Molecular structure of Miconazole, CAS Number: 22916-47-8
Miconazole (CAS 22916-47-8)
See product citations (2)
Alternate Names:
Monistat, Daktarin IV, Miconazolo, Miconazolum, Dactarin, Miconazol, Minostate, Brentan, Florid(nitrate)
Application:
Miconazole is an antifungal inhibitor of CYP19 (aromatase)
CAS Number:
22916-47-8
Purity:
≥97%
Molecular Weight:
416.13
Molecular Formula:
C18H14Cl4N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Miconazole is an antifungal agent with good CYP19 (aromatase) inhibitory activity. Miconazole was discovered to be an effective chemopreventive agent in a mammary cancer cell model. Miconazole works by inhibiting the synthesis of ergosterol (critical component of fungal cell membranes). It can also be used against certain species of Leishmania protozoa.
Miconazole (CAS 22916-47-8) References
- Clinical and experimental evidence on miconazole for the treatment of systemic mycoses: a review. | Symoens, J. 1977. Proc R Soc Med. 70 Suppl 1: 4-8. PMID: 122647
- Miconazole: a historical perspective. | Fothergill, AW. 2006. Expert Rev Anti Infect Ther. 4: 171-5. PMID: 16597199
- Miconazole revisited: new evidence of antifungal efficacy from laboratory and clinical trials. | Barasch, A. and Griffin, AV. 2008. Future Microbiol. 3: 265-9. PMID: 18505391
- Miconazole mucoadhesive tablet for oropharyngeal candidiasis. | Lalla, RV. and Bensadoun, RJ. 2011. Expert Rev Anti Infect Ther. 9: 13-7. PMID: 21171872
- Miconazole mucoadhesive tablets: a novel delivery system. | Vazquez, JA. and Sobel, JD. 2012. Clin Infect Dis. 54: 1480-4. PMID: 22495075
- Nano-Sized Technologies for Miconazole Skin Delivery. | Firooz, A., et al. 2016. Curr Pharm Biotechnol. 17: 524-31. PMID: 26927217
- Dermal miconazole nitrate nanocrystals - formulation development, increased antifungal efficacy & skin penetration. | Pyo, SM., et al. 2017. Int J Pharm. 531: 350-359. PMID: 28855137
- Miconazole and terbinafine induced reactive oxygen species accumulation and topical toxicity in human keratinocytes. | Lam, PL., et al. 2022. Drug Chem Toxicol. 45: 834-838. PMID: 32538189
- Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections. | Heel, RC., et al. 1980. Drugs. 19: 7-30. PMID: 6988200
- Miconazole in coccidiodomycosis. II. Therapeutic and pharmacologic studies in man. | Stevens, DA., et al. 1976. Am J Med. 60: 191-202. PMID: 766623
- Miconazole-induced fatal dysrhythmia. | Coley, KC. and Crain, JL. 1997. Pharmacotherapy. 17: 379-82. PMID: 9085333
- Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model. | Lubet, RA., et al. 1997. Int J Cancer. 72: 95-101. PMID: 9212229
- Miconazole genotoxicity in mice. | Hassan, NH. 1997. J Appl Toxicol. 17: 313-9. PMID: 9339744
Inhibitor of:
ACOX1, ACOXL, CCDC40, CLS1, CNOX, CRS1C-2, CYP19, CYP20A1, CYP26, CYP26C1, CYP27A1, CYP27C1, CYP2A12, CYP2A5, CYP2AB1, CYP2B10, CYP2B19, CYP2B23, CYP2B9, CYP2C18, Cyp2c38, Cyp2c39, Cyp2c40, Cyp2c44, Cyp2c50, Cyp2c54, Cyp2c55, Cyp2c66, Cyp2c67, Cyp2c68, Cyp2c69, Cyp2c70, CYP2C9, CYP2F1, CYP2G1, CYP2J11, CYP2J12, CYP2J13, CYP2J5, CYP2J6, CYP2J7, CYP2J8, CYP2J9, CYP2S1, CYP2T4, CYP2U1, CYP39A1, Cyp3a13, Cyp3a16, Cyp3a44, Cyp3a57, Cyp3a59, CYP46, CYP4A11, CYP4A12A, CYP4A14, CYP4A30B, CYP4AA2, CYP4AA3, CYP4F11, Cyp4f15, Cyp4f16, Cyp4f17, CYP4F22, CYP4F3, Cyp4f37, Cyp4f39, Cyp4f40, CYP4V2, CYP4X1, CYP4Z1, Cyp60, CYP8B1, DHRS7C, Enzyme, ERG25, FMO4, Gm239, LCA5, mucolipin 3, Olfr608, Olfr945, PKA IIβ reg, S100A7A, SPNS3, Ssn6, StAR, Stim2, SULT1A4, T2R8, TMEM110, Trp3, Trp5, Trp7, and UGT2A3.Activator of:
CYP51A1, CYPOR, IP3R-III, MBP-probe, MN1, Mpk1, and nephrocystin-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Miconazole, 1 g | sc-204806 | 1 g | $65.00 | |||
Miconazole, 5 g | sc-204806A | 5 g | $157.00 |