S-Myc Activators
S-Myc Activators are a varied group of chemical compounds that indirectly bolster the functional activity of S-Myc through distinct signaling pathways. Forskolin, by raising intracellular cAMP levels, indirectly bolsters S-Myc's functional role by activating PKA, which can phosphorylate substrates that enhance S-Myc's activity in cellular metabolism and growth. Prostaglandin E2 and Isoproterenol both function similarly, through G-protein coupled receptor pathways, to increase cAMP and PKA activity,which subsequently influences the transcriptional activity of S-Myc by coactivating MYC-related gene expression. Dibutyryl cAMP, a cAMP analog, and Phorbol 12-myristate 13-acetate (PMA), a PKC activator, both enhance S-Myc's activity by phosphorylating proteins within S-Myc's regulatory network, supporting S-Myc's role in cellular signaling and proliferation. Retinoic acid and Epidermal Growth Factor (EGF) also contribute to S-Myc activation by binding to their respective receptors, leading to gene expression changes that complement S-Myc's functions in cellular differentiation and survival. Trichostatin A, by altering chromatin structure, and Sodium Butyrate, through its histone deacetylase inhibition, both facilitate an environment where S-Myc's transcriptional activity is heightened.
Additionally, Lithium chloride and Nicotinamide both indirectly enhance S-Myc's activity by modulating the stability and function of interacting proteins within pathways such as Wnt signaling and cellular metabolism. Curcumin uniquely contributes by inhibiting competitive NF-κB signaling, thereby indirectly promoting S-Myc's associated proliferative signals. Collectively, these compounds, through their targeted biochemical actions, serve to potentiate the cellular functions mediated by S-Myc without the need to directly upregulate its expression or activation. Each activator, by influencing specific pathways or molecular mechanisms, converges to enhance the role of S-Myc in critical cellular processes like growth, metabolism, and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins that may be involved in the same pathways as S-Myc, thus potentially enhancing S-Myc's functional activity related to cellular growth and metabolism. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to EP2 and EP4 receptors, which activates adenylate cyclase and increases cAMP levels. This in turn can activate PKA and CREB, a transcription factor that can enhance the transcriptional activity of S-Myc by coactivating MYC-related gene expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, leading to increased cAMP and PKA activation. PKA can phosphorylate various proteins that interact with S-Myc, enhancing its activity in processes such as cell growth and proliferation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Dibutyryl cAMP is a cell-permeable cAMP analog that directly activates PKA. Activated PKA can then phosphorylate substrates that may interact with S-Myc, leading to an increase in S-Myc activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and modulate proteins that are part of the S-Myc regulatory network, thereby enhancing S-Myc's role in cellular signaling and proliferation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, which can regulate gene expression. This can lead to changes in the expression of genes that are co-regulated by S-Myc, thus indirectly influencing S-Myc's activity in cellular differentiation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can cause chromatin remodeling and affect the accessibility of transcription factors like MYC to their target DNA, leading to enhanced S-Myc activity through transcriptional regulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3, which can lead to stabilization and enhanced activity of proteins that interact with S-Myc, potentially increasing S-Myc's activity in Wnt signaling pathways. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide inhibits sirtuins, which are NAD+-dependent deacetylases. This inhibition can modify the activity of proteins that regulate the function of S-Myc, potentially enhancing S-Myc's role in cellular metabolism and stress responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which may lead to a reduction in cellular proliferation signals that oppose the function of S-Myc. This can indirectly enhance the functional activity of S-Myc by reducing competitive signaling pathways. | ||||||