PI 3-kinase p100 Activators

These compounds do not bind directly to PI3K but affect the enzyme's activity through various biochemical and molecular mechanisms.Wortmannin and LY294002, traditionally known as PI3K inhibitors, can cause a paradoxical transient activation of PI3K under certain conditions, possibly due to the intricate feedback mechanisms in cellular signaling networks. This phenomenon underscores the complexity of cellular signaling and the indirect effects that inhibitors can have on their target enzymes.

Resveratrol, Metformin, Berberine, and Nicotinamide Riboside work through AMPK activation, a key regulator of cellular energy homeostasis, which has downstream effects on the PI3K/Akt pathway, a critical pathway for cell survival, proliferation, and metabolism. Omega-3 Fatty Acids, such as EPA and DHA, alter membrane lipid composition, which can indirectly affect the localization and function of PI3K in the cell membrane. Antioxidants and phytochemicals like Curcumin, Quercetin, EGCG, and Sulforaphane modulate various signaling pathways, including those involving PI3K. Their actions are diverse, ranging from influencing oxidative stress responses to modulating gene expression and enzyme activities. Caffeine, a well-known stimulant, impacts several signaling pathways and might have an indirect effect on PI3K activity, although its precise mechanisms in this context are less clear.