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Capsaicin (CAS 404-86-4)

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Alternate Names:
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide 8-Methyl-N-vanillyl-6-nonenamide
Application:
Capsaicin is a TRPV1 receptor agonist that exhibits neuroprotective effects and reversibly inhibits platelet aggregation.
CAS Number:
404-86-4
Purity:
≥60%
Molecular Weight:
305.40
Molecular Formula:
C18H27NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Capsaicin is extensively used in research focusing on pain mechanisms and the neurobiology of nociception. It acts as an agonist for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is involved in the detection and regulation of body temperature as well as pain sensations. Studies involving capsaicin are for understanding how sensory neurons respond to heat and pain stimuli, providing insights into neural pathways of thermal perception and inflammation. Moreover, capsaicin is employed in studies that explore its effects on various signaling pathways that mediate inflammatory responses, contributing to a broader understanding of inflammation mechanisms. Additionally, research on capsaicin includes its role in desensitization phenomena, where repeated exposure to this compound leads to decreased sensitivity of the sensory neurons, an area of interest for exploring mechanisms underlying pain adaptation.


Capsaicin (CAS 404-86-4) References

  1. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages.  |  Kim, CS., et al. 2003. Cell Signal. 15: 299-306. PMID: 12531428
  2. Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.  |  Marvizón, JC., et al. 2003. Neuroscience. 118: 535-45. PMID: 12699788
  3. Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.  |  Pegorini, S., et al. 2005. Br J Pharmacol. 144: 727-35. PMID: 15678080
  4. Acidification of rat TRPV1 alters the kinetics of capsaicin responses.  |  Neelands, TR., et al. 2005. Mol Pain. 1: 28. PMID: 16191202
  5. Capsaicin receptor: TRPV1 a promiscuous TRP channel.  |  Pingle, SC., et al. 2007. Handb Exp Pharmacol. 155-71. PMID: 17217056
  6. Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain.  |  Ma, W. and Quirion, R. 2007. Expert Opin Ther Targets. 11: 307-20. PMID: 17298290
  7. Sensory neuron-specific actions of capsaicin: mechanisms and applications.  |  Bevan, S. and Szolcsányi, J. 1990. Trends Pharmacol Sci. 11: 330-3. PMID: 2203194
  8. Role of tachykinins in neurogenic inflammation.  |  Pernow, B. 1985. J Immunol. 135: 812s-815s. PMID: 2409169
  9. Application of capsaicin as a potential new therapeutic drug in human cancers.  |  Zhang, S., et al. 2020. J Clin Pharm Ther. 45: 16-28. PMID: 31545523
  10. Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities.  |  Braga Ferreira, LG., et al. 2020. Eur J Pharmacol. 887: 173356. PMID: 32763303
  11. Understanding the fate and impact of capsaicin in anaerobic co-digestion of food waste and waste activated sludge.  |  Du, M., et al. 2021. Water Res. 188: 116539. PMID: 33125995
  12. Analysis of the Ability of Capsaicin to Modulate the Human Gut Microbiota In Vitro.  |  Mahalak, KK., et al. 2022. Nutrients. 14: PMID: 35334939
  13. Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells.  |  Hacioglu, C. and Kar, F. 2023. Metab Brain Dis. 38: 393-408. PMID: 35438378
  14. Effects of single doses of capsaicin on nociceptive thresholds in the rodent.  |  Hayes, AG., et al. 1981. Neuropharmacology. 20: 505-11. PMID: 7242870

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Capsaicin, 50 mg

sc-3577
50 mg
$94.00

Capsaicin, 250 mg

sc-3577C
250 mg
$173.00

Capsaicin, 500 mg

sc-3577D
500 mg
$255.00

Capsaicin, 1 g

sc-3577A
1 g
$423.00

Hello - what is the source of this raw material (i.e. country of origin)? Thank you!

Asked by: Heather24
Thank you for your question. This may be lot-specific information. Please contact our Technical Service Department to require about a specific lot number, or information about the current lot.
Answered by: Technical Support
Date published: 2019-04-13

Is this product naturally derived or synthetic?

Asked by: 13punMA
Thank you for your question concerning our product Capsaicin (CAS# 404-86-4). The Capsaicin that we is from a natural source.
Answered by: Chemical Support 8
Date published: 2017-03-02

Would dihydrocapsaicin be removed from the capsaicin under the resolving conditions that it was purified?

Asked by: 13punMA
Thank you for the question about our product Capsaicin (CAS# 404-86-4). We do not know specifically if the product will be completely free of dihydrocapsacin.
Answered by: Chemical Support 8
Date published: 2017-03-02

What is Capsaicin derived from?

Asked by: SCchem16
This product is derived from chili peppers.
Answered by: Tech Service 4
Date published: 2020-09-18
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Rated 5 out of 5 by from LiuLiu, et. al. (PubMed ID 18553211) used capsaicin at various concentrations and time intervals to study its effect on galanin and galanin receptor 2 expression in primary cultured dorsal root ganglion neurons. -SCBT Publication Review
Date published: 2015-02-23
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Capsaicin is rated 5.0 out of 5 by 1.
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