Molecular structure of Autophagy Inhibitor, 3-MA, CAS Number: 5142-23-4
Autophagy Inhibitor, 3-MA (CAS 5142-23-4)
See product citations (113)
Alternate Names:
Autophagy Inhibitor, 3-MA is also known as 3-methyladenine.
Application:
Autophagy Inhibitor, 3-MA is a multi-use inhibitor that inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases.
CAS Number:
5142-23-4
Purity:
≥95%
Molecular Weight:
149.15
Molecular Formula:
C6H7N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. It is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with Autophagy Inhibitor, 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 gamma. Autophagy Inhibitor, 3-MA is also known as 3-methyladenine, 3-methyladenine inhibitor, 3-MA, and 6-Amino-3-methylpurine.
Autophagy Inhibitor, 3-MA (CAS 5142-23-4) References
- Inhibition of autophagy in mitotic animal cells. | Eskelinen, EL., et al. 2002. Traffic. 3: 878-93. PMID: 12453151
- Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. | Beugnet, A., et al. 2003. Biochem J. 372: 555-66. PMID: 12611592
- 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN. | Hirosako, K., et al. 2004. Biochem Biophys Res Commun. 316: 845-52. PMID: 15033478
- Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. | Canu, N., et al. 2005. J Neurochem. 92: 1228-42. PMID: 15715672
- Paradoxical role of 3-methyladenine in pyocyanin-induced toxicity in 1321N1 astrocytoma and SH-SY5Y neuroblastoma cells. | McFarland, AJ., et al. 2013. Int J Toxicol. 32: 209-18. PMID: 23525265
- Quantum chemical and spectroscopic investigations of 3-methyladenine. | Alam, MJ. and Ahmad, S. 2014. Spectrochim Acta A Mol Biomol Spectrosc. 128: 653-64. PMID: 24704482
- Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells. | Tran, AT., et al. 2015. Eur J Nutr. 54: 265-72. PMID: 24830781
- 3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy. | Zou, Z., et al. 2014. J Drug Target. 22: 839-48. PMID: 25019701
- Effects of 3-methyladenine on isolated left atria subjected to simulated ischaemia-reperfusion. | Hermann, R., et al. 2015. Clin Exp Pharmacol Physiol. 42: 41-51. PMID: 25311855
- 3-methyladenine, an autophagic inhibitor, attenuates therapeutic effects of sirolimus on scopolamine-induced cognitive dysfunction in a rat model. | Zhu, B., et al. 2014. Int J Clin Exp Med. 7: 3327-32. PMID: 25419365
- Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells. | Pickard, RD., et al. 2015. Naunyn Schmiedebergs Arch Pharmacol. 388: 793-9. PMID: 25708950
- Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells. | Zhang, R., et al. 2015. Mol Med Rep. 12: 1727-32. PMID: 25846607
- [Protective effects of 3-methyladenine on acute lung injury caused by multiple trauma in rats]. | Liu, J., et al. 2015. Zhongguo Gu Shang. 28: 350-3. PMID: 26072619
- Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition. | Zheng, XY., et al. 2015. Graefes Arch Clin Exp Ophthalmol. 253: 2309-15. PMID: 26335535
- 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. | Caro, LH., et al. 1988. Eur J Biochem. 175: 325-9. PMID: 3402459
Inhibitor of:
γ-crystallin, 13orf18_5031414D18Rik, 1700011H14Rik, 3830417A13Rik, 4833422F24Rik, 4921506M07Rik, 4930544G11Rik, 4932412H11Rik, 5330417C22Rik, 5430411K18Rik, 8430408G22Rik, 9330182L06Rik, AATM, ADAT2, AGA, AIP2, AMBRA1, AP-180, APEH, APG7, Apoptosis, AQR, ARMC6, ASPHD1, ASTE1, Atg10, Atg12, Atg13, Atg14, Atg16, Atg16L2, Atg2A, Atg2B, Atg3, Atg4a, Atg4b, Atg4D, Atg9a, Atg9b, ATMIN, AUP1, BECN1L1, Bex5, BLOS3, BNIP-1, BNIP-2, BTG4, C11orf41_D430041D05Rik, C11orf74, C12orf44, C18orf26, C1orf58, C1q-A, C2orf48, C6orf72, C9orf72, CALCOCO1, CCDC15, CCDC151, CCZ1, CHAC2, CHMP1B, CHMP4A, CHMP4B, CLEC-16A, CLIC4, CLN3, COL12A1, cryptdin 5, CUEDC1, CUL-1, Cvt19, CXorf48, D030074E01Rik, DCAF16, DDRGK1, Dendritic Cell marker, Dengue Virus, DET1, DPEP2, DRAM2, EVA1A, EVA1B, EVA1C, FAM208A, FAM25A, FAM75A1, FAPP1, FASTKD5, FBXW28, FIG4, Fucokinase, FYCO1, GABARAP, GABARAPL1, GABARAPL2, Gm104, GMCL1L, GRAMD4, HPS-6, Hrs, INPP1, INPP5E, IP6K1, IPPK, IRGM (immunity-related GTPase family M), ITM2B, ITPK1, KBTBD13, KCTD21, KIAA0146, KIAA0226, KIAA0652, KLHDC5, KLHDC7A, KLHL32, KSHV ORF 45, LAPTM5, LCRG1, LENG8, LOC113230, LOC120824, LOC642612, LULL1, LYG1, Mac-3, Makorin-2, MAP LC3β, MAP LC3β2, MAP LC3γ, MAP-1S, MBOAT1, MTMR11, MTMR14, MTMR15, Myotubularin (MTM, MTMR), NAALADL1, NBPF6, Ndfip2, NDOR1, NEURL, Nix, NPAL3, NRBF2, NUDT16, Ob-R, OOEP, Optineurin, OTTMUSG00000011339, OTTMUSG00000011350, PABPC5, PACRG, Parkin, PBF, PCIA1, Peroxin 7, PGAM5, PI 3-kinase, PI 3-kinase C2α, PI 3-kinase p100, PI 3-kinase p110 gamma, PI 3-kinase p85α, PI 3-kinase p85β, PIG-U, PIP1, PITPNC1, Plb2, PLEKHF1, PLEKHF2, PLEKHS1, PMFBP1, PQLC1, PSM, Rab L5, RABAPTIN-5, Rabenosyn-5, RB1CC1, Ribosomal Protein L13A, RNF167, RNF183, RNF184, rolled, RSAD1, RUFY2, SAC1_Sac1, scute, Sec23IP, sentan, Septin 7, SESN3, SID-1, Slac2-b, SMCR8, SNX17, SNX33, Sorting Nexin (SNX), Spartin, SPATA18, SQSTM1-L1, Ssn6, Syntaxin 17, TBC1D14, TBC1D5, TECPR1, TECPR2, TEX264, TM9SF4, TMEM106A, TMEM135, TMEM144, TMEM14C, TMEM164, TMEM179B, TMEM212, TMEM41A, TMEM45B, TMEM49, TMEM55A, TMEM62, TMEM64, TMEM74, TNRC6C, TRIM16, TRIM17, TRIM2, TRIM34, TRIM36, TRIM38, TRIM43, TRIM44, TRIM48, TRIM49B, TRIM58, TRIM6, TRIM64C, TRIP12, Type I 5-phosphatase, UBA5, UBAP2, UBL7, UBXD1, UBXD5, UFSP2, ULK2, UPF0493, UVRAG, V5-Probe, Vacuolar Protein Sorting (VPS), VMP1, VPS26, Vps34, VPS35, VPS37, VSTM2B, WBSCR17, WDFY1, WDFY2, WDFY4, WDR20, WDR37, WDR41, WDR42A, WDR47, WDTC1, WFDC10B, WFDC11, WFDC12, WFDC13, WFDC3, WFDC5, WFDC6, WFDC9, WIPI-1, WIPI-2, WIPI-3, WIPI-4, WSB2, XKR6, ZFAND2A, ZFYVE1, ZFYVE16, ZFYVE19, ZFYVE21, ZFYVE26, ZFYVE28, ZKSCAN3, ZSWIM1, and ZUFSP.Activator of:
2310045N01Rik, 5430411K18Rik, 9330182L06Rik, AIP4, ASB-7, ATF-6α, Atg4C, BECN1L1, C14orf109, C14orf162, C1orf85, C4orf52, Cdc34, Clathrin LCB, Clm3, CLN1, CLN8, CTBS, Derlin-3, eIF2Bβ, Endophilin B1, Erd2, EVA1B, EVT-2, GP78-1, IQCF3, IRGM, Josephin-1, KIAA0329, KLHL15, LAMP-1, LAMP-2, LAPTM4A, LIX1L, LNX3, LOC392288, LONRF1, MAP LC3α, MARCH5, MLE, MON1A, MTMR5, MTMR8, MVB12A, NBR1, Ndfip1, Parvovirus, Pep12, PHLDA3, PI 3-kinase, PLEKHM1, Rab 24, Rab 26, Rab 7, Rab11-FIP3, Rab4B, Rag D, RNase T2, RNF115, RNF186, SEC23A, SERAC1, Sly1, SNX29, SNX5, SQSTM1-L1, STCH, Strumpellin, TAPT1, TBC1D13, TBC1D3, TFE3, Tlg2, TPPII, TRIM75, TRIP12, tsg 101, Ub-RPS27A, UBE1L, UBE2E3, UBPY, Ubr1, UBXD4, ULK1, USP10, Vam3, VCPIP1, VPS36, VPS51, WDFY1, and WDR91.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Autophagy Inhibitor, 3-MA, 50 mg | sc-205596 | 50 mg | $56.00 | |||
Autophagy Inhibitor, 3-MA, 500 mg | sc-205596A | 500 mg | $256.00 |