PIPK I γ Antibody (H-9): sc-377061

PIPK I γ Antibody (H-9) is a mouse monoclonal IgM antibody that detects PIPK I gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PIPK I gamma antibody (H-9) is available as the non-conjugated form. The phosphatidylinositol-4-phosphate-5-kinase (PIPK) family plays a crucial role in cellular signaling by synthesizing phosphatidylinositol-4,5-bisphosphate, a key lipid that regulates various cellular processes, including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. Within this family, PIPK I γ is particularly interesting due to two variants produced by alternative splicing, which are expressed in vital organs such as the lung, brain, and kidneys. The presence of these variants suggests a nuanced role for PIPK I γ in different tissues, potentially influencing how cells respond to external signals and maintain homeostasis. Understanding the specific interactions and functions of PIPK I γ can provide insights into involvement in various physiological and pathological processes, making PIPK I gamma monoclonal antibody (H-9) an essential tool for researchers studying cellular signaling pathways and their implications in health and disease.

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PIPK I γ Antibody (H-9) References:

1. The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity.  |  Kunz, J., et al. 2000. Mol Cell. 5: 1-11. PMID: 10678164
2. Autophosphorylation of type I phosphatidylinositol phosphate kinase regulates its lipid kinase activity.  |  Itoh, T., et al. 2000. J Biol Chem. 275: 19389-94. PMID: 10777481
3. Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin.  |  Kong, X., et al. 2006. J Mol Biol. 359: 47-54. PMID: 16616931
4. Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.  |  Stadtmann, A., et al. 2015. J Immunol. 195: 1152-61. PMID: 26101325
5. Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.  |  Xu, Q., et al. 2016. Nat Commun. 7: 10777. PMID: 26916822
6. Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.  |  Li, H., et al. 2017. Oncogene. 36: 5668-5680. PMID: 28581524
7. Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.  |  Chen, C., et al. 2021. Sci Adv. 7: PMID: 34162535
8. The cloning and sequence of the C isoform of PtdIns4P 5-kinase.  |  Divecha, N., et al. 1995. Biochem J. 309 (Pt 3): 715-9. PMID: 7639683
9. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.  |  Loijens, JC. and Anderson, RA. 1996. J Biol Chem. 271: 32937-43. PMID: 8955136
10. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.  |  Ishihara, H., et al. 1998. J Biol Chem. 273: 8741-8. PMID: 9535851
11. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.  |  Tolias, KF., et al. 1998. J Biol Chem. 273: 18040-6. PMID: 9660759
12. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.  |  Rao, VD., et al. 1998. Cell. 94: 829-39. PMID: 9753329

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PIPK I γ Antibody (H-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-PIPK I γ Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PIPK I γ Antibody (H-9) Specifications

Alternate Product Name: PIPK I γ

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 633-661

Epitope Target: PIPK I γ

Epitope Species: mouse

Product Reactivity/Detection: PIPK I γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PIPK I γ Antibody (H-9): P: Blocking Peptide