1,1-Dimethylbiguanide, Hydrochloride CAS: 1115-70-4
MF: C4H11N5•HCl
MW: 165.62
An antihyperglycemic biguanide which stimulates AMPK.

1,1-Dimethylbiguanide, Hydrochloride (CAS 1115-70-4)

1,1-Dimethylbiguanide, Hydrochloride | CAS 1115-70-4 is rated 5.0 out of 5 by 1.
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Synonym: Metformin hydrochloride
Application: An antihyperglycemic biguanide which stimulates AMPK
CAS Number: 1115-70-4
Purity: ≥99%
Molecular Weight: 165.62
Molecular Formula: C4H11N5•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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1,1-Dimethylbiguanide, Hydrochloride (Metformin) is a biguanide antihyperglycemic agent. Through glucose clamp investigation in rats 1,1-Dimethylbiguanide, Hydrochloride has been shown to lower blood glucose levels through improved glucose tolerance without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. The biguanide reduces the diabetic complications on the cardiovascular system and increases insulin sensitivity. The compound has been shown not to change the synthesis of either GLUT4 or GLUT1 but does stimulate the transport of GLUT1 to the plasma membrane as seen in skeletal muscles. The compound has also been observed to improve peripheral arterials through selective reduction of PAI-1 (plasminogen activator inhibitor). In Xenopus oocytes the compound has been documented to act by increasing intercellular calcium concentration in addition to elevating receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate. 1,1-Dimethylbiguanide, Hydrochloride has demonstrated the ability to induce fatty acid oxidation and to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase activity. In brown adipocytes 1,1-Dimethylbiguanide, Hydrochloride has been observed to inhibit leptin secretion via a mitogen-activated protein kinase signalling pathway.


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Appearance :
Physical State :
Solubility :
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
Storage :
Store at 4° C
Melting Point :
223-226° C (lit.)
IC50 :
Streptococcus sp. ′group A′: EC5050 = 4.08 µM; Streptokinase A: EC5050 = 5.65 µM (Streptococcus pyogenes serotype M1)
pK Values :
pKb: 12.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 5938
MDL Number :
EC Number :

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1,1-Dimethylbiguanide, Hydrochloride  Product Citations

See how others have used 1,1-Dimethylbiguanide, Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 15 total

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PMID: # 30926854  Gillespie, ZE. et al. 2019. Sci Rep. 9: 5369.

PMID: # 30809021  Ferretti, AC.|Hidalgo, F.|Tonucci, FM.|Almada, E.|Pariani, A.|Larocca, MC.|Favre, C.| et al. 2019. Sci Rep. 9: 2815.

PMID: # 29958542  Furat Rencber, S.|Kurnaz Ozbek, S.|Eraldemır, C.|Sezer, Z.|Kum, T.|Ceylan, S.|Guzel, E.| et al. 2018. J Ovarian Res. 11: 55.

PMID: # 30293696  Lai, EH.|Yang, CN.|Lin, SK.|Wang, HW.|Kok, SH.|Hong, CY.|Su, IH.|Yang, H.|Chang, JZ.| et al. 2018. J Endod. 44: 1817-1825.

PMID: # 27741557  Huang, YS. et al. 2017. Biomed. Chromatogr. 31:

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PMID: # 28050601  Akinci, B. et al. 2017. Cold Spring Harb Mol Case Stud. 3: a001339.

PMID: # 28243322  García-Castillo, V. et al. 2017. J Cancer. 8: 178-189.

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Citations 1 to 10 of 15 total
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Rated 5 out of 5 by from Fryer et al Fryer et al. (PubMed ID 11994296) used 1,1-Dimethylbiguanide, Hydrochloride (metformin hydrochloride) to activate AMPK in hepatocytes without having to increase AMP:ATP ratios. -SCBT Publication Review
Date published: 2015-03-09
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