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Papaverine (CAS 58-74-2)

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Alternate Names:
Cerespan; Papanerine
Application:
Papaverine is a phosphodiesterase inhibitor
CAS Number:
58-74-2
Purity:
97%
Molecular Weight:
339.38
Molecular Formula:
C20H21NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Papaverine is a phosphodiesterase inhibitor shown to be partially selective for PDE10A. In its pure form, papaverine is typically encountered as a white or slightly yellow crystalline powder. It has a bitter taste and is soluble in water and organic solvents, facilitating its use in various research and industrial applications. The compound′s solubility properties, along with its distinct chemical structure, make it a subject of interest in the fields of organic chemistry. Papaverine′s significance extends beyond its natural occurrence; it serves as a key molecule in the synthesis of a variety of chemical derivatives and analogs. The compound itself, due to its unique chemical structure, is often used as a reference material in analytical studies, serving as a standard for the identification and quantification of similar compounds. Furthermore, papaverine′s presence in certain plant species has made it a focus of botanical and phytochemical research, where it contributes to the understanding of alkaloid biosynthesis and the metabolic pathways in plants. Studies in this area aim to elucidate how plants produce a wide range of alkaloids and the ecological roles these compounds play. Handling papaverine, like many chemical compounds, requires adherence to safety protocols to prevent unnecessary exposure. It is important for those working with papaverine in a research or industrial context to follow proper safety guidelines, including the use of personal protective equipment (PPE) and ensuring adequate ventilation in work areas.


Papaverine (CAS 58-74-2) References

  1. Sustained release of papaverine for the treatment of cerebral vasospasm: in vitro evaluation of release kinetics and biological activity.  |  Heffez, DS. and Leong, KW. 1992. J Neurosurg. 77: 783-7. PMID: 1403123
  2. Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.  |  Eroglu, M., et al. 2007. Int Urol Nephrol. 39: 137-41. PMID: 17171413
  3. Inhibition of wound contraction by papaverine: in vitro analysis with a submucosal tissue model.  |  Sasaki, S., et al. 1991. Ann Plast Surg. 27: 562-9. PMID: 1793243
  4. New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam.  |  Bihel, FJ., et al. 2011. Bioorg Med Chem Lett. 21: 6567-72. PMID: 21920746
  5. Intracavernous papaverine in the management of psychogenic impotence.  |  Dhabuwala, CB., et al. 1990. Arch Androl. 24: 185-91. PMID: 2327828
  6. Inhibitory effect of papaverine on HIV replication in vitro.  |  Turano, A., et al. 1989. AIDS Res Hum Retroviruses. 5: 183-92. PMID: 2713167
  7. Papaverine-induced fibrosis of the corpus cavernosum.  |  Fuchs, ME. and Brawer, MK. 1989. J Urol. 141: 125. PMID: 2908935
  8. Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine.  |  Klenk, JM., et al. 2019. J Biochem. 166: 51-66. PMID: 30759214
  9. Antinociceptive activity of the novel RAGE inhibitor, papaverine, in a mouse model of chronic inflammatory pain.  |  Yoshizawa, K., et al. 2021. Synapse. 75: e22188. PMID: 32979223
  10. Comparison of the Apoptotic Effects of Topically Applied Papaverine, Diltiazem, and Nitroprusside to Internal Thoracic Artery.  |  Unal, O., et al. 2020. Braz J Cardiovasc Surg. 35: 626-633. PMID: 33118726
  11. Papaverine, a promising therapeutic agent for the treatment of COVID-19 patients with underlying cardiovascular diseases (CVDs).  |  Valipour, M., et al. 2022. Drug Dev Res. 83: 1246-1250. PMID: 35706384
  12. The effect of papaverine on local tissue PO2 and microflow in cat brain cortex.  |  Nikolov, R. and Leniger-Follert, E. 1978. Naunyn Schmiedebergs Arch Pharmacol. 305: 149-54. PMID: 732890
  13. Papaverine-induced inhibition of electrical and mechanical activity and calcium movements of rat ileal smooth muscle.  |  Huddart, H. and Saad, KH. 1980. J Exp Biol. 86: 99-114. PMID: 7400753

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Papaverine, 10 mg

sc-279951
10 mg
$153.00

Papaverine, 50 mg

sc-279951A
50 mg
$265.00

Papaverine, 100 mg

sc-279951B
100 mg
$459.00