RSAD2 Inhibitors
RSAD2 Inhibitors belong to a distinct chemical class that focuses on targeting a specific protein known as RSAD2, which plays a crucial role in the innate immune response of mammals. RSAD2, also referred to as viperin, is an interferon-stimulated gene (ISG) that is upregulated in response to viral infections. This protein is primarily found in the endoplasmic reticulum and acts as a potent antiviral factor by inhibiting the replication of various viruses, including influenza, hepatitis C, and HIV. RSAD2 achieves this inhibitory effect by disrupting the lipid metabolism of the host cell, thereby interfering with the production of viral particles.
Chemical compounds classified as RSAD2 inhibitors are designed to specifically target RSAD2 and modulate its activity. These inhibitors typically work by binding to RSAD2 or its associated signaling pathways, either promoting its antiviral functions or suppressing its activity. The development of RSAD2 inhibitors is of particular interest in the field of virology and immunology, as they have the potential to enhance our understanding of the host-virus interaction and contribute to the development of novel antiviral strategies. Additionally, RSAD2 inhibitors can serve as valuable tools for researchers studying the innate immune response and its role in protecting the host organism against viral infections, offering insights into the broader field of immunology and infectious diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can indirectly affect RSAD2 by altering gene expression patterns, including those involved in immune responses which could modulate RSAD2 activity. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An NF-κB pathway inhibitor, which can indirectly reduce RSAD2 expression by inhibiting a pathway involved in its regulation, particularly in immune response scenarios. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
An inhibitor that blocks NF-κB nuclear translocation, potentially decreasing RSAD2 expression by inhibiting NF-κB-dependent signaling pathways. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
An IKK-2 inhibitor, which acts on the NF-κB pathway. By inhibiting this pathway, TPCA-1 can reduce the expression of RSAD2, which is often upregulated in response to NF-κB activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor, potentially affecting RSAD2 expression by modulating stress and immune response pathways where JNK signaling is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, which could indirectly affect RSAD2 activity by modulating PI3K/Akt signaling pathways involved in immune responses and cellular stress, pathways known to influence RSAD2 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor, which can potentially decrease RSAD2 expression by affecting the MEK/ERK pathway, a crucial part of the signaling involved in immune and stress responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor, which may indirectly inhibit RSAD2 by modulating the PI3K/Akt pathway, thereby influencing pathways that regulate RSAD2 expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor, which can influence RSAD2 expression by inhibiting p38 MAPK pathway involved in cellular stress response and cytokine production. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
A flavonoid that can inhibit NF-κB activation, potentially leading to a decrease in RSAD2 expression, as NF-κB is a known regulator of RSAD2 in response to immune stimuli. | ||||||