Molecular structure of IPA 3, CAS Number: 42521-82-4
IPA 3 (CAS 42521-82-4)
See product citations (6)
Alternate Names:
1,1′-Dithiodi-2-naphthol
Application:
IPA 3 is a group I p21-activated kinase (PAK) inhibitor
CAS Number:
42521-82-4
Molecular Weight:
350.45
Molecular Formula:
C20H14O2S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
IPA 3 is a selective cell permeable alpha PAK (Pak1, group I p21-activated kinase) inhibitor which functions by inhibiting activators from binding to the active sites on the enzyme. alpha PAK contains autoinhibitory regions that suppress the catalytic activity of its kinase domain, which are removed once activators have bound to the protein. In addition, IPA 3 does not inhibit alpha PAK if activators are already bound to the enzyme. Furthermore, IPA 3 can inhibit the activity of alpha PAK isomers that are structurally similar by autoinhibition. It is a potential antitumor agent.
IPA 3 (CAS 42521-82-4) References
- PAK'n it in: identification of a selective PAK inhibitor. | Bokoch, GM. 2008. Chem Biol. 15: 305-6. PMID: 18420134
- An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. | Deacon, SW., et al. 2008. Chem Biol. 15: 322-31. PMID: 18420139
- Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex. | Takahashi, K. and Suzuki, K. 2009. Cell Signal. 21: 695-703. PMID: 19162178
- IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. | Wong, LL., et al. 2013. PLoS One. 8: e68843. PMID: 23894351
- Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice. | Ji, X., et al. 2014. Brain Res. 1585: 13-22. PMID: 25148711
- Inhibition of p21-Activated Kinase 1 by IPA-3 Promotes Locomotor Recovery After Spinal Cord Injury in Mice. | Ji, X., et al. 2016. Spine (Phila Pa 1976). 41: 919-925. PMID: 26863260
- Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo. | Al-Azayzih, A., et al. 2016. Nanomedicine. 12: 1231-1239. PMID: 26949163
- PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. | Martin, K., et al. 2016. Nat Commun. 7: 12502. PMID: 27535340
- Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. | Jagadeeshan, S., et al. 2017. Cell Biol Toxicol. 33: 41-56. PMID: 27581547
- Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3-Indolepropionic Acid as an Anticolitic Agent. | Lee, H., et al. 2021. Mol Pharm. 18: 1730-1741. PMID: 33661643
- PAK1 and PAK2 in cell metabolism regulation. | Kořánová, T., et al. 2022. J Cell Biochem. 123: 375-389. PMID: 34750857
- IPA-3: An Inhibitor of Diadenylate Cyclase of Streptococcus suis with Potent Antimicrobial Activity. | Li, H., et al. 2022. Antibiotics (Basel). 11: PMID: 35326881
- Combination of PAKs inhibitors IPA-3 and PF-3758309 effectively suppresses colon carcinoma cell growth by perturbing DNA damage response. | Dukel, M. and Fiskin, K. 2023. Int J Radiat Biol. 99: 340-354. PMID: 35939342
Inhibitor of:
α-actinin-4, βPAK, γPAK, alpha PAK, ARHGAP36, ARHGAP39, ARHGAP40, ARL4D, ARL9, CCDC53, Cdc42EP2, Centaurin γ3, D6Wsu116e, Dab2, DDEF2, DDEFL1, DENND6B, FAM109A, FARP1, GBP8, Gbp9, hPAK p65, IRSp53, MSY3, ORF19, PACSIN3, PAK4, PAK5, PAK6, Pals1, PAR-6, PARD3A, PHLDB1, PIPK III, plakophilin 4, PLEKHG1, PLEKHG2, Rab 23, Rab 9B, rabphilin-11, Rac 2, RAP1GDS1, Rho C, RICS, RILPL2, TBC1D13, TOCA-1, TRIP6, WAVE3, and WDR26.Activator of:
αPIX, CapZ-α2, Cdc42EP4, CED-5, DOCK 180, ERK 5, Formin 1, FRMD6, Nek11, RICH2, SNX18, SNX20, and TC10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IPA 3, 5 mg | sc-204016 | 5 mg | $94.00 | |||
IPA 3, 50 mg | sc-204016A | 50 mg | $458.00 |