Rac 2 Antibody (3B8): sc-293429
- Rac 2 Antibody (3B8) is a mouse monoclonal IgG1 κ Rac 2 antibody provided at 100 µg/ml
- raised against amino acids 1-192 representing full length Rac 2 of human origin
- recommended for detection of Rac 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See Rac 1/2/3 (G-2): sc-514583 for Rac 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rac 2 Antibody (3B8). This work is in progress.
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Rac 2 Antibody (3B8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rac 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rac 2 antibody (3B8) is available as the non-conjugated format. Rac 2, a member of the Ras superfamily of small GTPases, plays a crucial role in regulating various cellular processes, particularly in myeloid cells where Rac 2 is predominantly expressed. Rac 2 is essential for the proper functioning of the NADPH oxidase complex in neutrophils, which is responsible for generating reactive oxygen species that are vital for the immune response against pathogens. Rac 2′s ability to interact with other proteins, such as GTPase-activating proteins (GAPs), is significant as these interactions modulate Rac 2 activity by accelerating GTP hydrolysis, thus influencing signaling pathways. Given specific expression in myeloid cells and role in immune responses, Rac 2 serves as an important target for research into immune function and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rac 2 Antibody (3B8) References:
- Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. | Knaus, UG., et al. 1991. Science. 254: 1512-5. PMID: 1660188
- Bcr encodes a GTPase-activating protein for p21rac. | Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
- Role of Ras-related C3 botulinum toxin substrate 2 (Rac2), NADPH oxidase and reactive oxygen species in diallyl disulphide-induced apoptosis of human leukaemia HL-60 cells. | Yi, L., et al. 2010. Clin Exp Pharmacol Physiol. 37: 1147-53. PMID: 20804509
- The cellular functions of small GTP-binding proteins. | Hall, A. 1990. Science. 249: 635-40. PMID: 2116664
- The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. | Xu, GF., et al. 1990. Cell. 63: 835-41. PMID: 2121369
- The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. | Martin, GA., et al. 1990. Cell. 63: 843-9. PMID: 2121370
- The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. | Ballester, R., et al. 1990. Cell. 63: 851-9. PMID: 2121371
- rac, a novel ras-related family of proteins that are botulinum toxin substrates. | Didsbury, J., et al. 1989. J Biol Chem. 264: 16378-82. PMID: 2674130
- A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. | Trahey, M. and McCormick, F. 1987. Science. 238: 542-5. PMID: 2821624
- Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. | Sewell, JL. and Kahn, RA. 1988. Proc Natl Acad Sci U S A. 85: 4620-4. PMID: 3133654
- Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development. | Zhang, J., et al. 2022. Arterioscler Thromb Vasc Biol. 42: 700-716. PMID: 35354308
- Clinical and functional spectrum of RAC2-related immunodeficiency. | Donkó, Á., et al. 2024. Blood. 143: 1476-1487. PMID: 38194689
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rac 2 Antibody (3B8) | sc-293429 | 100 µg/ml | $316.00 |