Molecular structure of Sp-cAMPS, CAS Number: 93602-66-5
Sp-cAMPS (CAS 93602-66-5)
See product citations (3)
Application:
Sp-cAMPS is an activator of phosphotransferase and PKA )cAMP-dependent kinase)
CAS Number:
93602-66-5
Purity:
≥98%
Molecular Weight:
446.46
Molecular Formula:
C10H11N5O5PS•C6H16N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sp-cAMPS, a stimulatory diastereoisomer of adenosine 3′,5′-(cyclic)phosphorothioate, may act to contain an axial exocyclic sulphur atom. Experiments have noted that this agent binds to holoenzymes, releases its catalytic subunit and activates phosphotransferase and PKA (cAMP-dependent protein kinase) activity. Additionally, Sp-cAMPS has demonstrated the ability to mimick glucagon-stimulated increases in the level of Ca2+ in hepatocytes.
Sp-cAMPS (CAS 93602-66-5) References
- Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. | Taylor, JR., et al. 1999. J Neurosci. 19: RC23. PMID: 10479716
- Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty. | Viola, H., et al. 2000. J Neurosci. 20: RC112. PMID: 11090612
- The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone. | Kaji, H., et al. 1992. Biochem Biophys Res Commun. 182: 1356-61. PMID: 1311571
- The activation of cAMP-dependent protein kinase is directly linked to the regulation of osteoblast proliferation (UMR-106) by parathyroid hormone. | Kano, J., et al. 1991. Biochem Biophys Res Commun. 177: 365-9. PMID: 1645960
- Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats. | Rasmussen, BA., et al. 2012. Gastroenterology. 142: 834-843.e3. PMID: 22245844
- A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. | Rothermel, JD. and Parker Botelho, LH. 1988. Biochem J. 251: 757-62. PMID: 2843164
- The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells. | Richter-Landsberg, C. and Jastorff, B. 1986. J Cell Biol. 102: 821-9. PMID: 3005337
- Hydrolysis of cyclic nucleotides by a purified cGMP-stimulated phosphodiesterase: structural requirements for hydrolysis. | Braumann, T., et al. 1986. Biochim Biophys Acta. 871: 199-206. PMID: 3011099
- A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. | Connelly, PA., et al. 1987. J Biol Chem. 262: 4324-32. PMID: 3031072
- B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. | Wortis, HH., et al. 1995. Proc Natl Acad Sci U S A. 92: 3348-52. PMID: 7536930
- Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A. | Quayle, JM., et al. 1994. J Physiol. 475: 9-13. PMID: 8189394
- Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes. | Bois, P., et al. 1997. J Physiol. 501 (Pt 3): 565-71. PMID: 9218217
- Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray. | Punch, LJ., et al. 1997. J Neurosci. 17: 8520-7. PMID: 9334424
Inhibitor of:
AKAP 2, and cAMP-GEFII.Activator of:
2310007A19Rik, 2310007B03Rik, Adducin β, AKAP 10, AKAP 12, AKAP 150, AKAP 220, AKIP, CPEB3, CREB3L1, GPB5, HA-1, KV4.2, LT-β, neurexin I, NF-M, NHEDC1, PAPST1, Pax-4, PKA, PKA IIβ reg, pki α, Ramp4, RMP, TIS11D, TPPP, and Vmn1r167.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sp-cAMPS, 1 mg | sc-201571 | 1 mg | $95.00 |