Molecular structure of C646, CAS Number: 328968-36-1
C646 (CAS 328968-36-1)
See product citations (5)
Alternate Names:
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Application:
C646 is a selective p300, CBP, histone H3 and H4 inhibitor
CAS Number:
328968-36-1
Purity:
≥98%
Molecular Weight:
445.42
Molecular Formula:
C24H19N3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
C646 is a compound used in biochemical research, particularly as a tool for studying the regulation of gene expression. It acts as a selective inhibitor of p300, a histone acetyltransferase enzyme, which plays a critical role in the acetylation of histones, affecting chromatin structure and gene transcription. By inhibiting this enzyme, C646 allows researchers to investigate the consequences of reduced histone acetylation on gene activity and cellular processes. In molecular biology, the compound is applied to study the mechanism of epigenetic modifications and their effect on various signaling pathways. Additionally, C646 is utilized in the field of cell biology to explore the impact of these epigenetic changes on cell differentiation and proliferation. The compound′s utility extends to the examination of transcription factors and other proteins that interact with p300, furthering the understanding of their function and regulation.
C646 (CAS 328968-36-1) References
- A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. | Gao, XN., et al. 2013. PLoS One. 8: e55481. PMID: 23390536
- C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. | Oike, T., et al. 2014. Radiother Oncol. 111: 222-7. PMID: 24746574
- Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. | Yang, Y., et al. 2015. Int J Clin Exp Pathol. 8: 2746-54. PMID: 26045780
- C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection. | Zhao, D., et al. 2015. Antimicrob Agents Chemother. 60: 1902-6. PMID: 26711748
- The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases. | van den Bosch, T., et al. 2016. Biochem Pharmacol. 102: 130-140. PMID: 26718586
- Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300. | Shrimp, JH., et al. 2016. ACS Med Chem Lett. 7: 151-5. PMID: 26985290
- Selective p300 inhibitor C646 inhibited HPV E6-E7 genes, altered glucose metabolism and induced apoptosis in cervical cancer cells. | He, H., et al. 2017. Eur J Pharmacol. 812: 206-215. PMID: 28619596
- Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines. | Wang, YM., et al. 2017. Int J Oncol. 51: 1860-1868. PMID: 29075795
- CBP/p300 inhibitor C646 prevents high glucose exposure induced neuroepithelial cell proliferation. | Bai, B., et al. 2018. Birth Defects Res. 110: 1118-1128. PMID: 30114346
- C646 modulates inflammatory response and antibacterial activity of macrophage. | Fang, F., et al. 2019. Int Immunopharmacol. 74: 105736. PMID: 31302452
- Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells. | Wang, Z., et al. 2021. Cell Cycle. 20: 392-405. PMID: 33487075
- C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer. | Ono, H., et al. 2021. Sci Rep. 11: 10078. PMID: 33980911
- C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome. | Xu, X., et al. 2021. Front Pharmacol. 12: 707610. PMID: 34322027
- The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor. | Peng, J., et al. 2022. J Biol Chem. 298: 101621. PMID: 35074429
Inhibitor of:
1200013P24Rik, 2200001I15Rik, 2610305D13Rik, 2700081O15Rik, 4632411B12Rik, 4930557A04Rik, A-Myb, Abi-2, ACF, ACTL7A, ADA3, AFF4, ALF, ANKDD1A, ANKRD24, ARID2, ARID3C, ATF-7, B-Myc, BAF170, BAF53B, BAF60a, BAZ2B, BC066135, BC094916, BC100530, BC106175, Bdf1, Blimp-1, C1orf181, CA150, CaBP3, CAF-1 p150, CD92, CHD7, CMTM5, CNOT7, Coronin 2B, CREB Binding Protein (CBP), D3Ertd254e, D3Ertd751e, D5Ertd577e, DPF3, E130012A19Rik, E130309D02Rik, E430018J23Rik, EG224763, EG225058, EG236663, EG240038, EG333452, EG382639, EG384244, EG432879, EG436188, EG545802, EG546205, Elongin A3, Elongin C, ELP4, ER81, ERBIN, ESCO1, FAM119A, FAM136A, Fam48b1, FBXW18, FBXW24, Forkhead box N (FOXN), FOXD4L3, FOXN1, FRYL, GLT8D3, Gm608, Gm806, GMEB-2, GPR33, GSDMC4, H2afb2, HAT1, HBO1, hCG_1795065, hCG_2023776, HEB, Hemoglobin δ, HESL, HIGD1C, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AE, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AL, Histone cluster 1 H2AM, Histone cluster 1 H2BA, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BD, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3F, Histone cluster 1 H4I, Histone cluster 2 H2AA1, Histone cluster 3 H2BB, Histone H2A.Z, Histone H3.3A, HLF, HMP-2, INO80C, Integrin αIIIb, Kctd12b, Khdc1a, KIR2DL3, kleisin β, Krox-8, KRTAP13-3, Lce1g, LNX2, LOC100039763, LOC100039799, LOC100040458, LOC100040962, LOC100041296, LOC150383_2210021J22Rik, LOC283547, LOC340094, LOC439994, LRRC3, lysine, MacroH2A2, MAGE-A10, MAGE-G2, Matrin-3, Mi2-β, MOF, MORF, MOZ, MSL3L1, MTF-2, Munc13-2, MYBBP1A, N-CoR, NAA (N-alpha-acetyltransferase), NAP1L5, NAP5, NAT-11, NAT-13, NAT-3, NBPF8, Ndfip1, NELF, NOPAR, NTS12, Osteoadherin, OTTMUSG00000010747, OTTMUSG00000016784, p300, p400, PABP, PABPC2, PABPC3, PABPC4, PABPC6, Paf1, PCAF, PCDHGA1, PCDHGB5, PGRMC1, PHC2, PHF16, PHF6, PHR1, PHTF1, PLAC8, PLAG1, Plectin, POU6F2, PRDM6, PREP-1, PRHOXNB, RBM42, RCOR2, RFX8, RICS, RNF10, RNF17, RNF186, RNF20, RNF6, SBNO2, SCML1, Set2, SET7/9, SIAH-1B, Six3, Snf5, Sox-14, Sp4, Sp8, SPT6, SRCAP, SRGAP2P1, ST7, STOX2, SUR-2, Swi3, TADA2L, TAF II p130, TAF II p150, TAF5L, TAF6L, TDRD12, THAP7, TMEM103, TMEM108, TMEM59, TMEM98, Tollip, TRAF5, transgelin-3, TRIM12, TRIM27, TRRAP, TSHZ2, TSPYL6, Tup1, Ula1, UNQ6126, USP17L5, v-Myb, VPS72, WCRF, WDR33, WDR5, WDTC1, ZBTB44, ZCCHC17, Zic1, ZKSCAN1, ZMYND12, ZNF205, ZNF268, ZNF274, ZNF323, ZNF38, ZNF434, ZNF454, ZNF500, ZNF518B, ZNF533, ZNF588, ZNF629, ZNF641, ZNF648, ZNF674, ZNF71, ZNF84, ZNF843, ZSCAN4B, ZSWIM3, and ZZZ3.Activator of:
4632411B12Rik, ACTR6, ASCL2, Brpf1, C11orf41_D430041D05Rik, C87499, C87977, CARM1, CDY, CECR2, Chromodomain Helicase DNA binding protein (CHD), DUB1, ECOP, EG240038, EG278167, EG434727, EG625480, ELL, ELL2, EPC1, ephrin-B1, Esa1, Ets-1, Fbxw21, HAT1, HDA2, Histone cluster 1 H1T, Histone cluster 1 H2BH, Histone cluster 1 H3C, Histone H2BM, Histone H3.3B, HKDC1, INTS4, Josephin-3, Khdc1b, L3MBTL3, LRRC4B, LRRC8E, MacroH2A, MacroH2A1, Mad 1, MEAF6, Med19, megalin, Miz-1, MORF4L1, Mot1, MRG15, Mxi1, Myocardin, NAT-12, NDRG2, p300, PARG, Peregrin, periphilin 1, PHF7, Pinin, POLR2D, PRDM14, Rad21, Rad23B, RNF20, RPRD2, RTF1, SA-2, SENP2, SETD6, SIV-1 Nef, SLUG, Smurf2, SSU72, STH1, StIP1, TAF II p135, TAF9A, Tctex1D1, TLE4, YAF2, Zfp874, ZNF226, ZNF408, and ZNF620.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C646, 10 mg | sc-364452 | 10 mg | $260.00 | |||
C646, 50 mg | sc-364452A | 50 mg | $925.00 |