Molecular structure of 2-D08, CAS Number: 144707-18-6
2-D08 (CAS 144707-18-6)
Alternate Names:
2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number:
144707-18-6
Molecular Weight:
270.2
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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2-D08 (CAS 144707-18-6) References
- Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08). | Marsh, DT., et al. 2017. Bioorg Med Chem. 25: 3827-3834. PMID: 28559058
- K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion. | Choi, BH., et al. 2018. J Biol Chem. 293: 17574-17581. PMID: 30228186
- 2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2. | Zhou, P., et al. 2019. Biochem Biophys Res Commun. 513: 1063-1069. PMID: 31010676
- 2-D08 treatment regulates C2C12 myoblast proliferation and differentiation via the Erk1/2 and proteasome signaling pathways. | Liu, H., et al. 2021. J Muscle Res Cell Motil. 42: 193-202. PMID: 34142311
- The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an in vitro intestinal mucositis model. | Marsh, DT. and Smid, SD. 2022. Food Funct. 13: 11142-11152. PMID: 36205567
- UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer. | Xiao, J., et al. 2023. J Clin Invest. 133: PMID: 36626227
- SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways. | Tan, D., et al. 2023. Nat Commun. 14: 3887. PMID: 37393345
- Deficiency of protein inhibitor of activated STAT3 exacerbates atherosclerosis by modulating VSMC phenotypic switching. | Liu, H., et al. 2023. Atherosclerosis. 380: 117195. PMID: 37586220
- Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression. | Wang, Y., et al. 2024. Cancer Biol Ther. 25: 2323768. PMID: 38465861
- 2‑D08 mediates notable anticancer effects through multiple cellular pathways in uterine leiomyosarcoma cells. | Joung, H. and Liu, H. 2024. Oncol Rep. 52: PMID: 38874019
Inhibitor of:
14-3-3 ε, 4930444G20Rik, C9orf173, cGKII, CXorf23, EG408191, H2-Db, PIASy, RNF150, SENP (SUMO specific peptidase), SENP2, SENP3, SUMF1, SUMO-1, SUMO-2, SUMO-3, SUMO-4, UBA2, UBC9, and Ubiquitin conjugating enzyme E2 (UBE2).Activator of:
AOS-1, CSN7b, and Herc5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-D08, 5 mg | sc-507405 | 5 mg | $150.00 |