PI 3-kinase p110β Activators
PI 3-kinase p110β Activators are a class of chemical compounds that exert their effects on a specific enzyme known as phosphoinositide 3-kinase (PI 3-kinase or PI3K). Specifically, they target the isoform p110β of PI 3-kinase. PI 3-kinases are a family of enzymes crucial for regulating various cellular processes, including cell growth, proliferation, survival, and metabolism. These enzymes are involved in the phosphorylation of inositol lipids, ultimately leading to the activation of downstream signaling pathways. PI 3-kinase p110β is one of the four isoforms of PI 3-kinase and is primarily associated with intracellular signaling related to growth factor receptors, G protein-coupled receptors, and other stimuli.
PI 3-kinase p110β Activators work by enhancing the catalytic activity of the p110β isoform of PI 3-kinase, leading to increased production of phosphoinositide-3,4,5-trisphosphate (PIP3) molecules. Elevated PIP3 levels play a crucial role in the recruitment and activation of downstream effector proteins like Akt, leading to the initiation of various cellular responses. These activators are valuable tools in laboratory research to dissect the specific functions and signaling pathways regulated by PI 3-kinase p110β. By manipulating the activity of this isoform, scientists can gain insights into the molecular mechanisms underlying cellular processes and potentially identify new drug targets.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in various plants, including grapes. It is known to activate several cellular pathways associated with longevity and stress resistance. Studies suggest that resveratrol may influence the PI3K/AKT pathway, potentially leading to an increase in PI 3-kinase p110β expression as part of its broader effects on cell survival and metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a bright yellow chemical produced by Curcuma longa plants. It has diverse biological activities and has been shown to interact with various signaling pathways. Research indicates that curcumin may modulate the PI3K/AKT pathway, potentially affecting the expression or activity of PI 3-kinase p110β. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains. Quercetin has been studied for its potential antioxidant and anti-inflammatory effects, and it may also influence PI3K/AKT signaling, potentially impacting PI 3-kinase p110β expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin is a biguanide used as an agent in research for type 2 diabetes. While its main action is to decrease glucose production in the liver, metformin has been shown to have several effects on cellular metabolism and signaling pathways, potentially including an influence on PI 3-kinase p110β expression through modulation of the AMPK and PI3K/AKT pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a macrolide compound used to coat coronary stents, prevent organ transplant rejection, and treat a rare lung disease called lymphangioleiomyomatosis. It has a broad impact on cellular growth and metabolism and has been shown to inhibit the mTOR pathway, a downstream target of PI3K signaling. This suggests that rapamycin might have indirect effects on PI 3-kinase p110β expression or activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays critical roles in cell growth, differentiation, and embryonic development. It has been shown to modulate various signaling pathways, potentially including PI3K/AKT, which might lead to changes in PI 3-kinase p110β expression as part of its broad effects on cellular function. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $51.00 $138.00 | ||
Epicatechin is a flavonoid present in dark chocolate, green tea, and various fruits. It has antioxidant properties and has been studied for its potential cardiovascular benefits. Epicatechin may influence PI3K/AKT signaling, potentially affecting PI 3-kinase p110β expression as part of its biological activities. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is the active component in chili peppers, responsible for their spiciness. It binds to a receptor in the pain pathway, creating a warming sensation when consumed. Studies suggest that capsaicin might have various biological effects, including the potential modulation of PI3K/AKT signaling, which could influence PI 3-kinase p110β expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a compound found in several plants such as Goldenseal, Barberry, and Oregon grape. It has diverse effects and has been studied for its potential to modulate various cellular pathways. There is evidence suggesting that berberine may influence the PI3K/AKT pathway, potentially impacting the expression or activity of PI 3-kinase p110β. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a central nervous system stimulant of the methylxanthine class. Caffeine also has been shown to modulate various cellular signaling pathways, potentially including PI3K/AKT, which might influence PI 3-kinase p110β expression or activity. | ||||||