Molecular structure of H-89 dihydrochloride, CAS Number: 130964-39-5
H-89 dihydrochloride (CAS 130964-39-5)
See product citations (71)
Alternate Names:
N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide 2HCl
Application:
H-89 dihydrochloride is a potent, cell-permeable and reversible inhibitor of PKA
CAS Number:
130964-39-5
Purity:
>99%
Molecular Weight:
519.28
Molecular Formula:
C20H20BrN3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-89 Dihydrochloride is a cell-permeable, non-selective, reversible, ATP-competitive, potent inhibitor of PKA (cyclic AMP-dependent protein kinase). PKA regulates glycogen, sugar and lipid metabolism and plays an important role in the cell cycle. H-89, once thought to be a selective PKA inhibitor, may act to also inhibit CaM kinase II, casein kinase I, Rsk-2 (MAPKAP-K1b), MSK1, MYLK (myosin light chain kinase), Akt1 (PKB alpha), PKC mu, Rock-2 (ROCK-II) and p70 S6 kinase alpha.
H-89 dihydrochloride (CAS 130964-39-5) References
- Specificity and mechanism of action of some commonly used protein kinase inhibitors. | Davies, SP., et al. 2000. Biochem J. 351: 95-105. PMID: 10998351
- Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. | Li, M., et al. 2000. Mol Cell Biol. 20: 9356-63. PMID: 11094086
- Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. | Yamagishi, SI., et al. 2001. J Biol Chem. 276: 25096-100. PMID: 11342529
- Biphasic modulation of nociceptive processing by the cyclic AMP-protein kinase A signalling pathway in sheep spinal cord. | Dolan, S. and Nolan, AM. 2001. Neurosci Lett. 309: 157-60. PMID: 11514065
- Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis. | Perez, MC., et al. 2002. Fertil Steril. 77: 1261-8. PMID: 12057738
- Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. | Littlepage, LE., et al. 2002. Proc Natl Acad Sci U S A. 99: 15440-5. PMID: 12422018
- 1alpha,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells. | Menegaz, D., et al. 2010. J Steroid Biochem Mol Biol. 119: 127-34. PMID: 20156558
- Localised Ca channel phosphorylation modulates the distribution of L-type Ca current in cardiac myocytes. | Chase, A., et al. 2010. J Mol Cell Cardiol. 49: 121-31. PMID: 20188735
- Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. | Chijiwa, T., et al. 1990. J Biol Chem. 265: 5267-72. PMID: 2156866
- IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor. | El-Shazly, AE., et al. 2011. Int Immunopharmacol. 11: 1864-70. PMID: 21835268
- NF-κB and CREB are involved in IL-8 production of human neutrophils induced by Trichomonas vaginalis-derived secretory products. | Nam, YH., et al. 2011. Korean J Parasitol. 49: 291-4. PMID: 22072831
- Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor. | Liu, B. and Chen, F. 2022. Peptides. 154: 170824. PMID: 35660638
- Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. | Engh, RA., et al. 1996. J Biol Chem. 271: 26157-64. PMID: 8824261
Inhibitor of:
β2-Adaptin, ζ2-COP, 0610012D14Rik, 1110054M08Rik, 1190002F15Rik, A030009H04Rik, A230107C01Rik, ABHD5, Adrenomedullin, AI314976, AKAP 100, AKAP 2, AKAP 220, Akt1, ANKK1, ANKRD21, ANKRD46, ANKRD55, ARD1, ARHGAP10, ARPP-21, ATF-1, Bet1, BET5, BIN2, C/EBP ε, C20orf152, C2orf73, C2orf77, C2orf80, C8orf31, Calponin 1, CaM IV, CaMKIβ, CaMKKβ, cAMP, Cdc35, CHST9, Claudin (CLDN), CMYA5, CNTFRα, COPI (Coat Protein Complex I), CREB-2, CREB3L3, DBT, ephrin-A5, ESX1, FAM69C_B230399E16Rik, FANK1, FSCB, FTSJD2, GOLT1A, GPR101, GPR115, GPR123, GPR139, GPR155, GPR63, GRK 1, GRK 4, GRK 7, HIPK4_Hipk4, HM74A, KCP3, KIAA0247, LCE2A, LOC401317, LOC622554, MEF-2A, MEF-2D, MIA2, MSK1, MSK2, MST-4, MYH1, MYH2, MYL4, MYL7, Myocyte enhancer factor (MEF2), MyoD, MYPT3, NPS, Olfr101, Olfr1033, Olfr1036, Olfr1043, Olfr1178, OR1D5, p70 S6 Kinase, Pallidin, PALM2-AKAP2, PASK, PCDHGA10, PCIF1, PHKA1, PKA, PKA IIα reg, PKA IIβ reg, PKAα cat, PKAβ cat, PKAγ cat, PKC mu, pki β, POGK, Popeye 2, PP4R1, PPIH, Protein Kinase A (PRKAR1A PRKAR1B), PRRG1, PRRG2, Purβ, RAPGEFL1, RFX3, Rock-2, RPRD2, Rsk-2, RY1, S-100, Sar1, Sar1B, SEC16L, Sec24, SEC24A, Sec24B, Sec24C, Sec31A, Sec31B, Ser/Thr Protein Kinase, SFRS17B, SIK1, SLMAP, SMEK1, Smok2a, Smok2b, Smok3b, Smok3c, SMTNL1, SSTK-IP, Ste20, Synapsin IIIa, TCP11L1, TMED2, TORC3, TRAP230, TSSK 1B, TSSK 3, TSSK 4, UT-A, V-ATPase C2, Vacuolar ATPase (V-ATPase; ATP6), Vmn1r127, Vmn2r1, VPAC2, VRK3, WIBG, X11β, ZFP60, zinedin, and ZO-1.Activator of:
β3Gn-T1, 2310008H09Rik, ABHD7, ADAM23, AI314180, AKAP 14, AKIP, ALG-4, AMZ1, ANGEL2, ANKRD32, APOBEC4, ARFGAP1, ARL10, ARMCX2, BAP1, BC057170, BCNP1, BEGAIN, Bet1L, C14orf79, C16orf57, C630004H02Rik, C7, C87436, C9orf47, CaMK1G, CaMKIIα, CAMTA2, CCDC120, CCDC69, CD161, CD39L3, Cdc25A, Cdk4, CLIC5, CREB, CREST, cystatin S, DENND1B, DERP6, Dexras1, EXOSC9, FAM164A, FAM164C, FAM70A, FAM83B, FAM8A1, Fibrosin, FLJ37512, FLJ46082, FRMPD1, FRMPD3, FUZ, GPI-PLD, GPR8, GS188, HCF1, HDX, IL-5Rα, IZUMO2, KCTD2, KIR2DL3, KV4.2, LBP-9, LHFPL1, Limd1, LKB1, LOC100133301, LOC100133893, LOC100233175, LOC390937_EG232974, LOC391747, LOC728741, LOC728762, LOC729417, LRCH2, LRP10, MACROD2, MAGIX, MAP-2, MARK2, MARK3, MAST4, MFF, MXL-1, MYPT1, N4bp2l1, Neurogranin, Niban, NMS, NRADD, Nsg2, Olr1714, Olr1733, Olr437, Olr443, Olr463, Olr482, Olr484, Olr496, Olr507, Olr516, Olr526, Olr532, Olr541, Olr552, Olr556, Olr559, Olr561, OTTMUSG00000005523, OTTMUSG00000010328, p70 S6 kinase α, PAK6, PALM2-AKAP2, Paralemmin 2, Pax-4, PFTAIRE-1, PKAγ, PP2Cβ, PP2Cκ, PPP4R4, PTα, Rab 6A, Raf-1, Rap 1A, Rap 2B, RGS14, RIMBP3B, RIN3, Rit2, ROPN1L, RPS6KL1, S-100A16, SAPAP1, SBF2, SLITRK4, SLK, Smok2b, SNAP47, SON, SorCS1, SPANX-FI, Speedy C, Spi9, SPINK13, SRPK2, SSXB5, STK32A, Synapsin IIb, Synaptotagmin XVII, Syntaxin 8, taperin, TMEM205, TRIM75, TSSC4, TSSK 6, TTC6, WDR40B, ZDHHC20, Zhangfei, Zic2, ZIP-kinase, ZNF237, ZNF41, ZNF430, ZNF611, ZNF764, ZNF772, ZNF776, ZNF829, and ZNF835.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-89 dihydrochloride, 1 mg | sc-3537 | 1 mg | $92.00 | |||
H-89 dihydrochloride, 10 mg | sc-3537A | 10 mg | $182.00 |