RNF20 Inhibitors
RNF20 Inhibitors constitute a chemical class developed to interact with and modulate the activity of the RNF20 protein. RNF20, also known as E3 ubiquitin-protein ligase BRE1A, functions as an enzyme critical in the monoubiquitination of histone H2B, a key post-translational modification governing chromatin structure and gene regulation. Inhibitors specific to RNF20 are engineered to interfere with or regulate its catalytic activity, thereby impacting the process of monoubiquitination on histone H2B and the ensuing chromatin modifications and transcriptional regulation associated with this essential event.
The primary mechanism of action for RNF20 inhibitors involves binding to the RNF20 enzyme, typically at its active site or specific domains crucial for histone H2B monoubiquitination. This interaction can disrupt or modulate the enzymatic activity of RNF20, thereby influencing the addition of the ubiquitin moiety to histone H2B. Consequently, these inhibitors are indispensable tools for scientists exploring the field of epigenetics, chromatin structure, and gene expression. By interfering with RNF20, researchers can unravel the intricate molecular mechanisms governing chromatin dynamics and transcriptional control, contributing to a more profound understanding of fundamental cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 indirectly inhibits RNF20 by targeting the NEDD8-activating enzyme (NAE). NAE is involved in the neddylation of proteins, including RNF20, which is required for its activity. MLN4924 inhibits NAE, leading to the inactivation of RNF20. | ||||||
PRT4165 | 31083-55-3 | sc-507487 | 10 mg | $134.00 | ||
PRT4165 is an inhibitor of the RNF20/RNF40 heterodimer, preventing their interaction and thereby reducing H2B monoubiquitination, a critical substrate of RNF20. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $52.00 | 3 | |
NSC697923 disrupts the interaction between RNF20 and its substrates, thereby inhibiting the ubiquitination activity of RNF20. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a small molecule inhibitor of the p300 histone acetyltransferase, which indirectly affects RNF20 activity by modulating histone acetylation. Changes in histone acetylation can impact the recruitment of RNF20 to specific genomic loci. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 inhibits the Wnt/β-catenin signaling pathway, which can have downstream effects on RNF20 activity in specific cellular contexts. Inhibition of Wnt/β-catenin signaling may impact RNF20-regulated gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to inhibit RNF20 expression and function in certain cancer cell lines. It can affect RNF20 activity by downregulating its expression or modulating its function. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is an HDAC inhibitor, which indirectly influences RNF20-mediated histone modifications by altering the acetylation status of histones. Changes in histone acetylation can affect RNF20-regulated gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA demethylating agent that can affect gene expression, including genes regulated by RNF20. Changes in DNA methylation can influence the accessibility of DNA to RNF20 and other regulatory proteins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA is a derivative of vitamin A that can alter gene expression patterns. This can indirectly affect RNF20 activity by modifying the expression of genes that are targets of RNF20. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor that can modulate histone acetylation, which indirectly affects RNF20-mediated histone modifications. Changes in histone acetylation can impact the regulation of genes by RNF20. | ||||||