(−)Epicatechin (CAS 490-46-0)
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(−)Epicatechin is a flavonoid compound that functions as a potent antioxidant. It interacts with cellular components by scavenging free radicals and preventing oxidative damage to cellular structures such as proteins, lipids, and DNA. This is achieved through its ability to donate hydrogen atoms to free radicals, thereby neutralizing their reactivity and preventing them from causing cellular damage. (−)Epicatechin modulates various cellular signaling pathways, including those involved in inflammation and cell survival. It can influence the activity of enzymes involved in cellular processes, such as those responsible for the metabolism of carbohydrates and lipids. (−)Epicatechin interacts with cell membrane receptors, influencing their function and downstream signaling. (−)Epicatechin plays a role in maintaining cellular health by protecting against oxidative stress and modulating cellular signaling pathways.
(−)Epicatechin (CAS 490-46-0) References
- Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signaling. | Fraga, CG. and Oteiza, PI. 2011. Free Radic Biol Med. 51: 813-23. PMID: 21699974
- Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. | Shay, J., et al. 2015. Oxid Med Cell Longev. 2015: 181260. PMID: 26180580
- (-)-Epicatechin-induced relaxation of isolated human saphenous vein: Roles of K+ and Ca2+ channels. | Marinko, M., et al. 2018. Phytother Res. 32: 267-275. PMID: 29193528
- Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm. | Fraga, CG., et al. 2018. Mol Aspects Med. 61: 31-40. PMID: 29421170
- The chemical reactivity of (-)-epicatechin quinone mainly resides in its B-ring. | Zhang, M., et al. 2018. Free Radic Biol Med. 124: 31-39. PMID: 29859347
- Effects of (-)-epicatechin on mitochondria. | Daussin, FN., et al. 2021. Nutr Rev. 79: 25-41. PMID: 32989466
- Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation. | Yan, F., et al. 2021. Biosci Rep. 41: PMID: 33521822
- ( -)-Epicatechin and cardiometabolic risk factors: a focus on potential mechanisms of action. | Hid, EJ., et al. 2022. Pflugers Arch. 474: 99-115. PMID: 34812946
- (-)-Epicatechin Improves Vasoreactivity and Mitochondrial Respiration in Thermoneutral-Housed Wistar Rat Vasculature. | Chun, JH., et al. 2022. Nutrients. 14: PMID: 35268072
- (-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage. | Ramírez-Ramírez, M., et al. 2022. J Nutr Biochem. 107: 109069. PMID: 35609849
- (-)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy. | Ling, J., et al. 2022. Oxid Med Cell Longev. 2022: 2657713. PMID: 35656027
- Identification of (-)-epicatechin metabolites and their metabolic fate in the rat. | Okushio, K., et al. 1999. Drug Metab Dispos. 27: 309-16. PMID: 9929521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)Epicatechin, 1 mg | sc-205672 | 1 mg | $50.00 | |||
(−)Epicatechin, 5 mg | sc-205672A | 5 mg | $135.00 |