Molecular structure of Apigenin, CAS Number: 520-36-5
Apigenin (CAS 520-36-5)
See product citations (22)
Alternate Names:
Apigenin is also known as 4,5,7-Trihydroxyflavone.
Application:
Apigenin is an antiinflammatory flavonoid compound casein kinase II inhibitor found in many fruits and vegetables.
CAS Number:
520-36-5
Purity:
≥98%
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Apigenin is an antioxidant plant flavanoid which contains anti-inflammatory and anticancer properties. Apigenin may induce apoptosis and may inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Apigenin is also known to be a MAP kinase inhibitor and a selective inhibitor of Protein Kinase 2 (CK2). Apigenin is capable of exerting diverse effects on a vast variety of molecular targets. Most effects of Apigenin appear to be mostly mediated through suppressing nitric oxide synthase-2 (NOS2), Hypoxia-inducible factor 1 alpha (HIF-1 alpha), lipoxygenase, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression. Apigenin blocks proliferation of Wnt-1 transfected cells, dephosphorylates beta-catenin and lowers levels of beta-catenin and Dvi.
Apigenin (CAS 520-36-5) References
- Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. | Liang, YC., et al. 1999. Carcinogenesis. 20: 1945-52. PMID: 10506109
- Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. | Song, DH., et al. 2000. J Biol Chem. 275: 23790-7. PMID: 10806215
- Comparative effects of three nitrosourea derivatives on mammalian cell cycle progression. | Tobey, RA. and Crissman, HA. 1975. Cancer Res. 35: 460-70. PMID: 1167349
- Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. | Fang, J., et al. 2005. FASEB J. 19: 342-53. PMID: 15746177
- Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. | Yamada, M., et al. 2005. Proc Natl Acad Sci U S A. 102: 7736-41. PMID: 15897466
- Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. | Shukla, S. and Gupta, S. 2006. Mol Cancer Ther. 5: 843-52. PMID: 16648554
- Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. | Fang, J., et al. 2007. Carcinogenesis. 28: 858-64. PMID: 17071632
- Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. | Ujiki, MB., et al. 2006. Mol Cancer. 5: 76. PMID: 17196098
- Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | Feng, X., et al. 2017. Biochem Pharmacol. 136: 136-149. PMID: 28414138
- Apigenin prevents gamma radiation-induced gastrointestinal damages by modulating inflammatory and apoptotic signalling mediators. | Begum, N., et al. 2022. Nat Prod Res. 36: 1631-1635. PMID: 33673794
- Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis. | Li, BS., et al. 2021. Am J Chin Med. 49: 1235-1250. PMID: 34049472
- Neuroprotective Effect of Apigenin on Depressive-Like Behavior: Mechanistic Approach. | Bijani, S., et al. 2022. Neurochem Res. 47: 644-655. PMID: 34705188
- Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway. | Hsu, MC., et al. 2021. J Food Drug Anal. 29: 240-254. PMID: 35696209
- Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway. | Jin, Z., et al. 2022. CNS Neurosci Ther. 28: 1883-1894. PMID: 35906830
- Apigenin inhibits infectious bronchitis virus replication in ovo. | Saadh, MJ., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 5367-5371. PMID: 35993630
Inhibitor of:
α4-crystallin, β-defensin 121, β-defensin 129, β-defensin 134, β-defensin 136, β-defensin 3B, β-defensin 41, β-synuclein, δ-FR, γ-casein, 1110001A16Rik, 1110017F19Rik, 1190007F08Rik, 15-LO, 1600014C23Rik, 17β-HSD4, 1700008P20Rik, 1700017D01Rik, 1700023F06Rik, 1700026J04Rik, 1700129C05Rik, 1810024B03Rik, 2010002M12Rik, 2010315B03Rik, 2210010C04Rik, 2210016F16Rik, 2210020M01Rik, 2300003K06Rik, 2410017P09Rik, 4930415L06Rik, 4930428E23Rik, 4930467E23Rik, 4930523C07Rik, 4930579G24Rik, 5830411N06Rik, ABCG1, AK5, ANG V, Angptl4, Annexin III, APC4, API5, APOBEC3D, ARL7, Baff, BATF2, BCRF1, Bikunin, BST-1, C/EBP ζ, C15orf41, C1orf210, C4orf47, C5orf23, C5orf24, C8orf42, C8orf47, cadherin-22, CAP-18, CAPSL, CapZ-3, Carcinoma marker, Casein Kinase, Casein Kinase II, casein kinase II alpha, casein kinase IIβ, CCDC11, CCL12, CCL16, CCL28, CD16-2, CD16-A, CD62L ligand, CD8α, CD96, Cdx1, CDY1, Chemokine Receptor D6, CILP, Ckt2, CNG-2, CPVL, CRF21, CRISP-1, CRY1, CSNK1A1L, CSS2, CTAP-III, CTLA-2β, CTLA-4, CXorf30, CXorf51, CYLC1, CYP19, CYP2C9, DC-LAMP, DC-SIGN, DC-SIGN/CD209, Dcun1D2, DDT, DDX60L, DPCD, DTHD1, DUSP4, EBV gp220, EG574081, eIF3α, ERK, ESAT6, EVI5L, Factor H, FBXO33, Fbxw12, FIV p27, FLRT1, FN3K, FOXD4L2-6, Gα gust, G6pd2, galectin-3, galectin-9, GILZ, Glucose-6-Phosphate Dehydrogenase, Glut11, Glut14, Glut5, Glut7, Glut8, GLYCTK, Gm10471, Gm14195, GON4L, GPD2, GPIHBP1, GPR33, GRK 5, GRO, GRXCR2, GSDMC3, H-ficolin, H2-Abβ, H2-Eκ, HAS2, Heme Oxygenase 2, HEXIM1, Hint1, HISPPD1, HIV-1 Gag, HIV-1 Vpr, HNP, HSF1, HSP 105, HSP 47, HYAL3, ICAM-4, IEX-1, IFITM6, IFN-α10, IFN-α11, IFN-α7, IFN-κ, IFRD1, IgE Chain C, IGFBP2, IIGP, IL-1ε F6, IL-10Rα, IL-12, IL-12B p70, IL-13, IL-18, IL-18Rβ, IL-1F10, IL-27Rα, IL-28B, IL-3β, IL-33, IL-8RA, IL-TIFb, Integrin α4β7, Integrin β3, ISGF-3γ p48, Keratin 75, KLHL32, Klk1b3, Krox-8, KRTAP5-11, lactoferrin, LAF4, LCE2D, LCE3A, LCE3B, Lipocalin-12, Lipocalin-6, Lipocalin-8, LIR-7, LOC402377, LRRC3B, MAdCAM, Mast Cell Protease 1, MBP, MCP-4, MDA5, Measles H, Measles NP, MHC class II DQ, MIP-2α, MOV10, MS4A7, MTCP-1, Mucin, Naglt1c, NALP5, NALP6, NCoA-3, NEI, NHSL2, Ninjurin-1, NNT-1/BSF-3, Nucling, OGG1, Olfr382, Olfr976, OTTMUSG00000010546, Ovalbumin, P2X5, PATE3, PC1, PDDC1, PEA3, PEBP-4, Periostin, PGP-I, PGRP-Iα, PI 3-kinase p85β, Pim-2, Plasmacytoid DC Marker, PLP-Cγ, PLUNC, prefoldin 2, Psg19, Psg21, Psg23, Psg25, Psg26, Psg27, Psg28, Psg29, PSGL-1, PSP94, Ptx3, Rabies Virus, RAO, RAP1, RBMS3, RCK, Reg Iα, Reg Iβ, resistin-like γ, Retnlb, Rev-erbα, RFT1, RFX6, RGD1304773, RGD1309106, RGD1309170, Rhox6, Rhox7, RP11-307F22.3, RSAD2, SAA4, SAP-1, SDR-O, Ser/Thr Protein Kinase, SerpinB12, SerpinB9e, sFlt-1, Sg III, SGLT-3, SKN-1, SLC-1, SLC43A1, Slfn1, SMPDL3B, Speedy C, SR-A, SRC-1, SULT2A5, SULT2B10, SULT5A1, Sval1, Tas2r102, Tas2r114, Tas2r140, Tas2r143, Tenr, TEX24, Thrombospondin 2, TKTL2, TLR12, TMPRSSs8, TNF Superfamily (TNFSF), TNF-IP 1, tNOX, Tom1, Tpbpb, TRAIL, TReP-132, Tryptase, Tryptase ε, TYW1B, U2AF26, UGRP2, UGT2B37, UGT2B5, Urease alpha, V1RC20, V1RC21, V1RC23, V1RC26, V1RC28, V1rc29, V1RC33, V1rc7, V1RG11, vanin-3, VEGI, Vmn2r113, VSTM4, Xlr3c, Xlr4a, Xlr4c, Xlr5a, Xlr5b, Xlr5c, Ythdc1, YY2, ZBED5, ZC3H6, ZFP169, ZFP773, Zfp872, ZNF101, ZNF132, ZNF470, ZNF610, ZNF737, and ZSCAN4F.Activator of:
α2ML1, β-defensin 46, β-Glucoronidase, AMPD1, Annexin I, apoE, ARGFX, Bclp2, BMP-7, BRD2, C11orf59, C1rb, C330021F23Rik, CALCA, casein kinase IIα′, CD40L, Cdc26, Cdc53, CKIP-1, cPKC α, creatine kinase-M, CTL4, CYP2A7, CYP2C19, DBC1, DCIR, Dectin-2, DNA pol ε, DNAH2, DnaJB3, Ear1, EG434008, ER beta, EYA3, FAM111B, FAM194A, Fc γ RIIb, FGF-15, GABP-β1, GALC, GBDR1, Gle1, GLIPR1, GPR172A, H2-Q8, hDcp1b, HHV-4 EBNA-3A, HHV-4 EBNA-LP, HMG-17, I2PP2A, IFN-α7, IFN-τ, IL-11Rα2, IL-13Rα1, IL-17R, IL-17RB, IL-22R 1, IL-31, IL-31R, Integrin αL, IP-10, JWA, KIAA0090, KLHL38, KRTAP1-3, KRTAP16-5, KRTAP2-4, LOC100040722, LOC100040857, LRP1B, LRRC33, LSECtin, Ly6g, MALT1, MBIP, MBPH, MEK-4, MEK-6, MGA, MrgA5, MSH2_Msh2, NAB1, NALP9A, neuroguidin, Nurr1, Oas1f, Olfr710, Olfr711, Olfr713, OR11L1, OR5H6, OSC, OTTMUSG00000011290, OTTMUSG00000011291, OTTMUSG00000011339, OTTMUSG00000011350, PARP-12, PI 3-kinase p85110, PIASx, PLEKHN1, Pyrin, RBM10, reaper, RTCD1, S100A7A, SCOCO, SEEK1, SERCA1, SerpinA3j, SerpinB6e, SETX, SIRT5, Slfn2, SPOP, SULT2A5, SULT2A7, TBC1D3C, TFIIH p44, TGase4, TGIF2LX2, TMCO7, TMPRSS11D, UNC-5, USP29, Vitronectin, WDR13, WDR40A, XPC, ZC3HAV1L, ZNF267, ZNF425, ZNF434, ZNF629, ZNF79, and ZNF843.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apigenin, 5 mg | sc-3529 | 5 mg | $32.00 | |||
Apigenin, 100 mg | sc-3529A | 100 mg | $210.00 | |||
Apigenin, 1 g | sc-3529B | 1 g | $720.00 | |||
Apigenin, 5 g | sc-3529C | 5 g | $1128.00 | |||
Apigenin, 25 g | sc-3529D | 25 g | $2302.00 | |||
Apigenin, 100 g | sc-3529E | 100 g | $3066.00 | |||
Apigenin, 1 kg | sc-3529F | 1 kg | $5106.00 |