Molecular structure of IWR-1-endo, CAS Number: 1127442-82-3
IWR-1-endo (CAS 1127442-82-3)
See product citations (19)
Alternate Names:
IWR-1-endo is also known as endo-IWR 1.
Application:
IWR-1-endo is a potent inhibitor of the Wnt/β-catenin response, able to increase Axin2 protein levels without changing Apc or GSK3β levels.
CAS Number:
1127442-82-3
Purity:
≥98%
Molecular Weight:
409.44
Molecular Formula:
C25H19N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IWR-1-endo is a potent Wnt signaling inhibitor. Since Wnt protein signaling leads to β-catenin activation, IWR-1-endo then inhibits a cell-based Wnt/β-catenin pathway reporter response. Wnt-induced accumulation of β-catenin is inhibited by IWR-1-endo, and the destruction complex is stabilized as a result. When IWR-1-endo stabilizes Axin-scaffolded destruction complexes, β-catenin phosphorylation is promoted. Additionally, IWR-1-endo promotes endothelial cell specification of cardiac progenitor cells.
IWR-1-endo (CAS 1127442-82-3) References
- Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. | Kadoshima, T., et al. 2013. Proc Natl Acad Sci U S A. 110: 20284-9. PMID: 24277810
- Astaxanthin induces angiogenesis through Wnt/β-catenin signaling pathway. | Xu, Y., et al. 2015. Phytomedicine. 22: 744-51. PMID: 26141761
- Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation. | Wang, R., et al. 2015. Genet Mol Res. 14: 7315-25. PMID: 26214410
- SOST silencing promotes proliferation and invasion and reduces apoptosis of retinoblastoma cells by activating Wnt/β-catenin signaling pathway. | Wu, T., et al. 2017. Gene Ther. 24: 399-407. PMID: 28485721
- LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells. | Li, G., et al. 2017. Sci Rep. 7: 11021. PMID: 28887537
- Wnt inhibition promotes vascular specification of embryonic cardiac progenitors. | Reichman, DE., et al. 2018. Development. 145: PMID: 29217753
- Efflux inhibition by IWR-1-endo confers sensitivity to doxorubicin effects in osteosarcoma cells. | Gustafson, CT., et al. 2018. Biochem Pharmacol. 150: 141-149. PMID: 29412166
- Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/β-catenin signaling pathway. | Wang, Y., et al. 2019. Ren Fail. 41: 159-166. PMID: 30931679
- Calcitonin protects rat chondrocytes from IL-1β injury via the Wnt/β-catenin pathway. | Bai, M., et al. 2019. Exp Ther Med. 18: 2079-2085. PMID: 31452704
- Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features. | Vila-Cejudo, M., et al. 2020. J Assist Reprod Genet. 37: 2967-2979. PMID: 33047186
- aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2. | Sun, J., et al. 2021. Redox Biol. 39: 101811. PMID: 33360774
- Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells. | Ito, A., et al. 2021. Biochem Biophys Res Commun. 552: 66-72. PMID: 33743349
- rhFGF20 promotes angiogenesis and vascular repair following traumatic brain injury by regulating Wnt/β-catenin pathway. | Guo, R., et al. 2021. Biomed Pharmacother. 143: 112200. PMID: 34649342
- TEAD4 overexpression suppresses thyroid cancer progression and metastasis in vitro by modulating Wnt signaling. | Zhang, B., et al. 2022. J Biosci. 47: PMID: 34951409
- Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway. | Xu, ZH., et al. 2022. Am J Physiol Renal Physiol. 322: F611-F624. PMID: 35403451
- Inhibition of Canonical Wnt Signaling Promotes Ex Vivo Maintenance and Proliferation of Hematopoietic Stem Cells in Zebrafish. | Kimura, K., et al. 2022. Stem Cells. 40: 831-842. PMID: 35759948
- Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study. | Nair, S., et al. 2022. Molecules. 27: PMID: 36080214
Inhibitor of:
β3Gn-T5, 2610208M17Rik, 9430069J07Rik, ANKRD43, APC, APCDD1, ARMC5, Arp2, Axin, Barx2, Bcl-9, Bcl-9L, beta-catenin, BHLHA9, BMP2K, brachyury 2, C1orf80, C20orf95, C3orf34_1500031L02Rik, C6orf100, calsyntenin-1, CCDC16, CELSR3, COUP-TFI, CTNNBL1, Dapper2, EG623186, ERRβ, FHL-1, Gm14137, GPR177, Hairless, HOP-1, HOS, HoxD1, HR, Islet-2, ITF-1, Kremen-1, Kremen-2, Krox-26, LGR6, LOC100041397, LOC391358, LOC729121, LRP5L, LRRC14, LRRC44, MAB-5, mPRβ, musculin, NK homeobox (NKX), NKD1, Nkx-2.2, Nkx-3.2, Nlk, PC-LKC, PCDH11X, POPX1, Prickle4, Rho C, Rhotekin 2, Ripply1, RNF146, robo2, SHISA3, SHKBP1, SHOX, SOSTDC1, Tankyrase, Tankyrase-1, Tankyrase-2, TBX5, TBX6, TCF-1, TCF-3, TCF23, TLE2, TMEM88, TNIK, Vangl1, VRTN, WDR27, WIF-1, Wnt, Wnt-1, Wnt-14, Wnt-3, Wnt-3a, Wnt-6, WTX, Zfp866, and ZNF883.Activator of:
AIDA, BAR-1, BC061237, brachyury, CELSR1, Chibby, chordin, CHRDL1, DIXDC1, Dkk-2, FOXD4, frizzled-1, frizzled-3, FXR2, INTU, Kremen-2, LBH, LGR4, LGR5, LHX4, LIN-31, LRRC15, M-cadherin, Manic Fringe, MESDC1, MIA, MICAL3, neuropilin, Nkx-6.3, Rac 2, Reg IV, RNF43, Sox-10, Sox-7, SUSD2, tinman, TM4SF5, Vangl2, Wnt-10a, Wnt-10b, Wnt-11, Wnt-14b, Wnt-16, and WRM-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IWR-1-endo, 5 mg | sc-295215 | 5 mg | $82.00 | |||
IWR-1-endo, 10 mg | sc-295215A | 10 mg | $132.00 |