RAD (DNA repair) Inhibitors
The RAD protein family in humans plays a crucial role in DNA repair signaling, essential for maintaining genomic integrity and preventing mutations. RAD proteins in yeast were originally identified as radiation-sentitive gene products involved in mitotic/meiotic recombination,and mating-type switching. Key members of this family, such as RAD51, are involved in homologous recombination, a precise method of repairing double-strand breaks in DNA. RAD proteins recognize and respond to DNA damage, recruiting and coordinating with other proteins to facilitate repair. Mutations or dysfunctions in RAD genes can lead to impaired DNA repair, contributing to genomic instability and increasing the risk of cancer development. These proteins also interact with the BRCA1 and BRCA2 genes, further highlighting their importance in hereditary breast and ovarian cancers. Overall, the RAD protein family is integral to the complex and vital process of DNA repair, safeguarding cell health and preventing malignant transformation.
Targeting the RAD protein family or DNA repair pathways for disruption or inhibition has become a strategic approach in cancer therapy. By inhibiting these pathways, particularly in cancer cells that already have compromised DNA repair mechanisms, can induce synthetic lethality, where the accumulation of unrepaired DNA damage leads to cell death. This approach is especially effective in cancers with BRCA1/2 mutations, which are reliant on alternative repair pathways like those mediated by RAD proteins. Additionally, such targeting can sensitize tumors to radiation and chemotherapy, as these cause DNA damage that requires effective repair pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate RAD23A transcription by altering the activity of specific transcription factors or by changing the methylation status of the RAD23A promoter region. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has the potential to decrease RAD23A expression through the inhibition of transcription factor binding or by inducing histone modifications at the RAD23A gene locus. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could reduce RAD23A mRNA levels by inhibiting kinase enzymes that are upstream of the transcriptional machinery responsible for RAD23A gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can lead to the reduced expression of RAD23A by binding to retinoic acid receptors that interact with the RAD23A gene promoter, thereby repressing its transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide may inhibit RAD23A expression by inducing DNA strand breaks and triggering a DNA damage response that can lead to the repression of non-essential DNA repair genes, including RAD23A. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
By inhibiting thymidylate synthase, 5-Fluorouracil causes DNA damage and may lead to a decrease in RAD23A expression as part of the cellular response to genotoxic stress. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin can inhibit RAD23A protein synthesis by directly inhibiting the mTOR pathway, which is critical for cap-dependent translation initiation of many mRNAs, including RAD23A. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin can downregulate RAD23A expression through DNA intercalation and inhibition of topoisomerase II, which can prompt a reduction in the transcription of certain repair genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate can decrease RAD23A expression by inhibiting histone deacetylases, which increases acetylation of histones and alters the expression of specific genes including RAD23A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 may lead to the reduced expression of RAD23A by inhibiting PI3K, thereby obstructing the AKT signaling pathway that is involved in the transcription of RAD23A. | ||||||