Date published: 2025-12-24

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PI 3-kinase p100 Inhibitors

Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that play crucial roles in intracellular signaling pathways. One of the isoforms within the PI3K family is p100. Inhibitors designed to target this specific isoform would be referred to as PI 3-kinase p100 inhibitors. These inhibitors are intended to selectively bind to and inhibit the activity of the p100 isoform, which is involved in transmitting signals from cell surface receptors to various cellular processes, including cell growth and survival. The rationale behind developing PI 3-kinase p100 inhibitors lies in the importance of the PI3K signaling pathway in normal cellular functions and disease processes. By inhibiting the p100 isoform, researchers aim to modulate specific downstream signaling events, potentially influencing cellular behavior under certain conditions. Understanding the precise functions and implications of p100 inhibition requires further research and investigation.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Autophagy Inhibitor, 3-MA

5142-23-4sc-205596
sc-205596A
50 mg
500 mg
$56.00
$256.00
113
(3)

3-MA serves as a potent autophagy inhibitor by selectively targeting the PI 3-kinase pathway, specifically influencing the p100 subunit. Its mechanism involves disrupting the lipid kinase activity, leading to altered membrane dynamics and vesicle trafficking. The compound exhibits a unique interaction profile, characterized by specific steric hindrance that affects substrate accessibility. This modulation of autophagic flux provides a deeper understanding of cellular homeostasis and metabolic regulation.

Lipoteichoic acid

56411-57-5sc-507479
5 mg
$248.00
(0)

BAY 80-6946

1032568-63-0sc-503264
5 mg
$551.00
(0)

Chemical that can impact relapsed follicular lymphoma.

BKM120

944396-07-0sc-364437
sc-364437A
sc-364437B
sc-364437C
5 mg
10 mg
25 mg
50 mg
$173.00
$230.00
$275.00
$332.00
9
(0)

An investigational drug that has been studied in various cancer types.

GDC-0941

957054-30-7sc-364498
sc-364498A
5 mg
10 mg
$184.00
$195.00
2
(1)

An experimental PI3K inhibitor that has been studied in research models for advanced solid tumors.

IPI 145

1201438-56-3sc-488318
5 mg
$311.00
(0)

An investigational drug studied in research models for hematological malignancies.

CAL-101

870281-82-6sc-364453
10 mg
$189.00
4
(1)

An investigational drug studied in research models for various hematological malignancies.

TG100-115

677297-51-7sc-364634
sc-364634A
5 mg
100 mg
$245.00
$1836.00
1
(0)

An experimental PI3K inhibitor tested in research studies for cancer therapy.

BEZ235

915019-65-7sc-364429
50 mg
$207.00
8
(1)

An experimental PI3K/mTOR dual inhibitor studied in research for cancer research.

SF1126

936487-67-1sc-391584
sc-391584A
5 mg
10 mg
$719.00
$1331.00
7
(0)

An experimental PI3K inhibitor studied in cancer research models.