Rac 2 Activators
Rac2 activators belong to a class of chemical compounds designed to specifically target and modulate the activity of Rac2, a member of the Rho GTPase family of proteins. Rac2 is primarily associated with regulating various cellular processes, particularly those related to cytoskeletal dynamics, cell motility, and cell adhesion. This protein is involved in signal transduction pathways that control actin polymerization and rearrangement, which are essential for processes like cell migration, phagocytosis, and the formation of lamellipodia and filopodia. Rac2, like other GTPases, cycles between an active, GTP-bound state and an inactive, GDP-bound state, and its activation is tightly regulated in response to extracellular cues.
Rac2 activators are designed to promote the activation of Rac2 by facilitating its binding to GTP, which in turn stimulates downstream signaling cascades leading to cellular responses. By modulating Rac2 activity, these compounds have the ability to influence the organization of the actin cytoskeleton, cell shape, and the overall motility and adhesion of cells. Understanding the mechanisms and effects of Rac2 activators is of significant interest in cell biology and molecular research, as it can shed light on the intricate regulatory networks governing cell movement and adhesion. These compounds serve as valuable tools for dissecting the roles of Rac2 in cellular processes and exploring its involvement in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A might influence Rac2 expression by inhibiting calcineurin, thereby affecting T-cell activation and related signaling pathways, which can indirectly impact gene expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine could potentially modulate Rac2 expression by inhibiting protein kinases, affecting multiple signaling pathways that are integral to cellular processes and gene regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, might alter Rac2 expression by affecting PI3K/Akt signaling pathway, which is involved in a wide range of cellular functions including gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may induce Rac2 expression by inhibiting mTOR, a central regulator of cell growth and metabolism, potentially impacting pathways that regulate protein synthesis and gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 could modulate Rac2 expression by inhibiting p38 MAP kinase, affecting cellular responses to stress and cytokines, which might influence gene expression patterns including Rac2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, might affect Rac2 expression by altering DNA methylation and thus modulating gene expression, which can impact various cellular processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may influence Rac2 expression by inhibiting histone deacetylases, leading to changes in chromatin structure and gene expression, potentially affecting proteins involved in cell signaling. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo, a Wnt pathway inhibitor, could potentially affect Rac2 expression by modulating Wnt signaling, a pathway important in cell proliferation, differentiation, and gene expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib might modulate Rac2 expression by inhibiting proteasome activity, thereby affecting various cellular signaling pathways and gene regulation mechanisms. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK inhibitor, could influence Rac2 expression by affecting cytoskeleton dynamics and related signaling pathways, which might indirectly impact gene expression. | ||||||