Molecular structure of NFκB Activation Inhibitor II, JSH-23, CAS Number: 749886-87-1
NFκB Activation Inhibitor II, JSH-23 (CAS 749886-87-1)
See product citations (34)
Alternate Names:
4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine; JSH-23
Application:
NFκB Activation Inhibitor II, JSH-23 is an inhibitor of NF-κB transcriptional activity
CAS Number:
749886-87-1
Purity:
≥95%
Molecular Weight:
240.30
Molecular Formula:
C16H20N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NFκB Activation Inhibitor II, also known as JSH-23, is a chemical compound widely used in molecular biology and immunology research to study the NF-κB signaling pathway, a key regulator of immune response, inflammation, and cell survival. NFκB Activation Inhibitor II, JSH-23 is specifically recognized for its ability to inhibit the nuclear translocation of NF-κB without affecting its DNA-binding activity, providing a targeted approach for dissecting the pathway′s components and functions. This selective inhibition makes it an invaluable tool for researchers aiming to understand the role of NF-κB in gene expression and to delineate its contribution to inflammatory and autoimmune responses. Additionally, the compound is utilized to examine the cross-talk between NF-κB and other signaling cascades, further elucidating its role in cellular processes.
NFκB Activation Inhibitor II, JSH-23 (CAS 749886-87-1) References
- Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. | Shin, HM., et al. 2004. FEBS Lett. 571: 50-4. PMID: 15280016
- Rosiglitazone suppresses lipopolysaccharide-induced matrix metalloproteinase-2 activity in rat aortic endothelial cells via Ras-MEK1/2 signaling. | Wu, X. and Li, L. 2012. Int J Cardiol. 158: 54-8. PMID: 21247645
- JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence. | Kumar, A., et al. 2011. Diabetes Obes Metab. 13: 750-8. PMID: 21447040
- JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus. | Wang, Q., et al. 2018. Pharmacol Biochem Behav. 169: 59-66. PMID: 29684396
- ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury. | Peng, X., et al. 2019. Cell Death Dis. 10: 253. PMID: 30874544
- NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling. | Chen, X., et al. 2019. Cell Death Dis. 10: 906. PMID: 31787755
- Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma. | Kunze, B., et al. 2020. Gastroenterology. 159: 575-590. PMID: 32325086
- Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress. | Peng, D., et al. 2020. J Neuroinflammation. 17: 343. PMID: 33203418
- The Novel Antioxidant Compound JSH-23 Prevents Osteolysis by Scavenging ROS During Both Osteoclastogenesis and Osteoblastogenesis. | Mei, L., et al. 2021. Front Pharmacol. 12: 734774. PMID: 34566656
- Macrophage Polarization Modulated by NF-κB in Polylactide Membranes-Treated Peritendinous Adhesion. | Wang, S., et al. 2022. Small. 18: e2104112. PMID: 34816589
- METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice. | Yang, L., et al. 2022. Cell Death Discov. 8: 62. PMID: 35165276
- Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI. | Li, T., et al. 2022. Cell Death Discov. 8: 61. PMID: 35165294
- Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis. | Li, X., et al. 2022. Pharmacol Res. 183: 106368. PMID: 35905891
Inhibitor of:
β-defensin 18, β-defensin 9, Abin-3, AMCase, ANKRD29, ANKRD44, B7-H3, C1orf62, C2orf48, C6orf81, C7orf52, CARD 6, CARD 9, CARD14, CLEC-2L, EG434219, EG623459, EG624439, EG624584, FLJ37396, FLYWCH2, FOXC1, FOXM1, gasdermin C, GROα_KC, hCG_1657980, HHV-4 LMP-1, HRF, IκB-α, IκB-ζ, IκB-pp40, IDE, IFIX, IFN-α16, IL-17C, IL-17R, IL-17RA, IL-17RC, IL-1RAcP, IL-23R, Il-28a, IL-28B, IL-32, IL-TIF, IRF-3, IRF-7, Klotho, LHPP, LOC730060, LRRC10B, LURAP1L, lymphotactin, LYSMD4, MD-1, NAIP1, NAIP5, NAIP6, NAIP7, NALP4C, NALP9B, NF kappa B, NF-1C, NFκB p50, NFKBIL2, NKp44, NKRF, Nlrp12, OCIL, Olfr478, Olfr479, Olfr55, Olfr550, Olfr552, Olfr845, Olfr846, Olfr908, Olfr909, Olfr91, Olfr910, Olfr912, Olfr913, Olfr914, p100, p105, p8, Pilr-β1, PLAA, PPX, Ran GAP1, RelB, RELL1, RSAD2, SAA2, SIMPL, SPATA2, STAP-2, TALL-1, TANK, TBKBP1, THP, TL, TNIP2 (Abin-2), TRAF2, TRAF4, TRAF5, TRAFD1, TREM-3, TRIM14, TRIM30C, TRIM43A, TRIM56, TWEAK, V1RD17, Veli2, ZHX1, ZNF683, and ZNFX1.Activator of:
Abin-1, ANKRD24, BC068157, BC094916, CMV pp65, EG546272, EG546282, EG623459, Factor B, FLIPL, GBDR1, Gm4788, HSV-1 ICP0, IRF-2BP2, KLF16, LOC391722, Ly-6G, MAP-1B, MCP-1, Olfr787, PIAS 3, RAG-2, syntenin-1, T54, Tak1, TRIM7, TrpRS, and TRUNDD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFκB Activation Inhibitor II, JSH-23, 5 mg | sc-222061 | 5 mg | $214.00 | |||
NFκB Activation Inhibitor II, JSH-23, 10 mg | sc-222061C | 10 mg | $257.00 | |||
NFκB Activation Inhibitor II, JSH-23, 50 mg | sc-222061A | 50 mg | $1775.00 | |||
NFκB Activation Inhibitor II, JSH-23, 100 mg | sc-222061B | 100 mg | $2003.00 |