C646 CAS: 328968-36-1
MF: C24H19N3O6
MW: 445.42
A selective p300, CBP, histone H3 and H4 inhibitor.

C646 (CAS 328968-36-1)

C646 | CAS 328968-36-1 is rated 5.0 out of 5 by 1.
  • y_2020, m_2, d_17, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364452, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 134ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Application: A selective p300, CBP, histone H3 and H4 inhibitor
CAS Number: 328968-36-1
Purity: ≥98%
Molecular Weight: 445.42
Molecular Formula: C24H19N3O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

C 646 is a selective p300/CREB-binding (CBP) inhibitor with a Ki value of 400 nM. C 646 also inhibits histone H3 and H4 acetylation in mouse fibroblast cell lines.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), DMF (~1.5 mg/ml), and DMSO:PBS(1:1, pH 7.2) (~0.5 mg/ml).
Storage :
Desiccate at 4° C
Melting Point :
224-226° C
Boiling Point :
~662.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
p300: IC50 = 400 nM (human)
Ki Data :
p300: Ki= 400 nM (human)
pK Values :
pKa: 4.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
1285941
MDL Number :
MFCD01784780
SMILES :
CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

C646  Product Citations

See how others have used C646. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29433067  2018. Mol. Immunol. 95: 99-106.

PMID: # 30352365  2018. Mol. Immunol. 103: 312-321.

PMID: # 28578223  Shii, L.|Song, L.|Maurer, K.|Zhang, Z.|Sullivan, KE.| et al. 2017. Mol. Immunol. 88: 20-31.

Citations 1 to 3 of 3 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. C646, sc-364452, is a crystalline solid.
Answered by: Chemical Support 4
Date published: 2017-03-30

I wanted CREB inhibitors in pathologic pain signaling pathways, and I would like to know if this product would be able to meet my requirement? Thank you!

Asked by: two2igm05
Thank you for your question. C646, sc-364452, is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). It is also selective against six other histone acetyltransferases (HATs) and suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.
Answered by: TechService7
Date published: 2016-12-15
  • y_2020, m_2, d_17, h_15CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_364452, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 141ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Gaddis et al Gaddis et al. (PubMed ID 26191083) used C646 to competitively inhibit acetyl CoA binding in cancer transcriptomes. -SCBT Publication Review
Date published: 2015-01-08
  • y_2020, m_2, d_17, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364452, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 13ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.