Molecular structure of NSC697923, CAS Number: 343351-67-7
NSC697923 (CAS 343351-67-7)
See product citations (3)
Alternate Names:
2-(4-Methylphenyl)sulfonyl-5-nitrofuran
Application:
NSC697923 is a selective inhibitor of Ubc13-Uev1A
CAS Number:
343351-67-7
Purity:
≥98%
Molecular Weight:
267.3
Molecular Formula:
C11H9NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC697923 is a selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A suggested to disrupt formation of the Ubc13-Ub conjugate. Shown to inhibit proliferation and survival of certain B-cell lymphoma cells. NSC697923 falls within the nitrofuran derivatives category as a synthetic organic compound. Its physical form is that of a crystalline solid exhibiting a yellow hue, with its melting point measured at 148-150° C. The core arrangement of NSC697923 involves a sulfonyl group, a nitro group, and a methylphenyl group, all intricately linked via a five-membered furan ring.
NSC697923 (CAS 343351-67-7) References
- Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. | Pulvino, M., et al. 2012. Blood. 120: 1668-77. PMID: 22791293
- A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. | Cheng, J., et al. 2014. Cell Death Dis. 5: e1079. PMID: 24556694
- Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. | Ritorto, MS., et al. 2014. Nat Commun. 5: 4763. PMID: 25159004
- Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. | Hodge, CD., et al. 2015. ACS Chem Biol. 10: 1718-28. PMID: 25909880
- A Generic Platform for Cellular Screening Against Ubiquitin Ligases. | Maculins, T., et al. 2016. Sci Rep. 6: 18940. PMID: 26743172
- Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. | Gombodorj, N., et al. 2017. Anticancer Res. 37: 2425-2436. PMID: 28476810
- Deregulation of autophagy under hyperglycemic conditions is dependent on increased lysine 63 ubiquitination: a candidate mechanism in the progression of diabetic nephropathy. | Pontrelli, P., et al. 2018. J Mol Med (Berl). 96: 645-659. PMID: 29806072
- UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. | Dikshit, A., et al. 2018. Cancer Res. 78: 6462-6472. PMID: 30224375
- Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes. | Monda, JK. and Cheeseman, IM. 2018. Open Biol. 8: PMID: 30257893
- Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461. | Masud, T., et al. 2021. Sci Rep. 11: 9812. PMID: 33963218
- Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice. | Pontrelli, P., et al. 2021. Int J Mol Sci. 22: PMID: 34068941
- Deletion of Plasmodium falciparum ubc13 increases parasite sensitivity to the mutagen, methyl methanesulfonate and dihydroartemisinin. | Maneekesorn, S., et al. 2021. Sci Rep. 11: 21791. PMID: 34750454
- A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation. | Cao, DY., et al. 2022. Immunol Lett. 244: 28-39. PMID: 35288207
- Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses. | Boghdeh, NA., et al. 2023. Viruses. 15: PMID: 36992362
- CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade glioma. | Wenger, A., et al. 2023. Clin Epigenetics. 15: 80. PMID: 37161535
Inhibitor of:
4930444G20Rik, AOS-1, ASXL2, C12orf51, Cdc34B, CG018, DDX41, DUB1, DUB1A, DUB2, DUB2A, EG546638, FBXW24, G2E3, HERPUD2, IBRDC1, Importin-7, IRF-7, ISG15, KBTBD5, KLHL6, LOC728393, MAGE-D4, Mms2, OTUD2, OTUD7A, OTUD7B, QPCTL, RFWD3, RLIM, RNF10, RNF135, RNF138, RNF151, RNF186, RNF20, RNF215, RNF222, RNF40, Skeletrophin, TMEM129, Tollip, TRIM12, Ub, UBC13, UBE1, UBE2B, UBE2C, UBE2D4, UBE2G1, UBE2G2, UBE2H, UBE2QL1, UBE2U, UBE2Z, Ubiquitin conjugating enzyme E2 (UBE2), Ubp-M, UBXN2B, UCH-L3, Uev1A, USP18, and USP50.Activator of:
ASB-5, EG229571, NEURL1B, UBC13, USP1, USP15, USP21, USP25, USP30, USP38, and USP47.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC697923, 1 mg | sc-391107 | 1 mg | $15.00 | |||
NSC697923, 5 mg | sc-391107A | 5 mg | $51.00 |