Rac 2 Inhibitors
Rac2 inhibitors belong to a class of chemical compounds designed to specifically target and modulate the activity of Rac2, a member of the Rho family of GTPases. Rac2 is a small GTPase protein that plays a crucial role in regulating various cellular processes, primarily those related to cytoskeletal dynamics and cell migration. These processes are essential for a wide range of physiological functions, including immune response, cell adhesion, and cell motility. Rac2, in particular, is predominantly expressed in hematopoietic cells, such as neutrophils, where it controls actin polymerization, superoxide production, and phagocytosis.
Rac2 inhibitors typically work by interfering with the activation and signaling pathways of Rac2, ultimately leading to the inhibition of downstream cellular processes that rely on Rac2 activity. These inhibitors often target the guanosine triphosphate (GTP)-binding site of Rac2, preventing its activation by exchanging GDP for GTP. By inhibiting Rac2, these compounds modulate immune responses and other cellular functions, making them valuable tools for research in understanding the underlying mechanisms of cell migration, inflammation, and other related processes. Additionally, Rac2 inhibitors have shown promise in studies for their applications in various diseases and conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016 selectively inhibits Rac1 and Rac2, impairing their ability to bind to downstream effectors. This results in disrupted cell signaling and cytoskeletal reorganization, possibly reducing Rac2 expression or activity. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
AZA1 selectively targets Rac1 and Rac2, hindering their GTP-binding and GTPase activity. This interruption in Rac2's function could lead to diminished cellular responses, potentially impacting its expression or activity levels. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a potent and selective inhibitor of Cdc42, with potential cross-reactivity to Rac2. By inhibiting Cdc42, cellular processes involving Rac2 might also be affected, potentially resulting in altered expression or activity of Rac2. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 disrupts the interaction between Cdc42/Rac1 and their downstream effectors. Given Rac2's similarities with Rac1, this compound might also affect Rac2, potentially influencing its expression or activity within cells. | ||||||
IPI-504 | 857402-63-2 | sc-364512 sc-364512A | 10 mg 50 mg | $640.00 $1600.00 | ||
IPI-504, also known as retaspimycin, is a heat shock protein 90 (HSP90) inhibitor. By inhibiting HSP90, it may affect the stability and function of its client proteins, including Rac2, potentially leading to reduced expression or activity of Rac2. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
IPA-3 is a selective allosteric inhibitor of PAK (p21-activated kinases), which are downstream effectors of Rac2. Inhibiting PAK could disrupt Rac2-mediated signaling pathways, potentially affecting Rac2 expression or activity. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a Rac family GTPase inhibitor, potentially affecting Rac1, Rac2, and Rac3. By inhibiting Rac2's GTPase activity, it might impact various cellular processes regulated by Rac2, potentially leading to altered expression or activity levels. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of formin homology 2 domains, which play a role in actin assembly. By inhibiting these domains, it could disrupt actin dynamics and processes regulated by Rac2, potentially leading to changes in Rac2 expression or activity. | ||||||