Neomycin sulfateCAS: 1405-10-3
MF: C23H46N6O13•3H2SO4
MW: 908.88
A highly active antibiotic against gram-negative bacteria often used in cell culture.

Neomycin sulfate (CAS 1405-10-3)

Neomycin sulfate | CAS 1405-10-3 is rated 5.0 out of 5 by 5.
  • y_2019, m_12, d_13, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_5
  • loc_en_US, sid_3573, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
5
5
4
0
3
0
2
0
1
0
Synonym: Neomycin B sulfate
Application: A highly active antibiotic against gram-negative bacteria often used in cell culture
CAS Number: 1405-10-3
Molecular Weight: 908.88
Molecular Formula: C23H46N6O133H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.


References

1. Griffin, H.D., et al. 1980. J. Neurochem. 34: 750-752. PMID: 6243700
2. Carney, D.H., et al. 1985. Cell. 42: 479-488. PMID: 2992800
3. Vergara, J., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 6352-6356. PMID: 2994073
4. Nakashima, S., et al. 1987. Biochem. Biophys. Res. Commun. 146: 820-826. PMID: 3113426
5. Gabev, E., et al. 1989. Biochim. Biophys. Acta. 979: 105-112. PMID: 2537103
6. Liscovitch, M., et al. 1991. Biochem. J. 279: 319-321. PMID: 1930152
7. Woegerbauer, M., et al. 2000. J. Antibiot. 53: 276-285. PMID: 10819299

Formulation :
85% Neomycin B remainder Neomycin C
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ethanol (0.10 mg/ml), methanol (0.23 mg/ml), isopropanol (0.08 mg/ml), isoamyl alcohol (0.25 mg/ml), and benzene (0.05 mg/ml). Insoluble in acetone, chloroform, and ether.
Storage :
Store at 4° C
IC50 :
phospholipase C (PLC): IC50 = 1-10 µM; phosphatidylcholine-phospholipase D: IC50 = 65 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QP4375000
PubChem CID :
44134844
Merck Index :
14: 6454
MDL Number :
MFCD00077833
EC Number :
215-773-1
SMILES :
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Neomycin sulfate  Product Citations

See how others have used Neomycin sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 25329052  Kim, TJ. et al. 2014. PLoS ONE. 9: e109378.

PMID: # 16461372  Matthew C. Petersen et al. 2006. Am J Physiol Heart Circ Physiol. 291: H114-H120.

PMID: # 16920925  Palmer, G. et al. 2006. J. Immunol. 177: 2899-2907.

PMID: # 16461372  Matthew C. Petersen et al. 2006. Am J Physiol Heart Circ Physiol . 291: H114-H120.

PMID: # 16920925  Palmer, G. et al. 2006. J. Immunol. 177: 2899-2907.

PMID: # 15992890  Youssif, M. et al. 2005. Urology. 66: 201-207.

PMID: # 15611074  Yagishita, N. et al. 2005. J. Biol. Chem. 280: 7909-7916.

PMID: # 16314502  Penkov, D. et al. 2005. Mol. Cell. Biol. 25: 10768-10781.

PMID: # 16037393  O'Keeffe, M. et al. 2005. Blood. 106: 3457-3464.

PMID: # 12939287  Gingras, ME. et al. 2003. Invest. Ophthalmol. Vis. Sci. 44: 3742-3755.

Citations 1 to 10 of 16 total

Is product sc-3573 gamma irradiated?

Asked by: D2l16s00
Thank you for your inquiry. No, our Neomycin sulfate sc-3573 is not gamma irradiated.
Answered by: Technical Service
Date published: 2016-12-17
  • y_2019, m_12, d_13, h_12CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_3573, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 45ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Great features! Always work nice for our cell culture and it is worth buying.
Date published: 2018-10-19
Rated 5 out of 5 by from Excellent features We bought this reagent and used it for our routine cell culture. Worked nicely as the products from other vendors.
Date published: 2018-09-11
Rated 5 out of 5 by from excellent biochemicals We bought this chemical a month ago and it worked nicely for the cell culture.
Date published: 2018-05-27
Rated 5 out of 5 by from Great features! We bought this a month ago and it works nicely in cell culture.
Date published: 2018-05-25
Rated 5 out of 5 by from Petersen Petersen, et. al. (PubMed ID 16461372) used product sc-3573 as an antibiotic for plasma samples obtained from carotid arterial blood. -SCBT Publication Review
Date published: 2015-02-10
  • y_2019, m_12, d_13, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_5
  • loc_en_US, sid_3573, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 55ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.