PKA IIβ reg Activators
The class of chemicals known as PKA IIβ reg Activators comprises a range of compounds that indirectly stimulate the activity of the PKA IIβ regulatory subunit by elevating cAMP levels within the cell. These activators include both synthetic molecules and natural products that exert their effects through a variety of mechanisms, all converging on the increase of intracellular cAMP. This elevation of cAMP serves as a second messenger that binds to the regulatory subunits of PKA, including IIβ reg, leading to a conformational change that releases the catalytic subunits. Once freed, these catalytic subunits phosphorylate a wide array of cellular proteins, thus propagating the signal initiated by the increase in cAMP.
The actions of these activators are critical for the regulation of various physiological processes that PKA is involved in, such as glycogen metabolism, lipid mobilization, and gene transcription. By increasing cAMP levels, PKA IIβ reg activators ensure that PKA is available to respond to cellular signals that require a rapid and potent response. The biochemical pathways influenced by these activators are diverse, yet the ultimate consequence is the activation of PKA, which plays a central role in cellular signaling and metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylyl cyclase, increasing intracellular cAMP levels and leading to activation of PKA IIβ reg. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selectively inhibits phosphodiesterases, preventing cAMP breakdown and thus activating PKA IIβ reg. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibits phosphodiesterase 4 (PDE4), leading to increased cAMP levels and activation of PKA IIβ reg. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
A PDE3 inhibitor that can increase cAMP levels, indirectly activating PKA IIβ reg. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $95.00 | 3 | |
A cAMP analog resistant to PDE degradation that can activate PKA IIβ reg by mimicking cAMP. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
A non-selective phosphodiesterase inhibitor that raises cAMP levels, activating PKA IIβ reg. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Similar to caffeine, it inhibits phosphodiesterases, increasing cAMP concentration and activating PKA IIβ reg. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Inhibits various phosphodiesterases, leading to an increase in cAMP levels and activation of PKA IIβ reg. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
A PDE1 inhibitor that may raise cAMP levels, thereby activating PKA IIβ reg. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
A dual PDE3 and PDE4 inhibitor that increases cAMP levels, activating PKA IIβ reg. | ||||||