PI 3-kinase p110β Antibody (C-8): sc-376641

PI 3-kinase p110β Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects PI 3-kinase p110 beta in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p110β (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PI 3-kinase p110 beta plays a crucial role in cellular signaling pathways, particularly in regulating cell growth, proliferation, and survival, making PI 3-kinase p110 beta a significant target for cancer research and therapeutic interventions. PI 3-kinase p110 beta is primarily located in the cytoplasm and participates in the phosphoinositide 3-kinase (PI3K) signaling pathway, which mediates various cellular responses to growth factors and hormones. Proper localization of PI 3-kinase p110 beta is vital for interacting with other signaling molecules to propagate the PI3K pathway effectively. Dysregulation of PI3K signaling can lead to various diseases, including cancer, highlighting the importance of studying PI 3-kinase p110 beta and its cellular interactions.

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PI 3-kinase p110β Antibody (C-8) References:

1. The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.  |  Hooshmand-Rad, R., et al. 2000. J Cell Sci. 113 Pt 2: 207-14. PMID: 10633072
2. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.  |  Hiles, ID., et al. 1992. Cell. 70: 419-29. PMID: 1322797
3. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.  |  Otsu, M., et al. 1991. Cell. 65: 91-104. PMID: 1707345
4. Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells.  |  An, HJ., et al. 2007. J Pathol. 212: 161-9. PMID: 17427168
5. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.  |  Skolnik, EY., et al. 1991. Cell. 65: 83-90. PMID: 1849461
6. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes.  |  Gates, A., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G764-74. PMID: 19196950
7. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.  |  Matheny, RW. and Adamo, ML. 2010. Cell Death Differ. 17: 677-88. PMID: 19834495
8. PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3.  |  Jackson, SP. and Schoenwaelder, SM. 2010. Curr Top Microbiol Immunol. 346: 203-24. PMID: 20517720
9. PI-3 kinase p110β: a therapeutic target in advanced prostate cancers.  |  Li, B., et al. 2014. Am J Clin Exp Urol. 2: 188-98. PMID: 25374921
10. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.  |  Stoyanov, B., et al. 1995. Science. 269: 690-3. PMID: 7624799
11. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.  |  Hu, P., et al. 1993. Mol Cell Biol. 13: 7677-88. PMID: 8246984
12. P110delta, a novel phosphoinositide 3-kinase in leukocytes.  |  Vanhaesebroeck, B., et al. 1997. Proc Natl Acad Sci U S A. 94: 4330-5. PMID: 9113989

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PI 3-kinase p110β Antibody (C-8) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-PI 3-kinase p110β Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PI 3-kinase p110β Antibody (C-8) Specifications

Alternate Product Name: PI3K p110 beta

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-31

Epitope Target: PI 3-kinase p110β

Epitope Species: human

Product Reactivity/Detection: PI 3-kinase p110β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for PI 3-kinase p110β Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin