by covalently modifying cysteine residues. By forming adducts with cysteines in the catalytic site, NEM disrupts the enzymatic activity of SENP2. This indirect inhibition results in the modulation of cellular processes dependent on SENP2, particularly those influenced by its deSUMOylation activity and the consequent regulation of SUMOylated proteins. | ||||||
2-D08 | 144707-18-6 | sc-507405 | 5 mg | $150.00 | ||
2-D08 is a selective small molecule inhibitor of SENP2, directly targeting its catalytic activity. By binding to the catalytic site of SENP2, 2-D08 specifically inhibits its deSUMOylation function, preventing the removal of SUMO moieties from target proteins. This direct inhibition leads to the modulation of cellular processes regulated by SENP2, particularly those involving SUMOylation-dependent protein interactions and functions. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic Acid is a natural product that indirectly inhibits SENP2 by interfering with its enzymatic activity. By influencing the acetylation status of SENP2, Anacardic Acid disrupts its deSUMOylation function. This indirect inhibition results in the modulation of cellular processes dependent on SENP2, particularly those influenced by its SUMOylation-regulating activity and the consequent alteration of SUMOylated protein functions. | ||||||
Rhein | 478-43-3 | sc-205837 sc-205837A | 100 mg 500 mg | $262.00 $326.00 | 2 | |
Rhein is a natural anthraquinone compound that indirectly inhibits SENP2 by affecting its enzymatic activity. By modulating the redox state of the cell, Rhein influences the overall cellular environment and indirectly impacts SENP2 activity. This results in the modulation of cellular processes dependent on SENP2, particularly those influenced by its deSUMOylation activity and the consequent alteration of SUMOylated protein functions. | ||||||
4-Hydroxynonenal | 75899-68-2 | sc-202019 sc-202019A sc-202019B | 1 mg 10 mg 50 mg | $116.00 $642.00 $2720.00 | 25 | |
4-Hydroxynonenal (4-HNE) is a natural product that indirectly inhibits SENP2 by affecting its enzymatic activity. As a lipid peroxidation product, 4-HNE modulates the overall cellular redox state, indirectly impacting SENP2 activity. This results in the modulation of cellular processes dependent on SENP2, particularly those influenced by its deSUMOylation activity and the consequent alteration of SUMOylated protein functions. | ||||||