Molecular structure of 1,1-Dimethylbiguanide, Hydrochloride, CAS Number: 1115-70-4
1,1-Dimethylbiguanide, Hydrochloride (CAS 1115-70-4)
See product citations (37)
Alternate Names:
1,1-Dimethylbiguanide, Hydrochloride is also known as Metformin Hydrochloride.
Application:
1,1-Dimethylbiguanide, Hydrochloride is a antihyperglycemic biguanide with diverse biological activities, including the stimulation of AMPK.
CAS Number:
1115-70-4
Purity:
≥99%
Molecular Weight:
165.62
Molecular Formula:
C4H11N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,1-Dimethylbiguanide, Hydrochloride is widely utilized in biochemical and physiological research for its role in modulating metabolic pathways. This compound is particularly valuable for studies focused on the mechanisms of enzyme action within cellular energy processes. Research involving 1,1-Dimethylbiguanide, Hydrochloride typically examines its effects on mitochondrial activities and its influence on AMP-activated protein kinase (AMPK), a critical regulator of cellular energy homeostasis. Additionally, the compound is used to investigate how alterations in metabolic signaling can impact cell growth and survival. Furthermore, studies with 1,1-Dimethylbiguanide, Hydrochloride explore its role in influencing glucose utilization and lipid metabolism, providing insights into cellular responses to varying energy demands.
1,1-Dimethylbiguanide, Hydrochloride (CAS 1115-70-4) References
- Metformin reverses fatty liver disease in obese, leptin-deficient mice. | Lin, HZ., et al. 2000. Nat Med. 6: 998-1003. PMID: 10973319
- Role of AMP-activated protein kinase in mechanism of metformin action. | Zhou, G., et al. 2001. J Clin Invest. 108: 1167-74. PMID: 11602624
- Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes. | Klein, J., et al. 2004. J Endocrinol. 183: 299-307. PMID: 15531718
- Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. | Cleasby, ME., et al. 2004. Diabetes. 53: 3258-66. PMID: 15561958
- In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats. | Mohiuddin, M., et al. 2009. Pak J Biol Sci. 12: 734-7. PMID: 19634481
- Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation. | Kim, HG., et al. 2011. Br J Pharmacol. 162: 1096-108. PMID: 21054339
- Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations. | Rossetti, L., et al. 1990. Metabolism. 39: 425-35. PMID: 2157941
- Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin? | Ibarra-Drendall, C., et al. 2011. Curr Breast Cancer Rep. 3: 142-150. PMID: 21949568
- Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. | Wahdan-Alaswad, RS., et al. 2014. Horm Cancer. 5: 374-89. PMID: 25213330
- Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma. | Zhou, G., et al. 2016. Curr Mol Med. 16: 83-90. PMID: 26695692
- Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells. | Xie, W., et al. 2017. Med Sci Monit. 23: 29-37. PMID: 28045889
- The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. | Bang, E., et al. 2018. Exp Neurobiol. 27: 45-56. PMID: 29535569
- Metformin decreases the high plasminogen activator inhibition capacity, plasma insulin and triglyceride levels in non-diabetic obese subjects. | Vague, P., et al. 1987. Thromb Haemost. 57: 326-8. PMID: 3310318
- Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity. | Dahmani, Z., et al. 2020. PLoS One. 15: e0240982. PMID: 33108409
- The antidiabetic drug metformin elevates receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate mass in Xenopus oocytes. | Stith, BJ., et al. 1996. Endocrinology. 137: 2990-9. PMID: 8770923
Inhibitor of:
αB-crystallin, ACAA1, ACSM2A, ACSM5, AdipoR1, ADPN, ANT3, AP-2α, ASGPR1, C/EBP α, C17orf64, C1orf163, cHMGCS, CIDE-B, Cstad, CtBP2, CUG-BP1, D10Wsu102e, DHRS13, DNTTIP2, ECHDC2, eIF4E, ENSA, FAS-L, FN3KRP, FNDC3B, FOXO6, GABP-α, GADD 153, GIP, Glut4, glycogen synthase 1, GPATCH4, GPR119, HIBCH, HIGD1B, HMGCL, I-FABP, IGFBP1, IKAP, JAM-A, Lamin B1, Laminin α-1, Laminin α-2, Laminin γ-2, LIN-28, LIN-28B, Lipin-1, Lipocalin-8, LKB1, LOC100041076, LOC100041465, LOC402377, LOC727804, LOC728200, LOC730104, LYRM1, LYVE-1, MCT4, MFF, MFG-E8, MLYCD, MORG1, MTMR12, Mts1, NALP1, NDUFAF7, NDUFB10, NDUFB3, NNMT, Norpeg, NRF-1, Olfr987, Oma1, OPN, PDZK1, PHYHIPL, PIG-W, PKD2, PKLR, Prohibitin 2, PTBP-2, RORα, RORβ, SCD5, SDR42E1, SIK1, SIK2, SIMP, SKIP, Skp2 p45, SLC7A6OS, SNAT2, Sprouty 1, SREBP-1, STC1, Syntaphilin, Tβ-4, Talin-2, TBX3, TIGAR, TR4, transgelin, TRB-3, TSC-22 D2, TUSC1, uMtCK, UPII, UPIII, VDUP1, VLDLR, and ZnT-8.Activator of:
β-1,4-GalNAc-T, β-ketoacyl synthase, γ-crystallin, 1200013P24Rik, 3β-HSD7, AARSD1, ABCF3, ABCG8, ABHD1, ABHD15, ABLIM2, ACAD-10, ACADS, ACBP, ACOT7, ACOXL, ACSF3, ACSL5, ACSS2, ACTR8, ACYP1, Adrenomedullin (ADM), ADSL, AKR7A4, AKR7A5, ALAS-H, ALDH4A1, ALF, ALMS1, AMDHD2, Amphiphysin II, AMPKα1, AMPKα2, AMPKβ1, AMPKβ2, AMPKγ1, AMPKγ2, Angptl4, ANKRD15, ANT2, Apg-1, APG5, apoO, APPL2, AQP9, ARHGEF10, ARL4, Aspartoacylase, ASPHD2, Atg2A, Atg3, ATP5 (Complex V; Mitochondrial ATP synthase), ATPAF2, ATPIF1, B-FABP, BCKDE1A, betaKlotho, BVES, C030010C08Rik, C10orf12, C11orf83, C14orf43, C16orf61, C16orf87_4921524J17Rik, C17orf42, C19orf47, C1orf63, C3orf60, C6orf120, C6orf167, C9orf123, C9orf43, CAB39L, CCDC75, CD2AP, CEACAM7, CENP-B, CES8, CHCHD1, CHCHD2, ChREBP, CKMT1, CLIP-170_restin, CLPTM1L, COG8, COQ2, COQ3, COX5a, COX7a2L, CPTI-L, CREB3L3, CSNK1A1L, CTRP6, CTRP7, CUL-4B, Cyp2c69, D830030K20Rik, DAF-16, DAF-18, DAF-2, Dbil5, DDX3X, DEPDC5, DEPDC6, DHRS11, DHRS13, DHRS4, DHRS7B, DNA Ligase I, DNC, DUS1L, eEF2K, EF-2, EF-CAB13, EG236749, EG329055, EG432995, eIF1B, eIF2Bγ, eIF4AII, eIF4E3, eIF4G, eIF5AL1, ELAC2, Elf-5, ENOSF1, ERAL1, ERG25, ERR beta, EXDL1, FA2H, FADS6, FAIM2, FAM122A, FAM124B, FAM134A_Fam134a, FAM173A, FAM57B, FAM58A, FAM63A, FAM83D, FASTKD1, FBP1, FGAM Synthase, Fis1, FOXRED2, FXR1, G3PP, G6f, G6PT, G9a, Gab 1, GABARAP, GABP-β2, GALK1, GARNL1, GATSL1, GATSL2, GCS-α-1, GDF-15, GFAT1, GHITM, GIGYF2, GIOT-1, GK5, GlcNAc kinase, GLT8D3, Glut2, GNPTG, GPD1L, GRB14, H6PD, HELZ, HIBCH, Hic-5, Hint2, HISPPD1, HLCS, HNF-3β, hnRNP E1, HSCARG_NMRAL1, HSDL2, HtrA2, HYI, IDH1, IDHC, IMMP1L, IMP5, IMPDH2, INMT, INSIG-2, Insulin II, IQCK, ITF-2, JMJD1A, JMJD1C, KAI 1, KAP3, KBTBD10, KCTD11, KIAA0329, KIAA0556, KLHDC4, KLHL22, KLHL36, Klotho, LARS2, LDH-AL6A, LDH-AL6B, LDHA, LDHB, Lipin-3, LIPT1, LIPT2, LOC284023, LOC284064, LOC441792, LOC644196, LOC646014, LOC728110, LPAAT-θ, LRP130, Ly-55B, LYPLA1, LYRM1, Mac-2BP, MAF1, MAP LC3α, MCCA, MCT11, MCT3, MCT7, METTL13, Mfn1, Mfn2, MFSD11, MFSD6L, MIF4GD, Misato, mitochondrial ferritin, MO25, MOBKL1B, Monoglyceride Lipase, Mpi, MRP-63, MRP-L24, MRP-L27, MRP-L35, MRP-L41, MRP-S12, MRP-S27, MRP-S34, MTP18, MTRNR2L7, mtTFA, MTUS2, MVK, Myofibroblasts, myoglobin, NANP, NBEAL1, NCB5OR, ND1, ND2, ND3, ND6, NDUFA7, nephrin, Nkx-2.5, NMES1, NMNAT-3, NMT1, NNT, Nocturnin, Nrf1, NT5C1A, NUBP1, nucleoporin p62, NUDT13, NUDT9, Nup188, O-GlcNAc transferase, OAT1, OAT3, OCTN2, Oma1, OSCP, OTTMUSG00000005304, p14 ARF/p16, p16-ARC, p57, PBEF, PCBD1, PDSS2, PEBP-4, Pendrin, PEPT1, PFK-2 car, PFKP, PGAM5, PGC-1α, PGC-1β, PGDH, PGK1, PGK2, PGM 2, PGM 2L1, PGPEP1L, PHACTR3, PHKA2, PI 3-kinase p100, PKLR, PKM2, Placental lactogen I, Plectin, PME-1, PNP2, PNPO, POLR3E, Pontin 52, PRDM16, PROT, PRPSAP2, PSAT1, PTP-H1, PTP-MEG2, Ptx3, QSK, Rab 7, RBCK1, RCCD1, REDD-2, REP-1, Rev-erbβ, Ribosomal Protein L14, Ribosomal Protein L5, RNF133, RoXaN, SBNO2, SCO2, SDHC, Sgk494, SHIP-2, SIRT3, SIRT4, SKI-1, SLC22A24, SLC25A14, SLC25A21, SLC25A35, SLC25A46, SLC35A5, SLC37A2, SLC38A7, SLC5A12, SLC5A8, SLC6A8, Slfn12L, Slfn13, Slfn14, Slfn8, Slfn9, SMC2, SNAT4, SOCS-7, SPAG7, Spartin, STAC2, STAMP2, StARD6, SUR-1, Synip, TBC1D12, TBC1D7, TECPR1, TFE3, TH, TIF1β, Tim10, TIP47, TMEM170, TMEM98, TMUB1, TMUB2, Tom20, Tom34, Transaldolase, TRAP-1, TrpRS, TSHZ2, TTBC1D12, TTC15, TTLL9, tuberin, TUG, UBXD7, UCP4, ULK1, USF-1, USMG5, USP40, VCP, VDAC2, VDAC3, WDFY3, WDR67, WIPI-2, WWOX, YSK1, ZMAT4, ZNF236, ZNRF3, and ZYG11BL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,1-Dimethylbiguanide, Hydrochloride, 10 mg | sc-202000F | 10 mg | $20.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 1 g | sc-202000 | 1 g | $30.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 5 g | sc-202000A | 5 g | $42.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 10 g | sc-202000B | 10 g | $62.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 50 g | sc-202000C | 50 g | $153.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 100 g | sc-202000D | 100 g | $255.00 | |||
1,1-Dimethylbiguanide, Hydrochloride, 250 g | sc-202000E | 250 g | $500.00 |