Molecular structure of KT 5720, CAS Number: 108068-98-0
KT 5720 (CAS 108068-98-0)
See product citations (47)
Alternate Names:
KT 5720 is also known as PROTEIN KINASE INHIBITOR KT 5720.
Application:
KT 5720 is a potent, specific and cell-permeable inhibitor of PKA, able to block PKA signaling through the competitive inhibition of ATP.
CAS Number:
108068-98-0
Purity:
≥97%
Molecular Weight:
537
Molecular Formula:
C32H31N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KT 5720 is prepared by a modificiation of K-252a (sc-200517), which is synthesized by the fungus Nocardiopsis sp. KT 5720 is a potent, specific and cell-permeable inhibitor of PKA (Ki = 56 nM) which blocks PKA signaling through the competitive inhibition of ATP. KT 5720 does not affect the activity of PKC, PKG or MLCK and can inhibit axon branching in cultured neurons. KT 5720 may act to reversibly arrest human skin fibroblasts in the G1 phase and regulate multiple signal transduction events via protein phosphorylation and cellular responses involving the cyclic AMP messenger system. KT 5720 reversed the suppression of mistletoe lectin II (MLII) by dibutyl-cyclic AMP in HL-60 cells.
KT 5720 (CAS 108068-98-0) References
- Intrahippocampal infusion of an inhibitor of protein kinase A separates short- from long-term memory. | Vianna, MR., et al. 1999. Behav Pharmacol. 10: 223-7. PMID: 10780835
- Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. Coloratum, in the human leukemic HL-60 cells. | Pae, HO., et al. 2000. Immunopharmacol Immunotoxicol. 22: 279-95. PMID: 10952032
- Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. | Huang, YY., et al. 2000. J Neurosci. 20: 6317-25. PMID: 10964936
- Specificity and mechanism of action of some commonly used protein kinase inhibitors. | Davies, SP., et al. 2000. Biochem J. 351: 95-105. PMID: 10998351
- Anti-apoptotic effects of 3,5,3'-tri-iodothyronine in mouse hepatocytes. | Sukocheva, OA. and Carpenter, DO. 2006. J Endocrinol. 191: 447-58. PMID: 17088414
- The role of protein kinase A in acute ethanol-induced neurobehavioral actions in rats. | Lai, CC., et al. 2007. Anesth Analg. 105: 89-96. PMID: 17578962
- Pharmacological PKA inhibition: all may not be what it seems. | Murray, AJ. 2008. Sci Signal. 1: re4. PMID: 18523239
- Genistein stimulates duodenal HCO(3)(-) secretion through PI3K pathway in mice. | Tuo, B., et al. 2011. Eur J Pharmacol. 651: 159-67. PMID: 21093426
- Modulation of myocardial stiffness by β-adrenergic stimulation--its role in normal and failing heart. | Falcao-Pires, I., et al. 2011. Physiol Res. 60: 599-609. PMID: 21574754
- High k(+)-induced relaxation by nitric oxide in human gastric fundus. | Kim, DH., et al. 2012. Korean J Physiol Pharmacol. 16: 297-303. PMID: 23118553
- (-)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isolated arteries. | de Siqueira, RJ., et al. 2014. Vascul Pharmacol. 63: 37-45. PMID: 25128618
- Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. | Wang, YL., et al. 2016. Biochem Biophys Res Commun. 478: 689-95. PMID: 27498007
- Terbutaline, forskolin and cAMP reduce secretion of aqueous humour in the isolated bovine eye. | Shahidullah, M., et al. 2020. PLoS One. 15: e0244253. PMID: 33347508
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. | Hidaka, H., et al. 1984. Biochemistry. 23: 5036-41. PMID: 6238627
Inhibitor of:
0610012D14Rik, 4933412E24Rik, 9130011J15Rik, A330050F15Rik, ABHD7, AKAP 100, AKAP 14, AKAP 150, AKAP 2, AKAP 220, AKAP 3, AKAP 82, Akt1, APMSF, ARPP-21, BF-1, CaM IV, CaMK1γ, CaMKIβ, cAMP-GEFII, CatSperγ2, CBF-B, CCDC23, Cdc35, CNBD2, CREB-2, CREB3L4, EG667543, Enzyme, FLJ22184, Gα 14, Gpa2, GPR178, GPSM3, LOC401317, LRRTM2, MEK, MSK1, MTH1, Neuropeptide S, NPS, Olfr101, Olfr1016, Olfr1020, Olfr1033, Olfr1036, Olfr1043, Olfr108, Olfr1086, Olfr1089, Olfr1099, Olfr11, Olfr110, Olfr1101, Olfr1105, Olfr1106, Olfr1178, Olfr1458, Olfr360, Olfr687, Olfr779, Olfr915, Olfr916, Olfr917, Olfr920, Olr22, Olr831, OR10H1, OR1D5, OR1J2, OR1L8, OR4C46, PALM2-AKAP2, PDK1, Per 2, PHK, PKA, PKA Iα reg, PKA IIα reg, PKA IIβ reg, PKAα cat, PKAβ cat, PKAγ cat, PP4R1, Protein Kinase A (PRKAR1A PRKAR1B), PRR7, RAPGEFL1, RGS22, Rim3, SC, Ser/Thr Protein Kinase, SFRS17B, SHISA6, SNAPC 19, SNAPC 45, SRY, Synapsin IIb, T2R04, T2R21, TAAR4, TAX-2, TMEM151A, UNC-13, UPIIIb, V1RA2, V1rc1, V1RC3, Vmn1r104, Vmn1r115, Vmn1r119, Vmn1r126, Vmn1r142, Vmn1r149, Vmn1r163, Vmn1r168, Vmn1r91, Vmn2r11, Vmn2r17, Vmn2r47, Vmn2r57, Vmn2r71, and VPAC2.Activator of:
BCNP1, CREB, CREST, DAF-12, H2-Db, KLHL12, KLHL34, LANCL2, MAST1, MC2-R, Olfr297, OR1A2, OR4D1, OR8S1, PALM2-AKAP2, rabphilin-3A, Ran BP-17, RGS10, RGS14, Slap, SynGAP, TIS11D, TRAM1, and Zic2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KT 5720, 50 µg | sc-3538 | 50 µg | $97.00 | |||
KT 5720, 100 µg | sc-3538A | 100 µg | $144.00 | |||
KT 5720, 500 µg | sc-3538B | 500 µg | $648.00 |