PIASy Activators
PIASy activators, as listed, are primarily chemicals that indirectly affect PIASy activity by targeting pathways related to SUMOylation, transcriptional regulation, or intracellular signaling. PIASy functions as a SUMO E3 ligase and plays a role in modulating the activity of various transcription factors and signaling proteins. The chemicals mentioned, such as histone acetyltransferase inhibitors (Anacardic Acid, Ginkgolic Acid), proteasome inhibitors (MG132, Lactacystin), and signaling pathway modulators (Withaferin A, Curcumin, Resveratrol), act on different aspects of cellular regulation, influencing the function of PIASy.
These activators are significant in understanding the complex mechanisms of protein modification (like SUMOylation) and their role in regulating cellular processes. For example, proteasome inhibitors can affect the turnover of SUMOylated proteins, influencing the regulatory landscape where PIASy is active. Similarly, compounds affecting transcription factor activities or signaling pathways can modulate the processes in which PIASy is involved, given its role in transcriptional regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
Ginkgolic Acid, similar to Anacardic Acid, inhibits histone acetyltransferases, potentially impacting transcriptional activities regulated by PIASy. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits proteasomes, potentially influencing protein degradation pathways and indirectly affecting PIASy-mediated SUMOylation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin, another proteasome inhibitor, could alter the dynamics of protein turnover, indirectly influencing PIASy's role. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A inhibits NF-kappaB activation, which could indirectly affect transcriptional regulation involving PIASy. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, potentially affecting transcriptional processes where PIASy is involved. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences multiple signaling pathways, including those involved in transcriptional regulation, potentially impacting PIASy. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium Salicylate can inhibit NF-kappaB, potentially affecting transcriptional events and PIASy-mediated regulatory processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, potentially influencing signaling pathways that intersect with PIASy's regulatory roles. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, affecting intracellular signaling that could intersect with the SUMOylation processes involving PIASy. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially impacting signaling pathways and transcriptional regulation involving PIASy. | ||||||