Molecular structure of W-7, CAS Number: 61714-27-0
W-7 (CAS 61714-27-0)
See product citations (18)
Alternate Names:
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Application:
W-7 is a CaM (calmodulin) antagonist and antiproliferative agent
CAS Number:
61714-27-0
Purity:
≥98%
Molecular Weight:
377.34
Molecular Formula:
C16H21ClN2O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
W-7 has been reported to be a CaM (calmodulin) antagonist that inhibits Ca2+/calmodulin-regulated enzyme activities. Injection of murine tails with W-7 has demonstrated this agents ability to decrease tolerance to antinociceptive effects, therefore, CaM and its dependent pathways have demonstrated the capacity to play a role in antinociceptive agent tolerance processes. This cell permeable compound has been found to inhibit proliferation of hamster ovary K1 cells. W-7 has also been noted to bind troponin C in the presence of Ca2+ and inhibit striated muscle contractions. W-7 inhibits MYLK.
W-7 (CAS 61714-27-0) References
- Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells. | Suzuki, S., et al. 2000. J Cardiovasc Pharmacol. 36: 609-16. PMID: 11065221
- Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets. | Akimoto, T., et al. 2007. J Psychiatry Neurosci. 32: 17-22. PMID: 17245470
- The effects of calcium channel blocker benidipine and calmodulin antagonist W7 on GDP-binding capacity of brown adipose tissue in mice. | Song, YM., et al. 2009. Biol Trace Elem Res. 127: 245-50. PMID: 18953505
- Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C. | Hoffman, RM. and Sykes, BD. 2009. Biochemistry. 48: 5541-52. PMID: 19419198
- Schistosoma mansoni: possible involvement of protein kinase C in linoleic acid-induced proteolytic enzyme release from cercariae. | Matsumura, K., et al. 1991. Exp Parasitol. 72: 311-20. PMID: 2015870
- The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats. | Sepehri, G., et al. 2010. Pak J Pharm Sci. 23: 170-4. PMID: 20363694
- Effect of desipramine on a glycoprotein sialyltransferase activity in C6 cultured glioma cells. | Broquet, P., et al. 1990. J Neurochem. 54: 388-94. PMID: 2299342
- Hemocytes of Pomacea canaliculata: I. Reversible aggregation induced by Ca2+. | Shozawa, A. and Suto, C. 1990. Dev Comp Immunol. 14: 175-84. PMID: 2369966
- Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells. | Masson, M., et al. 1989. J Neurochem. 52: 1645-7. PMID: 2540282
- A calmodulin antagonist (W-7) and a protein kinase C inhibitor (H-7) have no effect on atrial natriuretic peptide release induced by atrial stretch. | Ishida, A., et al. 1988. Life Sci. 42: 1659-67. PMID: 2835563
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin. | Nakadate, T., et al. 1986. Pharmacology. 32: 167-75. PMID: 3083437
- N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide(W-7), a calmodulin antagonist, also inhibits phospholipid-sensitive calcium-dependent protein kinase. | Schatzman, RC., et al. 1983. Biochim Biophys Acta. 755: 144-7. PMID: 6297609
- N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. | Hidaka, H., et al. 1981. Proc Natl Acad Sci U S A. 78: 4354-7. PMID: 6945588
- Stimulatory effect of interleukin-1 alpha on proliferation through a Ca2+/calmodulin-dependent pathway of a human thyroid carcinoma cell line, NIM 1. | Inokuchi, N., et al. 1995. Jpn J Cancer Res. 86: 670-6. PMID: 7559085
- Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus. | Uneyama, H., et al. 1993. J Neurophysiol. 69: 1044-52. PMID: 8492147
Inhibitor of:
α T-catenin, β2-Syntrophin, ε-sarcoglycan, γ1-Syntrophin, 14-3-3 η, 1700067P10Rik, 1700069P05Rik, 1700071A11Rik, 1700071K01Rik, 1700072E05Rik, 1700072O05Rik, 1700074I03Rik, 1700074P13Rik, 1700080E11Rik, 1700080G18Rik, 1700080N15Rik, 1700080O16Rik, 1700081L11Rik, 1700084C01Rik, 1700084D21Rik, 1700084E18Rik, 1700085B13Rik, 1700086D15Rik, 1700086L19Rik, 1700088E04Rik, 1700091H14Rik, 2610528A11Rik, 4.1B, 4921537P18Rik, 4931429I11Rik, 4933412E24Rik, 4933425O20Rik, 5730419I09Rik, 6030446N20Rik, 9130409J20Rik, ACAM, ACOT11, ANKRD34C, Annexin VIII, Annexin XI, ANXA8L2, APBA2BP, apoL9b, ARA160, B230218P12Rik, Blue-Sensitive Opsin, C10orf27, C10orf95, C14orf28, C16orf47, C17orf85, C1orf158_1700012P22Rik, C1orf192, C1orf21, C2CD4D, C3orf30, C3orf39, C5orf46, C6orf105, C8orf31, C9orf93, CAB39L, CaBP1, CaBP5, CABYR, cadherin-29, Caldesmon, CALML4, CALML5, calmodulin, Calpactin, Calponin 1, calsequestrin 1, CaM, CaM II, CaM III, CaM IV, CaMK, CaMK1G, CaMKIβ, CaMKIγ, CaMKIIβ, CaMKIIγ, CaMKIIN1, cAMP-GEFII, CAMTA1, CatSperβ, CatSperγ2, CCDC102A, CCDC23, Cdhr4, CDRT15, Centrin-3, Centrin-4, CGREF1, CHERP, CIB2, claudin-9, CLP36, copine 1, copine 6, copine 7, Cypher, Cypt15, DYSFIP1, EDF1, EG331493, EG546488, EG667292, EG667485, EG667543, EGFL10, Enkurin, ERICH2, Fam148b, FAM153A, FAM183B, FAM62B, FAM62C, FAM69A, FKBP12, FLJ22184, FLJ37512, FLJ39779, FSCB, Gα s, Gα t1, gC1q-R/p32, Gliomedin, Gm1337, GPB5, Gpr165, Grancalcin, Grpa, H2-Bl, Harmonin, hnRNP UL2, Homer-1, Hrnbp3, ICA69, IdnK, IGSF4C, IQCC, ITPRIPL2, JP-45, Keg1, KIAA0247, KIAA1543, LANCL3, LIN-2, Lipocalin-L1, Lipophilin A, LOC728651, LOC730229, LR8, LRP10, LRRC20, LRRC37A3, LRRC37B, LRRIQ2, LRRTM2, LRRTM4, LYPD5, M6B, MCTP1, MCTP2, MDP-1, mGBP8, MLC, MLCKSK, MP19, MPP4, mPR, MrgB3, MRLC2, MS4A14, MS4A6D, MSY3, MYH3, MYL1, MYL10, MYL2, MYL3, MYL6, MYL6B, MYL7, Mylc2b, MYLK, MYLPF, myomesin-2, Myosin Ib, Myosin Id, Myosin VIIB, Myosin-13, Myosin-XVA, Myozenin 3, neurocalcin, neurocalcin δ, Neurotrimin, NFATc2IP, NHLRC4, NID67, Nir1, NOL7, NPR, NrCAM, Olfr1002, Olfr1020, Olfr1038, Olfr1052, Olfr1057, Olfr11, Olfr545, Olfr612, Olfr907, Olr263, OPN1MW2, OTTMUSG00000018259, OTTMUSG00000018260, PCDH18_Pcdh18, PCDHA6, PCDHA9, PCDHB14, PCDHB3, PCDHB6, PCDHBPcdhb22, Pcdhgb4, Pcdhgb8, PDZK4, PHACTR4, phospholamban, PITPα, PKA IIβ reg, PLAC8L1, PLSCR5, PMCA4, PNMA6A, PNMA6E, Popeye 2, PP2B-Aα, PRR25, PRR7, PSG2, PSG3, PSG4, PSG6, PSG7, PWP1, rabphilin-3AL, RBJ, Recoverin, RIM-BP3A, RP23-98M14.2, S-100A3, S-100Z, S-probe, SAMD9, SCRN3, Sectm1b, Shank 1, SLC35D2, SLITRK6, SLMAP, smoothelin, SMPX, Snap91, SPNS3, STAC2, STAC3, TIGD1, TM4SF19, TMCO6, TMEM107, TMEM150A, TMEM151A, TMEM151B, TMEM229B, TMEM32, TMEM35, TMEM42, TMEM66, TMTC2, TMTC3, Trak1, Tropomyosin, Troponin I-FS, Troponin I-SS, TRPC4AP, TSR3, TTC39D, TTYH2, UBN-2, UNC-79, UPIIIb, V1RA2, V1rc1, V1RC3, V1RJ2, V2R13, VILIP-2, VLP, Vmn1r100, Vmn1r103, Vmn1r117, Vmn1r119, Vmn1r121, Vmn1r124, Vmn1r128, Vmn1r143, Vmn1r168, Vmn1r224, Vmn1r92, Vmn2r11, Vmn2r114, Vmn2r17, Vmn2r26, Vmn2r31, Vmn2r42, ZCCHC10, ZDHHC18, Zfp747, ZIP9, ZNF501, ZNF658, and ZSWIM5.Activator of:
1700016D06Rik, 1700106N22Rik, ACP2, AJAP1, Amisyn, ANGEL1, ANKFN1, ANKRD20A3, ANKRD24, ANKRD30A, ANKRD46, ANKRD5, BC022651, BRDG1, BST-1, C10orf128, C10orf28, C14orf1_0610007P14Rik, C2CD4D, C9orf64, C9orf68, C9orf84, C9orf9, cadherin-20, cadherin-24, CALML4, CaMKIIN2, CaMKKα, CapZ-α2, CBWD, Ccr1l1, CD9, CLIC5, CLRN2, COPG, CRAMP1L, CT120, Desmin, DHDDS, EF-CAB3, EG668339, Endophilin II, EVI2A, FAM122A, FAM154B, FLJ10081, Fmi2, FN3KRP, G6b_AU023871, GAPVD1, Gas2L3, GATC, GLB1L, GLIPR1L2, GLT8D2, Gm13247, Gm14139, Gm14306, Gm15070, Gm5849, GMCL1L, GPR171, GPR8, GRAP1, HIP-55, HS3ST4, IBA2, IGSF3, KCTD2, Lamellipodin, LIN-2, LIPH, LOC728677, LOC729704, LSm12, Ly-49U, Lyl-1, MS4A14, MYLC2PL, MYLK, NAP125, NBEAL1, NKG2, NYD-SP18, Obscurin, OCM, Opalin, Ost, PACSIN2, PCDH7, PMCA3, QSK, RCC1, RDC-1, RICS, S-100A2, SLC-1, SLC35B4, SLC35F5, SLC7A6OS, sorcin, spectrin β I, Stereocilin, Swiprosin-2, Syntaxin 8, TBC1D3H, TBCK, TMCC2, TMEM154, TMEM161B, TMEM174, TMEM198, TMEM201, TMEM202, TMEM34, TMEM52, TMEM95, UBAP1L, VAMP-2, and YSK4.Substrate of:
Troponin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
W-7, 50 mg | sc-201501 | 50 mg | $163.00 | |||
W-7, 100 mg | sc-201501A | 100 mg | $300.00 | |||
W-7, 1 g | sc-201501B | 1 g | $1642.00 |