PKA IIβ reg Inhibitors
Inhibitors classified as PKA IIβ reg Inhibitors are characterized by their potential to dampen the activation of PKA, either by directly inhibiting the interaction between cAMP and the regulatory subunit or by influencing the cellular concentrations of cAMP. These inhibitors demonstrate the intricate control of PKA activity within cells, a process critical for the regulation of various physiological pathways, including metabolism, gene transcription, and cell differentiation.
The mechanisms by which these inhibitors function are diverse. Some mimic the structure of cAMP but with an inability to activate PKA, effectively competing with cAMP for binding sites on the regulatory subunits. Others inhibit the enzymes responsible for cAMP production, adenylyl cyclase, or increase the activity of phosphodiesterases, which degrade cAMP. By lowering intracellular cAMP levels, these compounds indirectly maintain PKA IIβ reg in its inactive form, coupled with the catalytic subunits.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rp-cAMPS | 151837-09-1 | sc-24010 | 1 mg | $199.00 | 37 | |
A cAMP analog that competitively inhibits cAMP binding to the PKA regulatory subunits, including IIβ reg. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
An adenylyl cyclase inhibitor that reduces the synthesis of cAMP, indirectly inhibiting PKA IIβ reg activation. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
A potent PKA inhibitor that acts by blocking the catalytic site, which can stabilize PKA IIβ reg in its inactive form. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
A selective PKA inhibitor that binds to the catalytic subunits, indirectly affecting PKA IIβ reg function. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Can activate adenosine receptors leading to the activation of Gi proteins that reduce cAMP levels, indirectly inhibiting PKA IIβ reg. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
At high concentrations, can non-specifically inhibit phosphodiesterases, but paradoxically, it may also inhibit adenylyl cyclase at the same concentrations. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Similar to caffeine, can act as a non-selective phosphodiesterase inhibitor, but may also inhibit adenylyl cyclase at higher concentrations. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Calmodulin antagonist that can inhibit adenylyl cyclase, reducing cAMP and indirectly inhibiting PKA IIβ reg. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
A phosphodiesterase inhibitor that at certain conditions can raise cAMP levels, but also inhibits adenylyl cyclase at higher concentrations. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
An antifungal agent that has been shown to inhibit adenylyl cyclase activity, thereby potentially reducing PKA IIβ reg activation. | ||||||