Molecular structure of Rp-cAMPS, CAS Number: 151837-09-1
Rp-cAMPS (CAS 151837-09-1)
See product citations (37)
Alternate Names:
Rp-cAMPS is also known as Rp-Cyclic AMPS.
Application:
Rp-cAMPS is a non-hydrolyzable, cell-permeable, and reversible analog of cAMP that functions as an inhibitor of PKA.
CAS Number:
151837-09-1
Purity:
>98%
Molecular Weight:
446.46
Molecular Formula:
C10H11N5O5PS•C6H16N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rp-cAMPS is a cell-permeable cAMP analogue that is resistant to hydrolysis by phosphodiesterases. It acts as a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by interacting with cAMP binding sites on the regulatory subunits (IC50=4.9 µM). The cell permeability of Rp-cAMPS and its complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. It is broadly used in cAMP-dependent signaling research, both in vitro and in vivo.
Rp-cAMPS (CAS 151837-09-1) References
- Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. | Taylor, JR., et al. 1999. J Neurosci. 19: RC23. PMID: 10479716
- Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. | Schafe, GE. and LeDoux, JE. 2000. J Neurosci. 20: RC96. PMID: 10974093
- Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement. | Liu, F., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 280: L1309-17. PMID: 11350812
- cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats. | Beninger, RJ., et al. 2003. Psychopharmacology (Berl). 170: 23-32. PMID: 12768275
- Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A. | Tronson, NC., et al. 2006. Nat Neurosci. 9: 167-9. PMID: 16415868
- Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin-permeabilized parotid acini. | Takuma, T. and Ichida, T. 1991. J Biochem. 110: 292-4. PMID: 1722200
- Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. | Anand, GS., et al. 2010. Mol Cell Proteomics. 9: 2225-37. PMID: 20167947
- Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. | Schwede, F., et al. 2015. Mol Endocrinol. 29: 988-1005. PMID: 26061564
- cAMP analog antagonists of cAMP action. | Botelho, LH., et al. 1988. Methods Enzymol. 159: 159-72. PMID: 2842582
- Hydrolysis of cyclic nucleotides by a purified cGMP-stimulated phosphodiesterase: structural requirements for hydrolysis. | Braumann, T., et al. 1986. Biochim Biophys Acta. 871: 199-206. PMID: 3011099
- Use of the cyclic AMP antagonist, Rp-cAMPS, to distinguish between cyclic AMP-dependent and cyclic AMP-independent contractile responses in rat ventricular cardiomyocytes. | Bell, D. and McDermott, BJ. 1994. J Mol Cell Cardiol. 26: 1439-48. PMID: 7897668
- Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. | Jacobson, MD., et al. 1993. Nature. 361: 365-9. PMID: 8381212
- Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. | Musgrave, IF., et al. 1993. FEBS Lett. 318: 227-30. PMID: 8382631
- Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. | Schaap, P., et al. 1993. J Biol Chem. 268: 6323-31. PMID: 8384208
- Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes. | Bois, P., et al. 1997. J Physiol. 501 (Pt 3): 565-71. PMID: 9218217
Inhibitor of:
A330050F15Rik, AKAP 100, AKAP 2, AKAP 3, AKAP 82, ARPP-21, BF-1, cAMP-GEFII, Cdc35, CREB3L4, EG667543, Odf4, Olfr360, OR1D5, PALM2-AKAP2, PKA, PKA Iα reg, PKA IIβ reg, PKAα cat, PKAγ cat, Protein Kinase A (PRKAR1A PRKAR1B), RAPGEFL1, Ser/Thr Protein Kinase, Vmn1r125, and Vmn1r91.Activator of:
AKAP 1, MPP3, and PALM2-AKAP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rp-cAMPS, 1 mg | sc-24010 | 1 mg | $203.00 |