PIPK I γ Activators
Chemicals classified as PIPK I γ Activators encompass a range of compounds that can indirectly influence the activity of Phosphatidylinositol-4-phosphate 5-kinase type I gamma (PIPK I γ). This influence is exerted through the modulation of various signaling pathways and cellular processes that are integral to the functional role of PIPK I γ in the cell. These compounds do not directly activate PIPK I γ but rather affect the cellular environment or upstream signaling mechanisms, leading to changes in PIPK I γ activity.
The selection includes compounds that affect protein kinase activity, such as Phorbol 12-myristate 13-acetate (PMA) and Staurosporine, influencing pathways that can lead to changes in the phosphorylation state of molecules involved in PIPK I γ regulation. Other compounds, like Ionomycin and BAPTA-AM, alter intracellular calcium levels, which are known to play a significant role in various signaling pathways, including those that may impact PIPK I γ. Inhibitors of specific kinases or phosphatases, such as LY294002, Wortmannin, and Okadaic Acid, are included due to their to modulate phosphoinositide signaling, which is closely related to PIPK I γ activity. Additionally, compounds like Forskolin and Neomycin offer distinct mechanisms of modulating cellular signaling pathways that could, in turn, influence PIPK I γ.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C (PKC), which can lead to the phosphorylation of proteins involved in the PI signaling pathway, potentially enhancing PIPK I γ activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, which can activate calmodulin and influence the PI signaling pathway, potentially affecting PIPK I γ activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, increasing cAMP levels and potentially influencing pathways that modulate PIPK I γ activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor, may influence PI signaling and indirectly affect PIPK I γ activity by modulating downstream signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor, which can affect PI signaling pathways, potentially influencing PIPK I γ activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Chelates intracellular calcium, potentially influencing pathways that modulate PIPK I γ activity through calcium signaling. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Binds to phosphoinositides, potentially affecting their availability for PIPK I γ action. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor, which can influence signaling pathways affecting PIPK I γ. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent protein kinase inhibitor, can influence multiple signaling pathways, potentially affecting PIPK I γ activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases, potentially affecting signaling pathways involved in PIPK I γ regulation. | ||||||