Date published: 2025-10-15

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Pargyline hydrochloride (CAS 306-07-0)

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Application:
Pargyline hydrochloride is an irreversible MAO-B inhibitor
CAS Number:
306-07-0
Purity:
>98%
Molecular Weight:
195.69
Molecular Formula:
C11H13N•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pargyline hydrochloride functions as a monoamine oxidase inhibitor. It acts by irreversibly inhibiting the enzyme monoamine oxidase, which is responsible for the metabolism of neurotransmitters such as serotonin, dopamine, and norepinephrine. By inhibiting this enzyme, pargyline hydrochloride increases the levels of these neurotransmitters in the synaptic cleft, leading to enhanced neurotransmission. Pargyline Hydrochloride targets the active site of monoamine oxidase, forming a covalent bond with the enzyme and preventing it from carrying out its normal metabolic function. This mechanism of action results in an accumulation of neurotransmitters in the synaptic cleft, ultimately affecting neuronal signaling and communication. Pargyline hydrochloride can be used to investigate the role of monoamine oxidase in neurotransmitter metabolism and to study the effects of altered neurotransmitter levels on neuronal function.


Pargyline hydrochloride (CAS 306-07-0) References

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  2. A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.  |  Lin, CL., et al. 2019. EMBO Mol Med. 11: PMID: 30948420
  3. Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products.  |  van der Toorn, M., et al. 2019. Toxicol Rep. 6: 1206-1215. PMID: 31768332
  4. Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice.  |  Bayo-Olugbami, A., et al. 2022. Nutr Neurosci. 25: 823-834. PMID: 32912107
  5. Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT7 Receptor.  |  Tempio, A., et al. 2020. Int J Mol Sci. 21: PMID: 33348850
  6. The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB.  |  An, H., et al. 2021. Exp Neurobiol. 30: 113-119. PMID: 33972465
  7. Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis.  |  Yao, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35628342
  8. Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.  |  Vegas-Suárez, S., et al. 2022. Front Pharmacol. 13: 953652. PMID: 36133803
  9. DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson's Disease Rat Model.  |  Zhang, L., et al. 2022. Parkinsons Dis. 2022: 1428817. PMID: 36419409
  10. Uptake and Metabolization of Serotonin by Granulosa Cells Form a Functional Barrier in the Mouse Ovary.  |  Alyoshina, NM., et al. 2022. Int J Mol Sci. 23: PMID: 36499156
  11. LUHMES Cells: Phenotype Refinement and Development of an MPP+-Based Test System for Screening Antiparkinsonian Drugs.  |  Beliakov, SV., et al. 2023. Int J Mol Sci. 24: PMID: 36614176
  12. Pargyline hydrochloride combined with methyclothiazide in the treatment of hypertension.  |  Waldmann, EB. and Nickas, G. 1967. Ariz Med. 24: 343-6. PMID: 6046398

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pargyline hydrochloride, 500 mg

sc-215676
500 mg
$39.00

Pargyline hydrochloride, 1 g

sc-215676A
1 g
$82.00